Results 151 to 160 of about 2,205 (198)

Lycorine alkaloids from Hymenocallis littoralis

Phytochemistry, 1995
From Hymenocallis littoralis, one new alkaloid, named littoraline, together with 13 known lycorine alkaloids and one lignan, were isolated. The structure and NMR assignments of this new alkaloid were determined by 1D and 2D NMR techniques. Littoraline showed inhibitory activity of HIV reverse transcriptase, and lycorine and haemanthamine showed potent ...
Long-Ze Lin, Hee-Byung Chai, John M Pezzuto   +2 more
exaly   +3 more sources

Synthesis and antiplasmodial activity of lycorine derivatives

Bioorganic and Medicinal Chemistry, 2010
Twenty seven lycorine derivatives were prepared and evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. The best antiplasmodial activities were achieved with lycorine derivatives that present free hydroxyl groups at C-1 and C-2 or esterified as acetates or isobutyrates.
David Gutierrez, Ninoska Flores, Angel G Ravelo   +2 more
exaly   +3 more sources

New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives

Bioorganic and Medicinal Chemistry, 2008
A new lycorine derivative LT1 (4) was isolated from the aerial part and bulbs of Lycoris traubii Hayward (Amaryllidaceae). Its structure including absolute configuration was established by spectroscopic analysis and semi-synthesis to be 1-O-(3'S)-hydroxybutanoyllycorine.
Noriyuki Kogure, Aki Ishiyama, Kazuhiko Otoguro   +2 more
exaly   +3 more sources

Antiinflammatory effects of lycorine and haemanthidine

Phytotherapy Research, 1998
The antiinflammatory effects of lycorine and haemanthidine which were isolated from Sternbergia clusiana (Ker-Gawl.) Ker-Gawl ex Sprengel growing in Turkey were evaluated in mice by the carrageenan-induced oedema test. Antiinflammatory activities of lycorine and haemanthidine were higher than that of indomethacin. © 1998 John Wiley & Sons, Ltd.
G. Çitoğlu, M. Tanker, B. Gümüşel
exaly   +2 more sources

Synthesis and antiviral activity of lycorine derivatives

Journal of Asian Natural Products Research, 2020
There are no effective antiviral drugs to treat hand, foot, and mouth disease. In this study, a series of lycorine derivatives were synthesized and evaluated against enterovirus 71 and coxsackievirus A16 in vitro. Derivatives 7c-m with the phenoxyacyl group at the C-1 position showed higher efficacy and lower toxicity than lycorine.
Ya-Jun, Yang, Jiang-Ning, Liu, Xian-Dao, Pan   +2 more
openaire   +2 more sources

Total Synthesis of (−)-Lycorine and (−)-2-epi-Lycorine by Asymmetric Conjugate Addition Cascade

Organic Letters, 2009
Total syntheses of (-)-lycorine and (-)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C-C bonds and three stereogenic centers in one pot to give synthetically useful chiral cyclohexane derivatives.
Ken-Ichi, Yamada, Mitsuaki, Yamashita, Takaaki, Sumiyoshi, Katsumi, Nishimura, Kiyoshi, Tomioka   +4 more
openaire   +2 more sources

Lycorine: Studies in synthesis

Tetrahedron, 1973
Abstract Several unsuccessful attempts are described at the synthesis of the carbon-nitrogen skeleton of lycorine, utilising 1,2-dihydroisoquinoline intermediates.
S.F. Dyke, M. Sainsbury, J.R. Evans
openaire   +1 more source

Synthesis of the amaryllidaceae alkaloid, lycorine

Journal of the Chemical Society, Chemical Communications, 1975
A key intermediate for the total synthesis of lycorine has been prepared in racemic form; the optically pure form of this epoxylycorinane lactam, obtained from lycorine, has been reconverted into the alkaloid.
Yoshisuke Tsuda, Takehiro Sano, Jun'Ichi Taga, Kimiaki Isobe, Jun Toda, Hiroshi Irie, Hirokazu Tanaka, Sh�z� Takagi, Masae Yamaki, Mayumi Murata   +9 more
openaire   +1 more source

ChemInform Abstract: SYNTHESIS OF LYCORINE‐TYPE ALKALOIDS. II. SYNTHESIS OF D,L‐LYCORINE

Chemischer Informationsdienst, 1978
AbstractDie Darstellung der für die Titelverbindung (XI) bedeutenden Zwischenverbindung (VIIIa) wird verbessert.
O. MOELLER, E.‐M. STEINBERG, K. TORSSELL   +2 more
openaire   +1 more source

Catalytic Asymmetric Assembly of Octahydroindolones: Divergent Synthesis of Lycorine‐type Amaryllidaceae Alkaloids (+)‐α‐Lycorane and (+)‐Lycorine

Chemistry – A European Journal, 2014
AbstractWe report the first catalytic asymmetric approach to octahydroindolones and a divergent enantioselective synthesis of perhydroindole alkaloids, as exemplified by lycorine‐type Amaryllidaceae alkaloids (+)‐α‐lycorane and (+)‐lycorine, from a common intermediate by using a highly concise route.
Zhongwen, Sun, Mingtao, Zhou, Xiang, Li, Xueling, Meng, Fangzhi, Peng, Hongbin, Zhang, Zhihui, Shao   +6 more
openaire   +2 more sources