Results 51 to 60 of about 714,938 (290)

CD9+ B Cells Induce T Follicular Helper Cell Apoptosis to Regulate Germinal Center Regression

Advanced Science, EarlyView.
A unique subset of CD9+ B cells regulates germinal center B (GC‐B) cell regression by inducing T follicular helper (Tfh) cell apoptosis through multiple signaling pathways, such as ALCAM‐CD6. FOXP1 plays a key role in GC‐B cell differentiation. These findings clarify mechanisms of GC degeneration and termination and offer potential targets for adenoid ...
Wenjing Liao, Lijuan Song, Meiqian Xu, Tianhao Liang, Yixuan Chen, Gui Chen, Zaihuan Lin, Huakang Du, Guofei Feng, Zhiming Feng, Qi Zhang, Fan Pan, Saixuan Yang, Xinyin Zhang, Wenxu Peng, Tianlong Li, Zhuoshen Lin, Yabang Chen, Jiayi Liu, Baoxin Peng, Yan Liu, Xing Niu, Ting Li, Chengyu Huang, Ke Mo, Jianlei Xie, Yu Zou, Xiaowen Zhang   +27 more
wiley   +1 more source

Does shear wave ultrasound independently predict axillary lymph node metastasis in women with invasive breast cancer? [PDF]

, 2013
Shear wave elastography (SWE) shows promise as an adjunct to greyscale ultrasound examination in assessing breast masses. In breast cancer, higher lesion stiffness on SWE has been shown to be associated with features of poor prognosis.
Thomson, Kim, Petra Rauchhaus, Patsy Whelehan, Rauchhaus, Petra, Andrew Evans, Vinnicombe, Sarah, Michie, Caroline O, Caroline O. Michie, Kim Thomson, Purdie, Colin A, Whelehan, Patsy; id_orcid, Alastair Thompson, Jordan, Lee B., Sarah Vinnicombe, Lee B. Jordan, Evans, Andrew, Thompson, Alastair, Colin A. Purdie   +17 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

The Outcome of Patients with Melanoma Is Not Associated with the Time Point of Lymphatic Mapping with Respect to Excisional Biopsy of the Primary Tumor [PDF]

, 2010
Background: Sentinel lymph node biopsy (SLNB) has become the standard care for melanoma and is an important diagnostic procedure. It has been doubted whether lymphoscintigraphy detects the correct sentinel lymph node (SLN) when excision of the tumor and ...
Ruzicka, T., Berking, Carola, Geimer, Till, Geimer, T., Kunte, C., Berking, C., Baumert, Jens, Schmid-Wendtner, Monika-Hildegard, Gauwerky, Katharina J., Kunte, Christian, Flaig, Michael J., Gauwerky, K.J., Baumert, J.J., Flaig, M.J., Ruzicka, Thomas, Schmid-Wendtner, M.H.   +15 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Research Progress of Lobe-specific Lymphadenectomy on early stage Lung Cancer Operation

Chinese Journal of Lung Cancer, 2011
Systematic nodes dissection be the standard procedure for lung cancer during operation. While Surgery for early lung cancer lymph node removal method has been controversial, particularly for clinical early stage non-small cell lung cancer that has ...
Jian CHEN, Yang SHEN-TU
doaj  

A multicenter prospective study to determine the optimal range of lymph node dissection in pancreatic cancer surgery after neoadjuvant chemotherapy (LYMRIN-Trial): Project study by the Japan Pancreas Society and JON 2302-P.

PLoS ONE
IntroductionClear evidence regarding the optimal extent of lymph node dissection during pancreatectomy for pancreatic ductal adenocarcinoma (PDAC) is lacking.
Nana Kimura, Yoshihiro Shirai, Ayaka Itoh, Katsuhisa Hirano, Kazuto Shibuya, Kenta Murotani, Makoto Ueno, Sohei Satoi, Hiroaki Nagano, Junji Furuse, Yoshifumi Takeyama, Tsutomu Fujii, LYMRIN-Trial collaborators   +12 more
doaj   +1 more source

Sentinel Lymph Node Biopsy and Complete Lymph Node Dissection for Melanoma [PDF]

Current Oncology Reports, 2019
The main surgical treatment for invasive malignant melanoma consists of wide surgical and examination of the sentinel node and in selected cases complete lymph node dissection. The aim of this review is to present data for the optimal surgical management of patients with malignant melanoma.A surgical excision margin of 1-2 cm is recommended for ...
Falk Delgado, Alberto, Zommorodi, Sayid, Delgado, Anna Falk   +2 more
openaire   +3 more sources

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Long-term results of treatment of right-sided colon cancer with mesocolic excision and D3-lymph node dissection

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2014
Aim of investigation. To estimate efficacy of D3-lymph node dissection with mesocolic excision in comparison to standard surgical technique of right hemicolectomy for right colon cancer in long-term terms.Methods.
S. K. Efetov, I. A. Tulina, A. Yu. Kravchenko, D. N. Fedorov, S. V. Efetov, P. V. Tsarkov   +5 more
doaj