Results 71 to 80 of about 9,431,933 (366)

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges

Frontiers in Pharmacology, 2021
A genuine and functional lymphatic vascular system is found in the meninges that sheath the central nervous system (CNS). This unexpected (re)discovery led to a reevaluation of CNS fluid and solute drainage mechanisms, neuroimmune interactions and the ...
S. P. das Neves, Nickoleta Delivanoglou, Sandro Da Mesquita   +2 more
semanticscholar   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Computer-assisted vacuum aspiration mechanical thrombectomy with Lightning Flash allows broader clinical application, enhanced procedural safety, and improved clinical outcomes for the treatment of acute and subacute iliofemoral and central deep venous thrombosis

Journal of Vascular Surgery Cases and Innovative Techniques
We describe our experience with the 16F Lightning Flash vacuum aspiration mechanical thrombectomy system in 25 patients. All patients were treated in a single session with a mean estimated blood loss of 60 mL.
Taimur Saleem, MD, FACS, Seshadri Raju, MD, FACS   +1 more
doaj   +1 more source

Proximal ligation after the side-to-end anastomosis recovery technique for lymphaticovenous anastomosis

Archives of Plastic Surgery, 2019
Background Lymphaticovenous anastomosis is an important surgical treatment for lymphedema, with lymphaticovenous side-to-end anastomosis (LVSEA) and lymphaticovenous end-to-end anastomosis being the most frequently performed procedures.
Yushi Suzuki, Hisashi Sakuma, Jun Ihara, Yusuke Shimizu   +3 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

RevCore thrombectomy device effectively restores venous stent patency by treating iliofemoral caval in-stent restenosis

Journal of Vascular Surgery Cases and Innovative Techniques
Experience with the RevCore mechanical thrombectomy device in a series of 40 patients is described. The device was employed in the treatment of symptomatic in-stent restenosis (ISR) in iliofemoral caval venous stents in these patients.
Taimur Saleem, MD, FACS, Seshadri Raju, MD, FACS   +1 more
doaj   +1 more source

Uro-lymphatic fistula associated with urolithiasis: A case report

Radiology Case Reports, 2022
Uro-lymphatic fistulas are rare, and involve communication between the renal collecting system and the lymphatic system. The disorder is usually caused by the obstruction of lymphatic vessels due to several diseases, leading to chyluria.
Keisuke Tsuboi, Tetsuya Katsumori, Daichi Mino, Hiroaki Kubota, Tatsuya Yoshikawa   +4 more
doaj   +1 more source

Biological functions of CDK5 and potential CDK5 targeted clinical treatments. [PDF]

, 2017
Cyclin dependent kinases are proline-directed serine/threonine protein kinases that are traditionally activated upon association with a regulatory subunit.
Casimiro, Mathew C., Pestell, Richard G., Shupp, Alison   +2 more
core   +2 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source