Results 141 to 150 of about 43,762 (300)

Differential receptor binding and regulatory mechanisms for the lymphangiogenic growth factors VEGF-C and VEGF-D [PDF]

, 2016
VEGF-C and VEGF-D are secreted glycoproteins that induce angiogenesis and lymphangiogenesis in cancer, thereby promoting tumor growth and spread. They exhibit structural homology and activate VEGFR-2 and VEGFR-3, receptors on endothelial cells that ...
Achen, Marc G, Davydova, Natalia, Harris, Nicole C, Ishaq, Musarat, Karnezis, Tara, Paquet-Fifield, Sophie, Roufail, Sally, Stacker, Steven A, Streltsov, Victor A, Williams, Steven P   +9 more
core   +1 more source

Lymph Node‐Targeted Nanomaterials for Controlled Nano‐Immunotherapy

Small Structures, Volume 7, Issue 1, January 2026.
This study primarily investigates lymph node‐targeted immunotherapeutic strategies, focusing on the mechanisms of immune response regulation within lymph nodes. By targeting distinct immune signaling pathways, we systematically explore the development of nanodrug delivery systems specifically designed for lymph node targeting to achieve enhanced ...
Yitong Zhao, Mengjun Wang, Ming Ma, Yu Zhang, Haoan Wu   +4 more
wiley   +1 more source

Increased mROS Generation Associates With Cardiovascular Risk in BioHEART‐CT PBMCs

Clinical and Translational Science, Volume 19, Issue 1, January 2026.
ABSTRACT Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide, and identifying accessible blood‐based biomarkers is therefore a clinical priority. Given the involvement of oxidative stress and immune cell dysfunction in atherosclerosis, we investigated whether mitochondrial reactive oxygen species (mROS) production
W. Eugene Lee, Albert Henry, Eleanor Ruth Spenceley, Eszter Sagi‐Zsigmond, Blake Bowen, Tung V. Nguyen, Michael P. Gray, Stuart M. Grieve, Joseph E. Powell, Gemma A. Figtree   +9 more
wiley   +1 more source

Foxp3 is correlated with VEGF-C expression and lymphangiogenesis in cervical cancer

World Journal of Surgical Oncology, 2017
Background Recent observations revealed Foxp3 participated in the development of cervical cancer. Furthermore, Foxp3 has a vital function in the lymphatic metastasis of cervical cancer.
Jiabu Tang, Zheng Yang, Zhuo Wang, Zhen Li, Hongmei Li, Jinbao Yin, Min Deng, Wei Zhu, Chao Zeng   +8 more
doaj   +1 more source

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

, 2011
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff, Abtahian, Alice Y. Pollitt, Aparicio-Vergara, Bertozzi, Bohmer, Brenda A. Finney, Caetano Reis e Sousa, Carramolino, Caton, Cecile Bénézech, Chagraoui, Cheng, Christou, Clausen, Colonna, Craig E. Hughes, Cueni, de Boer, Diego Mourao-Sa, Edina Schweighoffer, Francesca Barone, Gerard B. Nash, Gustafsson, Hodivala-Dilke, Hughes, Hughes, Humphreys, Ichise, Kate L. Lowe, Kaufmann, Kerrigan, Leyre Navarro-Núñez, Makinen, Martin-Villar, May, Mocsai, Mourao-Sa, Navarro, Navarro, Nicholas Smithers, Nieswandt, Pardridge, Ramirez, Saijo, Schacht, Sebzda, Spalton, Stacey A. Langan, Steve P. Watson, Steve Sheardown, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Tammela, Tang, Tiedt, Tober, Turner, Uhrin, Victor L. J. Tybulewicz, Warburton, Watson, Williams, Xie, Xu   +66 more
core   +2 more sources

Lymphedema and Therapeutic Lymphangiogenesis

BioMed Research International, 2013
Lymphedema is a disorder of the lymphatic vascular system characterized by impaired lymphatic return and swelling of the extremities. Lymphedema is divided into primary and secondary forms based on the underlying etiology. Despite substantial advances in both surgical and conservative techniques, therapeutic options for the management of lymphedema are
Yukihiro Saito, Hironori Nakagami, Yasufumi Kaneda, Ryuichi Morishita   +3 more
openaire   +2 more sources

Current Status of Research on Losartan in Tumour Therapy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Losartan, a widely prescribed antihypertensive agent, has attracted growing interest as a potential adjuvant in cancer therapy due to its affordability, established safety profile and pleiotropic effects. Emerging preclinical evidence demonstrates that losartan can effectively modulate the tumour microenvironment (TME) by inhibiting ...
Han Wang, Shuang Yuan, Hongjing Wang
wiley   +1 more source

Non-coding RNAs as Regulators of Lymphangiogenesis in Lymphatic Development, Inflammation, and Cancer Metastasis

Frontiers in Oncology, 2019
Non-coding RNAs (ncRNAs), which do not encode proteins, have pivotal roles in manipulating gene expression in development, physiology, and pathology. Emerging data have shown that ncRNAs can regulate lymphangiogenesis, which refers to lymphatics deriving
Ming-xin Cao, Ya-ling Tang, Wei-long Zhang, Ya-Jie Tang, Ya-Jie Tang, Xin-hua Liang   +5 more
doaj   +1 more source

Recent advances in hypertension and cardiovascular toxicities with vascular endothelial growth factor inhibition [PDF]

, 2017
No abstract ...
Danser, A.H. Jan, Herrmann, Joerg, Lang, Ninian N., Touyz, Rhian M., van den Meiracker, Anton H.   +4 more
core   +1 more source

Lymphangioblasts in Embryonic Lymphangiogenesis

Lymphatic Research and Biology, 2003
The origin of the lymphatic endothelium, either from the venous system or mesenchymal lymphangioblasts, presents as a persistent controversy. Recently, highly specific markers of the lymphatic endothelium have been found, enabling us to reinvestigate the embryonic origin of the lymphatics.The homeobox transcription factor, Prox1, is expressed in ...
Wilting, Jörg, Tomarev, Stanislav I., Christ, Bodo, Schweigerer, Lothar   +3 more
openaire   +3 more sources