From data to discovery: leveraging big data in plant natural products biosynthesis research
The Plant Journal, Volume 122, Issue 6, June 2025.SUMMARY Plant natural products or specialized metabolites play a vital role in drug discovery and development, with many clinically important derivatives such as the anticancer drugs topotecan (derived from the natural alkaloid camptothecin) and etoposide (derived from the natural polyphenol podophyllotoxin).
Matthew McConnachie +4 more
wiley +1 more source
Recent advances in pharmaceutical sciences IV [PDF]
, 2014 Reproducció del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=234Like in the three previous editions, this E-book compiles a series of contributions in the multidisciplinary research arena of Pharmaceutical Sciences. The E-book has been
Estelrich i Latràs, Joan +2 more
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In Memoriam: The Life and Scientific Accomplishments of Frank A. L. Anet (1926–2024)
Journal of Physical Organic Chemistry, Volume 37, Issue 12, December 2024.A memorial review and tribute detailing the life and scientific accomplishments of Frank A. L. Anet, a pioneer of NMR spectroscopy who discovered bedrock principles in organic chemistry and magnetic resonance. ABSTRACT A memorial tribute detailing the life and scientific accomplishments of Frank A. L. Anet, a pioneer of nuclear magnetic resonance (NMR)
Darón I. Freedberg +4 more
wiley +1 more source
Studies on the Synthesis of Phlegmarine-Type Lycopodium Alkaloids: Enantioselective Synthesis of (−)-Cermizine B, (+)-Serratezomine E, and (+)-Luciduline [PDF]
, 2019 The synthesis of the Lycopodium alkaloids, (-)-cermizine B, (+)-serratezomine E, and (+)-luciduline using phenylglycinol-derived tricyclic lactams as chiral scaffolds, is reported.
Amat Tusón, Mercedes +5 more
core +1 more source
The genomic and enzymatic basis for iridoid biosynthesis in cat thyme (Teucrium marum)
The Plant Journal, Volume 118, Issue 5, Page 1589-1602, June 2024.SUMMARY Iridoids are non‐canonical monoterpenoids produced by both insects and plants. An example is the cat‐attracting and insect‐repelling volatile iridoid nepetalactone, produced by Nepeta sp. (catmint) and aphids. Recently, both nepetalactone biosynthetic pathways were elucidated, showing a remarkable convergent evolution. The iridoid, dolichodial,
Samuel J. Smit +8 more
wiley +1 more source
Do airborne biogenic chemicals interact with the PI3K/Akt/mTOR cell signalling pathway to benefit human health and wellbeing in rural and coastal environments? [PDF]
, 2015 Living and taking recreation in rural and coastal environments promote health and wellbeing, although the causal factors involved are unclear. It has been proposed that such environments provide a counter to the stresses of everyday living, leading to ...
Moore, MN
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Total Synthesis of the Myrioneuron Alkaloid (−)‐Schoberine B and Its Enantiomer (+)‐Schoberine B
Advanced Synthesis &Catalysis, Volume 366, Issue 4, Page 948-954, February 20, 2024.Abstract A dynamic kinetic asymmetric transformation, involving the generation of four stereogenic centers with a well‐defined configuration, occurs in the cyclocondensation of diastereomeric mixtures of 2‐oxocyclohexanepropionic acid racemates 6 with (1S,2R)‐cis‐aminoindanol: two major tetracyclic lactams, 7 a and 7 b, that differ in the configuration
Arnau Calbó +3 more
wiley +1 more source
Alkaloids of Lycopodium magellanicum
Phytochemistry, 1979 Abstract Six alkaloids have been isolated from Lycopodium magellanicum. These include the known alkaloids lycopodine, acetyldihydrolycopodine, lycodine, N-methyllycodine, acetylfawcettine and a new alkaloid, 5-dehydro-magellanine. The chemical correlation of magellanine and paniculatine and the establishment of their absolute configuration are ...
Loyola, Luis A. +2 more
openaire +2 more sources
Synthetic approaches towards alkaloids bearing α-tertiary amines [PDF]
, 2016 Alkaloids account for some of the most beautiful and biologically active natural products. Although they are usually classified along biosynthetic criteria, they can also be categorized according to certain structural motifs.
Hager, Anastasia +4 more
core +3 more sources
Ethnomedicinal Use of Pteridophyte from Kolli Hills, Namakkal District, Tamil Nadu, India [PDF]
, 2010 The study enumerates the Pteridophytes widely used by the local people and tribes in the treatment of various diseases in Kolli hills of Namakkal district. They grow in terrestrial, epiphytic and lithophytic habitat.
Perumal, G.
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