Results 41 to 50 of about 1,001,115 (258)

Performance of parametrial ultrastaging in predicting pelvic lymph node metastasis.

, 2022
Performance of parametrial ultrastaging in predicting pelvic lymph node ...
Nicolò Bizzarri
core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

DeepLNM: A Multimodal Model for Predicting Lymph Node Metastasis in Colorectal Cancer [PDF]

Advanced science
Traditional diagnosis may miss positive LNM cases, and pathologists face a workload; therefore, we develop DeepLNM, a multimodal model that predicts lymph node metastasis in colorectal cancer from H&E WSIs, CT images, and text. DeepLNM is robust across internal, external, and prospective cohorts and, in a user study, improves diagnostic accuracy while ...
Zhang Z, Lu C, Wang Z, Cen Z, Zhou Y, Li D, Xie Q, Li B, Guo S, Gan Z, Zhu E, Li J, Aimaier A, Mao R, Qiu W, Zhao C, Tan Y, Liu X, Ma H, Geng T, Wu P, Du H, Wang Y, Liu Y, Liang L.   +24 more
europepmc   +2 more sources

Process of distant lymph node metastasis in colorectal carcinoma: Implication of extracapsular invasion of lymph node metastasis [PDF]

BMC Cancer, 2011
We previously demonstrated that extracapsular invasion (ECI) at a metastatic sentinel node was significantly associated with the presence of positive non-sentinel nodes in patients with breast cancer. However, the mechanism of metastatic spreading of tumor cells to distant lymph nodes in patients with colorectal carcinoma is not fully understood.
Asao Takayuki, Tsutsumi Soichi, Yamaguchi Satoru, Yajima Reina, Tabe Yuichi, Fujii Takaaki, Kuwano Hiroyuki   +6 more
openaire   +3 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Risk factors for lymph node metastasis among micro-PTC subgroups.

, 2023
Risk factors for lymph node metastasis among micro-PTC subgroups.
Hye Won Lim (17457989), Jin Ho Lee (513073), Ji Sung Yoon (5683793), Kyu Chang Won (5683796), Hyoung Woo Lee (5683799), Sa Rang Kwon (17457986), Yong Uk Jeong (17457992), Woo Jin Song (17457980), In Chan Um (17457983), Seung Min Chung (5683787), Jun Sung Moon (5683790)   +10 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Comparison of metabolites obtained by ¹H-NMR spectroscopy between patient groups classified by the presence of lymph node metastasis and lateral lymph node metastasis.

, 2018
Comparison of metabolites obtained by 1H-NMR spectroscopy between patient groups classified by the presence of lymph node metastasis and lateral lymph node metastasis.
Jandee Lee (4915675), Hyeon-Man Baek (294156), Jin Young Kwak (386335), Kyunghwa Han (622827), Eun-Kyung Kim (201590), Ji Won Seo (4915672), Hee Jung Moon (294161), Jung Hyun Yoon (382148), Vivian Youngjean Park (3146970)   +8 more
core   +1 more source