Results 121 to 130 of about 5,011,546 (295)
Advanced Science, EarlyView.Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha +5 more
wiley +1 more source
A Robust Bio‐Supportive Hydrogel Patch for Full‐Thickness Repair of Gastroesophageal Defects
Advanced Science, EarlyView.Gastroesophageal defect repair remains a formidable clinical challenge plagued by high leakage and life‐threatening complications. We develop a double‐disc, highly crystalline PVA‐based RBS hydrogel patch featuring suture‐free sealing, robust acid/enzyme resistance and mechanical durability.
Xingqi Song +13 more
wiley +1 more source
Clinical application and research progress of lymphovascular markers for breast cancer
Zhongguo linchuang yanjiuBreast cancer has become the most common malignant tumor in women, and its diagnosis and treatment principles mainly depend on the traditional histological and molecular pathological features. However, the systemic metastasis of breast cancer begins when
ZHANG Yuyang, WANG Hongjiang
doaj +1 more source
Lymphangioleiomyoma Cells and Lymphatic Endothelial Cells [PDF]
The American Journal of Pathology, 2010 Kuniaki Seyama +7 more
openaire +1 more source
Advanced Science, EarlyView.An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He +6 more
wiley +1 more source
Meningeal lymphatic-associated brain swelling in acute stroke.
PLoS ONEBrain meninges contain lymphatic vessels that play roles in clearance of extracellular solute in the central nervous system. But, whether and how the system is involved in acute stroke remains to be fully explored.
Rohan Mahesh Patil +9 more
doaj +1 more source
Advanced Science, EarlyView.The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma +12 more
wiley +1 more source
Advanced Science, EarlyView.Where and when should a cancer vaccine be administered? A whole‐body PBPK model demonstrates that systemic immune transport critically determines vaccination efficacy. By simulating how organ‐specific immune interactions influence treatment response, the study provides a quantitative framework for optimizing cancer vaccination strategies.
Mohammad R. Nikmaneshi +2 more
wiley +1 more source
Murine and human lymphatic endothelial cells show similar marker profiles and migratory properties
, 2011 Murine and human lymphatic endothelial cells show similar marker profiles and migratory ...
Elizabeth D Williams (19147639) +1 more
core
Advanced Science, EarlyView.This diagram illustrates that MIIP suppresses tumor‐associated neutrophils infiltration and NETs formation by binding to PKR, which impairs the PKR–IKKβ interaction and attenuates NF‐κB/IL‐8 axis activation, thereby inhibiting colorectal cancer progression. This mechanism highlights a promising therapeutic target for CRC patients.
Jiaxin Li +8 more
wiley +1 more source