Results 201 to 210 of about 1,831,806 (317)

The Nuclear Receptor NR1B1/RARα Arrests the Differentiation of Anti‐Tumor Effector Cytotoxic T Cells

open access: yesAdvanced Science, EarlyView.
RARα is highly expressed by differentiated effector and exhausted T cells and exerts a negative effect on effector T cell differentiation and the associated trafficking receptor switch. Upregulated RARα levels decrease the nuclear histone acetylase (HAT) activity, and this suppresses the expression of key Teff transcription factor BATF and trafficking ...
Patrick Niekamp   +5 more
wiley   +1 more source

Defining Optimal Lymph Node Yield in Gastrectomy: A Real-World Cohort Analysis. [PDF]

open access: yesWorld J Surg Oncol
Li R   +6 more
europepmc   +1 more source

Delivery of A Chemically Modified Noncoding RNA Domain Improves Dystrophic Myotube Function

open access: yesAdvanced Science, EarlyView.
CYTOR is a pro‐myogenic ncRNA in skeletal muscle. Here, chemical probing of CYTOR, coupled with functional cellular assays identifies exon 2 as an independent myogenic RNA domain. Chemical engineering of CYTOR exon 2 RNA improves pharmacologic properties, including RNA stability and cell‐autonomous immunogenicity.
Zeinabou Niasse‐Sy   +6 more
wiley   +1 more source

Risk factors for cervical lymph node metastasis in oropharyngeal cancer and its impact on prognosis

open access: yesBrazilian Journal of Otorhinolaryngology
Objective: To understand the characteristics of cervical lymph node metastasis in Oropharyngeal Squamous Cell Carcinoma (OPSCC) patients, explore the risk factors for lymph node metastasis, and its impact on prognosis. Methods: Retrospective cohort study.
Li Zhang   +4 more
doaj  

TRAF3IP3 Induces ER Stress‐Mediated Apoptosis with Protective Autophagy to Inhibit Lung Adenocarcinoma Proliferation

open access: yesAdvanced Science, EarlyView.
Schematic diagram of the working model of TRAF3IP3 in the coordination of ER stress and autophagy related apoptosis in lung cancer cells. Abstract TNF receptor‐associated factor 3 interacting protein 3 (TRAF3IP3/T3JAM) exhibits dual roles in cancer progression. While upregulated in most malignancies and critical for immune regulation.
Guang Zhao   +11 more
wiley   +1 more source

An ensemble learning model to predict lymph node metastasis in early gastric cancer. [PDF]

open access: yesSci Rep
Song K   +7 more
europepmc   +1 more source

CK2B Induces CD8+ T‐Cell Exhaustion through HDAC8‐Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti‐PD‐1 Therapy in Non‐Small‐Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
αPD‐1 therapy has left an indelible mark in the field of NSCLC treatment; however, its efficacy is limited in clinical practice owing to the effector T‐cell exhaustion. These findings underscore CK2B as a promising target for overcoming the exhaustion of effector CD8+ T cells, thereby enhancing the efficacy of αPD‐1 and adoptive cell therapies in NSCLC.
Shaochuan Liu   +15 more
wiley   +1 more source

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