Results 71 to 80 of about 157 (83)

Pharmacology of LY315920/S-5920, [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1 H-indol-4-yl]oxy]acetate, a Potent and Selective Secretory Phospholipase A2Inhibitor: A New Class of Anti-Inflammatory Drugs, SPI

Journal of Pharmacology and Experimental Therapeutics, 1999
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2). In a chromogenic isolated enzyme assay, LY315920 inhibited sPLA2 activity with an IC50 of 9 +/- 1 nM or 7.3 x 10(-6) mole fraction, which approached the stiochiometric limit of this assay.
Niles Fox, David W Snyder, Jérôme H Fleisch   +2 more
exaly   +3 more sources

Varespladib (LY315920) effectively reverses experimental neuro-myotoxic effects in a pig model of lethal envenoming by Taipan (O. scutellatus) and Mojave rattlesnake (C. scutulatus)

Toxicon, 2020
L.L. Gilliam, J.N. Gilliam, R.W. Carter, S.P. Samuel, J.M. Gutierrez, D.J. Williams, Y.V. Surovsteva, T. Bulfone, M.R. Lewin   +8 more
openaire   +1 more source

Varespladib (LY315920) appears to be a very potent, broad-spectrum, inhibitor of snake venom PLA2s from six continents

Toxicon, 2016
Matthew R. Lewin, Stephen P. Samue, Janie Merkel, Philip Bickler   +3 more
openaire   +1 more source

Varespladib (LY315920) rescues mice from rapidly lethal doses of venoms from five vipers, suggesting direct and indirect mechanisms for its therapeutic effect in a mouse model of snakebite envenomation

Toxicon, 2019
Matthew R. Lewin, Tommaso Bulfone
openaire   +1 more source

Neutralizing properties of LY315920 toward snake venom group I and II myotoxic phospholipases A2

Toxicon, 2019
José Maria Gutierrez, Julian Fernández, Bruno Lomonte   +2 more
exaly  

Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase A2

Molecules, 2020
Kieran Scott, W Bret Church, Jake Zheng Chen   +2 more
exaly  

Coagulotoxic Cobras: Clinical Implications of Strong Anticoagulant Actions of African Spitting Naja Venoms That Are Not Neutralised by Antivenom but Are by LY315920 (Varespladib)

Toxins, 2018
Bryan Fry, Christina N Zdenek, Bianca Op Den Brouw   +2 more
exaly  

Delayed LY333013 (Oral) and LY315920 (Intravenous) Reverse Severe Neurotoxicity and Rescue Juvenile Pigs from Lethal Doses of Micrurus fulvius (Eastern Coral Snake) Venom

Toxins, 2018
José Maria Gutierrez, Tommaso Bulfone, Lewin Mr   +2 more
exaly  

Indole Inhibitors of Human Nonpancreatic Secretory Phospholipase A2. 3. Indole-3-glyoxamides

Journal of Medicinal Chemistry, 1996
David W Snyder, Noel D Jones, D W Snyder
exaly  

Highly Specific and Broadly Potent Inhibitors of Mammalian Secreted Phospholipases A2

Journal of Medicinal Chemistry, 2008
Michael Gelb, Rob Oslund, Nathan Čermák   +2 more
exaly