Results 61 to 70 of about 111,283 (329)

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source

A robust in vitro model for trans-lymphatic endothelial migration

Scientific Reports, 2017
Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration.
Yanbao Xiong, C. Colin Brinkman, Konrad S Famulski, Emmanuel F. Mongodin, Colin J. Lord, Keli L. Hippen, Bruce R. Blazar, Jonathan S. Bromberg   +7 more
doaj   +1 more source

CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]

, 2011
The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff, Abtahian, Alice Y. Pollitt, Aparicio-Vergara, Bertozzi, Bohmer, Brenda A. Finney, Caetano Reis e Sousa, Carramolino, Caton, Cecile Bénézech, Chagraoui, Cheng, Christou, Clausen, Colonna, Craig E. Hughes, Cueni, de Boer, Diego Mourao-Sa, Edina Schweighoffer, Francesca Barone, Gerard B. Nash, Gustafsson, Hodivala-Dilke, Hughes, Hughes, Humphreys, Ichise, Kate L. Lowe, Kaufmann, Kerrigan, Leyre Navarro-Núñez, Makinen, Martin-Villar, May, Mocsai, Mourao-Sa, Navarro, Navarro, Nicholas Smithers, Nieswandt, Pardridge, Ramirez, Saijo, Schacht, Sebzda, Spalton, Stacey A. Langan, Steve P. Watson, Steve Sheardown, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Suzuki-Inoue, Tammela, Tang, Tiedt, Tober, Turner, Uhrin, Victor L. J. Tybulewicz, Warburton, Watson, Williams, Xie, Xu   +66 more
core   +2 more sources

Lymphatic endothelial progenitors originate from plastic myeloid cells activated by toll-like receptor-4. [PDF]

PLoS ONE, 2017
Myeloid-derived lymphatic endothelial cells (M-LECP) are induced by inflammation and play an important role in adult lymphangiogenesis. However, the mechanisms driving M-LECP differentiation are currently unclear.
Lisa D Volk-Draper, Kelly L Hall, Andrew C Wilber, Sophia Ran   +3 more
doaj   +1 more source

Analysis of Long Non-Coding RNA Expression of Lymphatic Endothelial Cells in Response to Type 2 Diabetes

Cellular Physiology and Biochemistry, 2017
Background: Recent evidence has indicated that long non-coding RNA (lncRNA) is involved in the pathogenesis of type 2 diabetes, but nothing is known about lncRNA expression changes of lymphatic endothelial cells in response to type 2 diabetes.
Min Qi, Qiuhong Zhou, Weiqi Zeng, Minxue Shen, Xiaomin Liu, Chang Luo, Jing Long, Wangqing Chen, Jianglin Zhang, Siyu Yan   +9 more
doaj   +1 more source

Engineering Blood and Lymphatic Microvascular Networks in Fibrin Matrices [PDF]

, 2017
Vascular network engineering is essential for nutrient delivery to tissue-engineered constructs and, consequently, their survival. In addition, the functionality of tissues also depends on tissue drainage and immune cell accessibility, which are the main
Hasenberg, Tobias, Holnthoner, Wolfgang, Knezevic, Lea, Marx, Uwe, Mühleder, Severin, Priglinger, Eleni, Redl, Heinz, Schaupper, Mira, Schimek, Katharina   +8 more
core   +1 more source

Lymphatic Endothelial Cell Progenitors in the Tumor Microenvironment [PDF]

, 2020
Tumor lymphatics play a key role in cancer progression as they are solely responsible for transporting malignant cells to regional lymph nodes (LNs), a process that precedes and promotes systemic lethal spread. It is broadly accepted that tumor lymphatic sprouting is induced mainly by soluble factors derived from tumor-associated macrophages (TAMs) and
Sophia, Ran, Lisa, Volk-Draper
openaire   +2 more sources

Locally Triggered Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic Endothelia

Cell Reports, 2017
Summary: Trafficking cells frequently transmigrate through epithelial and endothelial monolayers. How monolayers cooperate with the penetrating cells to support their transit is poorly understood.
Kari Vaahtomeri, Markus Brown, Robert Hauschild, Ingrid De Vries, Alexander Franz Leithner, Matthias Mehling, Walter Anton Kaufmann, Michael Sixt   +7 more
doaj   +1 more source

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]

, 2012
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Andrea J. White, Butcher, Cardillo, Carragher, Catherine M. Rush, Celli, de Boer, Eric J. Jenkinson, Farr, Fulmer, Gianluca Grassia, Girard, Graham Anderson, Gunn, Hillebrands, Huang, Iain B. McInnes, Itano, James M. Brewer, Karen J. Bryson, Kono, Lane, Leishman, Luther, McNagny, Millington, Pasquale Maffia, Paul Garside, Proudman, Robert A. Benson, Schneider, Smith, Stutzmann, Sumen, Tammela, Tomei, Vivienne B. Gibson, White, Worbs, Yoshida, Zinselmeyer   +40 more
core   +2 more sources

Structure and age-dependent development of the turkey liver: a comparative study of a highly selected meat-type and a wild-type turkey line [PDF]

, 2019
In this study the macroscopic and microscopic structure of the liver of a fast growing, meat-type turkey line (British United turkeys BUT Big 6, n = 25) and a wild-type turkey line (Wild Canadian turkey, n = 48) were compared at the age of 4, 8, 12, 16 ...
Custodis, Pia, Gemeinhardt, Ole, Hafez, Hafez Mohamed, Hirschberg, Ruth M., Hünigen, Hana, Mainzer, Kathleen, Masri, Salah Al, Plendl, Johanna, Richardson, Kenneth C.   +8 more
core   +1 more source