Results 111 to 120 of about 278,243 (313)

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

Rad51 expression is associated with lymph node metastasis.

, 2017
Strong Rad51 immunoreactivity was detected in a tumor with lymph node metastasis (A), but not in a tumor with negative lymph node metastasis (B). Corresponding H&E staining of a metastatic lymph node (C) and a negative lymph node (D).
Dian-ying Liao (3666862), Wei-ya Wang (2855069), Li Xie (108913), Yan Li (23143), Feng Luo (47640), Feng Xu (89016), Jin Wang (29560), Jiang-hong Xiao (3666865)   +7 more
core   +1 more source

Lighting up Macrophage Reprogramming Assists Immunosuppressive Niche Modulation in Primary Tumors and Tumor‐Draining Lymph Nodes of Breast Cancer

Advanced Science, EarlyView.
This study develops an intelligent NIR‐II‐responsive nanoplatform to combat immunosuppression in breast cancer. It enables real‐time visualization of macrophage activity via “off‐on” fluorescence while simultaneously reprogramming macrophages through the CSF‐1R and CD47‐SIRPα pathways.
Yingbo Li, Di Chang, Jie Yang, Ying Bai, Min Chen, Daoshuang Li, Zuoyu Xu, Jiaxin Yuan, Xiaoxuan Xu, Zhiqi Zhang, Yize Li, Zixin Chen, Jinbing Xie, Zebin Xiao, Shenghong Ju   +14 more
wiley   +1 more source

Association of LVDpodoplanin, LVDVEGFR3 and HEVD with lymph node metastasis.

, 2015
N.A., not applicable; SLN, sentinel lymph node; LVD, lumphatic vessel density; HEVD, high endothelial venule density; SD, standard deviation. The subsets of SLN in relation to LVDs and HEVDwere analyzed using Mann-Whitney U-test.
Tomokazu Yoshizaki (407160), Naohiro Wakisaka (407153), Seiichi Yoshimoto (833098), Kazuhira Endo (407155), Yasuhisa Hasegawa (691533), Akihiro Shiotani (682360), Makiko Moriyama-Kita (833101), Junkichi Yokoyama (833100), Masashi Sugasawa (768211), Kouki Miura (833099)   +9 more
core   +1 more source

Amplification of Endoplasmic Reticulum Stress via Inhibiting Lipid Droplet Formation to Enhance Chemodynamic Immunotherapy

Advanced Science, EarlyView.
An endoplasmic reticulum (ER)‐targeted chemodynamic nanoagent (TCBQ/iLD‐ER NPs) comprising •OH‐generating tetrachloro‐1,4‐benzoquinone (TCBQ) and lipid droplets (LDs) formation inhibitor (iLD) is developed for chemodynamic immunotherapy of tumors. After ingestion by cancer cells, TCBQ/iLD‐ER NPs preferentially accumulate in the ER and react with ER ...
Huilan Cai, Shaoru Zhuang, Yang Zhu, Rujiang Ao, Meili Yu, Tingting Cui, Jun Wang, Xuegang Niu, Hongwei Huang, Shanshan Peng, Yu He, Lisen Lin, Huanghao Yang   +12 more
wiley   +1 more source

[Hidradenocarcinoma of the Scrotum with Lymph Node Metastasis].

Acta medica portuguesa, 2018
Hidradenocarcinoma is a rare neoplasm of the eccrine cells of the sweat glands, usually asymptomatic with slow growing and higher incidence between 50 and 80 years, occurring in both sexes and preferentially located in the palmar, plantar, frontal, axillary and nuchal regions.
Maria Inês Simões, Isabel Marcão, Mário Toscano, Luís Borges   +3 more
openaire   +2 more sources

Model of lymph node metastasis posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma

, 2018
Yi Luo,1 Xiao-Cheng Xu,2 Jie Shen,3 Jing-Jing Shi,4 Si Lu,5 Wei He,6 Jian-Yong Lei,7 Ding-Cun Luo4 1West China School of Medicine, Sichuan University, Chengdu, China; 2Department of Surgery of Thyroid and Breast, Wujiang District of Suzhou First People ...
Shi JJ, Lei JY, Xu XC, Shen J, He W, Lu S, Luo Y, Luo DC   +7 more
core  

Triple‐Negative Breast Cancer Cells Utilize IL8 and CXCL1 to Suppress NK Cells’ Function and Facilitate Cancer Metastasis

Advanced Science, EarlyView.
Triple‐negative breast cancer (TNBC) cells evade natural killer (NK) cell immunity by secreting IL8 and CXCL1. These chemokines suppress NK cells’ function via CXCR1/2 and enhance cancer cells’ survival through PD‐L1 upregulation and BCL‐2 anti‐apoptotic signaling.
Mingheng Yuan, Hongmei Yang, Renfei Wu, Meng Hao, Xiangpeng Chu, Chuxia Deng, Kathy Qian Luo   +6 more
wiley   +1 more source

Sentinel lymph node concept in gastric cancer with solitary lymph node metastasis

World Journal of Gastroenterology, 2004
To study the localization of the solitary metastases in relation to the primary gastric cancers and the feasibility of sentinel lymph node (SLN) concept in gastric cancer.Eighty-six patients with gastric cancer, who had only one lymph node involved, were regarded retrospectively as patients with a possible sentinel node metastasis, and the distribution
Li-Yang, Cheng, Shi-Zhen, Zhong, Zong-Hai, Huang   +2 more
openaire   +2 more sources

Significance of lymph node metastasis in pancreatic neuroendocrine tumors.

, 2016
210 Background: Pancreatic neuroendocrine tumor (PNET) is uncommon, and its prognosis is generally better than that of pancreatic cancer. Although some PNET patients have lymph node metastasis, its effect on their prognosis is unclear, lymph node ...
Toru Beppu, Hideo Baba, Nobuyuki Ozaki, Kota Arima, Takaaki Higashi, Akira Chikamoto, Kensuke Yamamura, Risa Inoue, Takayoshi Kaida, Shinjiro Tomiyasu, Yuuki Kitano, Katsunori Imai, Hiroshi Takamori, Katsunobu Taki, Masahiko Hirota, Daisuke Hashimoto   +15 more
core   +1 more source