Results 181 to 190 of about 816,960 (351)

Single‐Nucleus Multi‐Omics Reveals Hypoxia‐Driven Angiogenic Programs and Their Epigenetic Control in Sinonasal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Single‐nucleus multi‐omics profiling of sinonasal squamous cell carcinoma unveils a hypoxia‐driven angiogenic axis. A specific hypoxic tumor subpopulation orchestrates endothelial tip cell differentiation via epigenetically regulated ADM and VEGFA secretion.
Chaelin You, Jaewoo Park, Jung Yeon Jang, Junho Noh, Jaehyun Lee, Geunho Kwon, Myeong Sang Yu, Yoo‐Sam Chung, Seung‐Jun Lee, Keunsoo Kang, Jihwan Park, Ji Heui Kim, Kyuho Kang   +12 more
wiley   +1 more source

Clinicopathologic Determinants of Lymph Node Count and Prognostic Significance of Metastatic Lymph Node Ratio in Colorectal Cancer. [PDF]

Diagnostics (Basel)
Yildirim F, Sezak M, Bozbiyik O, Gursoy P, Doganavsargil B.   +4 more
europepmc   +1 more source

Online Adaptive MRI-Guided Radiotherapy for Primary Tumor and Lymph Node Boosting in Rectal Cancer

, 2023
Chavelli M. Kensen, A. Betgen, Lisa Wiersema, Femke P. Peters, Mutamba T. Kayembe, Corrie A.M. Marijnen, Uulke A. van der Heide, Tomas Janssen   +7 more
openalex   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Cadaveric evidence on lymph node counts and grossing accuracy in pelvic lymph node dissection for prostate cancer staging. [PDF]

Sci Rep
Tunksakul P, Piyaman P, Woranisarakul V, Wanvimolkul N, Sovikul K, Mahamongkol K, Ratanayotha A.   +6 more
europepmc   +1 more source

Foundation Model‐Enabled Multimodal Deep Learning for Prognostic Prediction in Colorectal Cancer with Incomplete Modalities: A Multi‐Institutional Retrospective Study

Advanced Science, EarlyView.
FLARE, a multimodal AI framework, combines pathology slides, radiology scans, and clinical reports to predict colorectal cancer outcomes, even when some tests are missing. Evaluated retrospectively in 1679 patients from four medical centers, it consistently achieved the best prognostic accuracy and clearly separated high‐ and low‐risk groups.
Linhao Qu, Chengsheng Zhang, Yingyong Hou, Feng Tang, Weiqi Sheng, Dan Huang, Zhijian Song   +6 more
wiley   +1 more source

Prognostic significance of lymph node yield in pelvic lymph node dissection for bladder cancer: population-based study. [PDF]

World J Surg Oncol
He W, Wang Z, Wang M, Chen Q, Zhang C, Wang Y, Yu X, Wang Y, Zhang H, Xie J, Yang X, Zhang Z, Xu C, Zeng S.   +13 more
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

Lymph node with central hypodensity. [PDF]

J Bras Pneumol
Marchiori E, Hochhegger B, Zanetti G.
europepmc   +1 more source

Actinin-4 increases cell motility and promotes lymph node metastasis of colorectal cancer [PDF]

, 2005
Kazufumi Honda, Tesshi Yamada, Yasuharu Hayashida, Masashi Idogawa, Satoshi Sato, Fumio Hasegawa, Yoshinori Ino, Masaya Ono, Setsuo Hirohashi   +8 more
openalex   +1 more source