Results 11 to 20 of about 11,099 (227)

GPNMB immunohistochemistry is a useful ancillary tool for the diagnosis of pulmonary lymphangioleiomyomatosis. [PDF]

Histopathology
We evaluated the diagnostic utility of GPNMB immunohistochemistry in LAM. GPNMB showed strong expression in LAM cells, while the differential diagnostic mimics showed no or only low expression. Based on its 100% sensitivity and specificity in our cohort, GPNMB is a highly reliable immunohistochemical marker for the diagnosis of LAM.
Szalai F, Pápay J, Dezső K, Kuthi L, Sebestyén A, Khoór A, Krencz I.   +6 more
europepmc   +2 more sources

Recurrent Pneumothorax Revealing Lymphangioleiomyomatosis in a Young Woman: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Lymphangioleiomyomatosis (LAM) should be considered in young women presenting with recurrent pneumothorax. Early diagnosis through high‐resolution computed tomography(HRCT)and histopathological analysis is essential for timely management and improved patient outcomes.
Zhang Q, Zuo T, He Y, Zheng W.
europepmc   +2 more sources

Renal Angiomyolipoma in a Young Woman With Tuberous Sclerosis: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Tuberous sclerosis is a rare autosomal dominant genetic disorder caused by mutations in tumor suppressor genes (TSC1/2), leading to hamartomas in multiple organs. Renal angiomyolipomas are often asymptomatic but can cause mass effects or bleeding if they enlarge, requiring treatment.
Lema DD, Ngowi BN, Lekei E, Sengelela D, Kasyupa F, Pyuza J, Mucunguzi D, Mremi A.   +7 more
europepmc   +2 more sources

Lymphangioleiomyomatosis [PDF]

Seminars in Respiratory and Critical Care Medicine, 2020
AbstractLymphangioleiomyomatosis (LAM) is a slow albeit progressive rare neoplastic disease featured with diffuse thin-walled cysts in lungs and angiomyolipomas in kidneys. LAM affects almost exclusively women and has one of the strongest gender predispositions of any extragenital human disease. Two forms of LAM present clinically, sporadic (S-LAM) and
Kai-Feng, Xu, Wenshuai, Xu, Song, Liu, Jane, Yu, Xinlun, Tian, Yanli, Yang, Shao-Ting, Wang, Weihong, Zhang, Ruie, Feng, Tengyue, Zhang   +9 more
  +6 more sources

Lymphangioleiomyomatosis [PDF]

Klinicka Onkologie, 2019
Lymphangioleiomyomatosis (LAM) is a rare systemic disease that occurs sporadically (S/LAM) or as part of tuberous sclerosis (TS/LAM). LAM is characterized by proliferation of abnormal smooth muscle cells. This disease clinically manifests as dyspnea on exertion and pneumothorax.
Martina, Doubková, Marianna, Štefániková, Vladimír, Čan, Zdeněk, Merta, Marek, Svoboda   +4 more
openaire   +3 more sources

A Clinical Case of Pulmonary Lymphangioleiomyomatosis

Туберкулез и болезни лёгких, 2022
The article describes a clinical case of pulmonary lymphangioleiomyomatosis (LAM) in a 44-year-old female Patient N., who has been suffering from this disease for a long time.
S. S. Kazakova, E. V. Аftaeva, Z. V. Zinovieva   +2 more
doaj   +1 more source

Effectiveness of pulmonary rehabilitation in lymphangioleiomyomatosis

Indian Journal of Respiratory Care, 2021
Lymphangioleiomyomatosis (LAM) is a cystic lung disease frequently associated with reduced exercise capacity, mostly affecting young women. The disease is characterized by progressive pulmonary cystic change, recurrent pneumothorax, chylous pleural ...
Manivel Arumugam, Senthil Dhanasekaran, Kancherla Roopa, Pitchaimani Govindharaj   +3 more
doaj   +1 more source

Lymphangioleiomyomatosis and Langerhans cell histiocytosis - two case reports from our practice [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2022
Introduction. Lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis are the most common pulmonary cystic diseases. Although they differ in pathogenesis, they share several features.
Milenković Ana, Ilić Miroslav, Javorac Jovan, Savić Nevena, Lalić Nensi   +4 more
doaj   +1 more source

Microscopic precursor lesions of uterine lymphangioleiomyomatosis associated with incidental nodal lymphangioleiomyomatosis: A case report and discussion of pathogenesis

Human Pathology: Case Reports, 2020
A 47 yo woman underwent resection of an endometrial adenocarcinoma with pelvic lymph node biopsies. She was found to have incidental nodal lymphangioleiomyomatosis (LAM).
Charles M. Lombard
doaj   +1 more source

Tissue‐Engineered Disease Modeling of Lymphangioleiomyomatosis Exposes a Therapeutic Vulnerability to HDAC Inhibition

Advanced Science, 2023
Lymphangioleiomyomatosis (LAM) is a rare disease involving cystic lung destruction by invasive LAM cells. These cells harbor loss‐of‐function mutations in TSC2, conferring hyperactive mTORC1 signaling. Here, tissue engineering tools are employed to model
Adam Pietrobon, Julien Yockell‐Lelièvre, Nicole Melong, Laura J. Smith, Sean P. Delaney, Nadine Azzam, Chang Xue, Nishanth Merwin, Eric Lian, Alberto Camacho‐Magallanes, Carole Doré, Gabriel Musso, Lisa M. Julian, Arnold S. Kristof, Roger Y. Tam, Jason N. Berman, Molly S. Shoichet, William L. Stanford   +17 more
doaj   +1 more source