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The clinical features of Lyme disease have been well documented since its description as a distinct clinical entity in 1975. A better understanding of the diversity of Borrelia strains and species that cause the disease as well as new insights into the immunology and pathogenesis of Lyme disease help explain some of the observed variations in clinical ...
J, Evans, R T, Schoen
+9 more sources
New Insights Into CRASP-Mediated Complement Evasion in the Lyme Disease Enzootic Cycle
Lyme disease (LD), which is caused by genospecies of the Borrelia burgdorferi sensu lato complex, is the most common vector-borne disease in the Northern hemisphere.
Yi-Pin Lin, Peter Kraiczy
exaly +2 more sources
Aberrant T-cell phenotypes in a cohort of patients with post-treatment Lyme disease [PDF]
Post-treatment Lyme Disease (PTLD) is a poorly understood complication of Borrelia burgdorferi infection with significant patient morbidity. Characterized by fatigue, generalized myalgias, and cognitive impairment, PTLD symptomatology closely resembles ...
Alexander A. Girgis +13 more
doaj +2 more sources
When asked to think of headlining diseases, many would choose bubonic plague, smallpox, Ebola, or leprosy. However, Lyme disease makes up for more confirmed diagnostic cases in the United States than all the aforementioned diseases combined.
Beal, Marin Olson
core +5 more sources
The multiplexed single-tier InBios Lyme Detect Multiplex ELISA is more sensitive than standard two-tier tests in the early stages of Lyme disease [PDF]
There are nearly 500,000 cases of Lyme disease each year in the United States; 10%–20% of them result in the development of a debilitating chronic disease known as post-treatment Lyme disease.
Anna F. Hickman +3 more
doaj +2 more sources
Lyme Disease Biobank: 10 years of 3 month follow-up visits from 2014 to 2023 [PDF]
IntroductionLyme Disease Biobank (LDB) enrolls participants with signs and symptoms of early Lyme disease (LD) from endemic areas and makes samples available to researchers developing more accurate diagnostics. From 2014 to 23, 466 cases and 367 controls
Elizabeth J. Horn +7 more
doaj +2 more sources
Genomic insights into the Ixodes scapularis tick vector of Lyme disease
Ticks transmit more pathogens to humans and animals than any other arthropod. We describe the 2.1 Gbp nuclear genome of the tick, Ixodes scapularis (Say), which vectors pathogens that cause Lyme disease, human granulocytic anaplasmosis, babesiosis and ...
Jason M Meyer +2 more
exaly +2 more sources
What is the real number of Lyme disease cases in Canada?
Background Lyme disease is emerging in Canada due to expansion of the range of the tick vector Ixodes scapularis from the United States. National surveillance for human Lyme disease cases began in Canada in 2009.
N. H. Ogden +12 more
doaj +2 more sources
Within the last decade, Lyme borreliosis has emerged as a complex new infection whose distribution is worldwide. The disorder is caused by a recently recognized spirochete, B. burgdorferi, transmitted by ticks of the I. ricinus complex. Certain species of mice are critical in the life cycle of the spirochete, and deer appear to be crucial to the tick ...
N, Hamlet, D, Nathwani
+15 more sources
We now have more than 30 years of solid, scientific research about Lyme disease, a relatively common, vector-borne illness in parts of the United States and of Europe. Although there is still widespread misunderstanding of and misinformation about the disease among the lay public, its clinical manifestations as well as how to diagnose and to treat it ...
Dale R, Hamilton, John W, Bachman
openaire +9 more sources

