Results 221 to 230 of about 9,431,933 (366)
The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication
Advanced Science, EarlyView.Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li +9 more
wiley +1 more source
Trimethylamine-N-oxide damages astrocytes and lymphatic endothelial cells in the cerebral lymphatic system. [PDF]
IBRO Neurosci RepSu ML +8 more
europepmc +1 more source
Advanced Science, EarlyView.Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li +24 more
wiley +1 more source
Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders. [PDF]
Plast Reconstr Surg Glob OpenWatson JA +12 more
europepmc +1 more source
Mapping of lymphatic filariasis in loiasis areas: A new strategy shows no evidence for Wuchereria bancrofti endemicity in Cameroon [PDF]
, 2019 Curtis, Kurt C +6 more
core +1 more source
Advanced Microfluidics for Single Cell‐Based Cancer Research
Advanced Science, EarlyView.Cutting‐edge microfluidic platforms are transforming single‐cell cancer research. This review highlights advanced technologies, from droplet microfluidics to tumour‐chips, that enable functional and spatial single‐cell analyses. By integrating biosensing, immune components, and patient‐derived materials, these systems offer new insights into tumour ...
Adriana Carneiro +10 more
wiley +1 more source