Results 151 to 160 of about 498,192 (310)

Trapping of Calibrated Microspheres in Rat Lymph Nodes

, 2017
The diagnostic and therapeutic usefulness of intralymphatic microspheres depends on the site and duration of lodgement of the injected particles within the lymph nodes.The size of the spheres is probably the most important factor that determines whereand
Ludwig, J
core  

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

GENERALIZED LIPOMATOSIS OF LYMPH NODES: A LYMPHOGRAPHIC PROBLEM IN DIFFERENTIATING FROM MALIGNANCY

, 2017
Lymphography in a 50-year-old male patient showed suspicious lymph nodes in the para-aortal region.Exploratory laparotomy and histological examination  of  biopsied  material gave no evidence of  tumor or lymphoma.
Manzke, E, Pflieger, H, Kurrle, E, Heymer, B   +3 more
core  

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

LYMPH DRAINAGE ORIGINATING FROM THE LOWER ESOPHAGUS AND GASTRIC CARDIA AS MEASURED BY RADIOISOTOPE UPTAKE IN THE REGIONAL LYMPH NODES FOLLOWING LYMPHOSCINTIGRAPHY

, 2017
Lymph drainage originating from the lower esophagus and gastric cardia was determined using uptake of radioisotope (RI) in the regional lymph nodes in 19 patients with primary cancer at these sites.
Shimazu, H, Aikou, T, Baba, M, Natugoe, S, Tenabe, G   +4 more
core  

A Hydrogen‐Releasing Nanozyme Engineers a Mitochondrial ROS Amplifier for Self‐Sustaining Catalytic Immunotherapy

Advanced Science, EarlyView.
We developed a RhPd‐H nanozyme that integrates enhanced POD‐mimetic catalytic activity with thermally triggered H2 release. H2 shields and reprograms mitochondria to continuously leak endogenous ·O2−. This dual‐path ROS spatially and temporally disrupts redox homeostasis, inducing persistent oxidative stress for tumor suppression and antitumor immunity,
Mingfan Shi, Jingrui Cao, Tong Wu, Guang Yang, YaWen Yang, Shixin Zhang, Wenwen Su, Hongyu Chu, Yangyang Zhao, Shan Jiang, Qiong Wu, Dongxu Jiao, Fangfang Chen   +12 more
wiley   +1 more source

RED BLOOD CELL CATABOLISM IN LYMPH NODES OF THE SHEEP AND RAT: QUANTITATION

, 2017
Estimates have been made of the number of red blood cells catabolised in the lymph nodes of the sheep and the rat. These estimates were based on observations on the output of bilirubin in intestinal lymph of the sheep and on bilirubin output in thoracic ...
Shannon, AD, Quin, JW
core  

When Lymph Nodes Don't Lie: Report of Three Unusual Presentations of Thoracic Tumors. [PDF]

Diagnostics (Basel)
Lucà S, Barbato F, Di Maio A, Montella L, Farese S, Di Guida G, Leonardi B, Giannatiempo R, Salvi R, Montella M, Della Corte CM, Fasano M, Orditura M, Fiorelli A, Morgillo F, Franco R.   +15 more
europepmc   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source