Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment [PDF]
Frontiers in Immunology, 2023 The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja +5 more
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Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium [PDF]
Frontiers in Immunology, 2021 Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri +4 more
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Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function [PDF]
JCI InsightThe expression and functional relevance of the gap junction molecule connexin-45 (Cx45; GJC1) in lymphatic endothelium were not previously known. We found that Cx45 was expressed widely in the endothelium of murine lymphatics, in both valve and nonvalve ...
Michael J. Davis +6 more
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The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review. [PDF]
Cancer Sci, 2022 Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic endothelial cells (LEC), which also mediates immune and cancer cell migration ...
Karinen S, Hujanen R, Salo T, Salem A.
europepmc +2 more sources
Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? [PDF]
Oncogenesis, 2021 Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Karinen S +9 more
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Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis. [PDF]
Front Physiol, 2020 The lymphatic system plays important roles in physiological and pathological conditions. During cancer progression in particular, lymphangiogenesis can exert both positive and negative effects.
Gutierrez-Miranda L, Yaniv K.
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Direct specification of lymphatic endothelium from mesenchymal progenitors. [PDF]
Nat Cardiovasc ResDuring embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Lupu IE +17 more
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Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium. [PDF]
NatureLymphatic capillaries continuously take up interstitial fluid and adapt to resulting changes in vessel calibre1, 2–3. The mechanisms by which the permeable monolayer of loosely connected lymphatic endothelial cells (LECs)4 maintains mechanical stability ...
Schoofs H +21 more
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Direct specification of lymphatic endothelium from non-venous angioblasts
bioRxiv, 2022 The lymphatic vasculature is essential for tissue fluid homeostasis, immune cell surveillance and dietary lipid absorption, and has emerged as a key regulator of organ growth and repair1.
Lupu I +10 more
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Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. [PDF]
Dev Cell, 2019 Summary Endothelial cells (ECs), which line blood and lymphatic vessels, are generally described to come from the lateral plate mesoderm despite experimental evidence for a broader source of origin, including the paraxial mesoderm (PXM).
Stone OA, Stainier DYR.
europepmc +2 more sources