Results 1 to 10 of about 20,544 (88)
The Lymphatic Endothelium in the Context of Radioimmuno-Oncology. [PDF]
Cancers (Basel), 2022 The study of lymphatic tumor vasculature has been gaining interest in the context of cancer immunotherapy. These vessels constitute conduits for immune cells’ transit toward the lymph nodes, and they endow tumors with routes to metastasize to the lymph nodes and, from them, toward distant sites.
Suárez L +2 more
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Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment. [PDF]
Front Immunol, 2023 The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells. Within this complex network, lymphatic endothelial cells (LECs) play a crucial role in regulating immune responses and influencing tumor progression and metastatic dissemination to lymph node and ...
Viúdez-Pareja C +2 more
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Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium. [PDF]
Dev Cell, 2019 Endothelial cells (ECs), which line blood and lymphatic vessels, are generally described to come from the lateral plate mesoderm despite experimental evidence for a broader source of origin, including the paraxial mesoderm (PXM). Current dogma suggests that following specification from mesoderm, local environmental cues establish the distinct molecular
Stone OA, Stainier DYR.
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Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis. [PDF]
Front Physiol, 2020 The lymphatic system plays important roles in physiological and pathological conditions. During cancer progression in particular, lymphangiogenesis can exert both positive and negative effects. While the formation of tumor associated lymphatic vessels correlates with metastatic dissemination, increased severity and poor patient prognosis, the presence ...
Gutierrez-Miranda L, Yaniv K.
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Dendritic cell interactions with lymphatic endothelium. [PDF]
Lymphat Res Biol, 2013 Afferent lymphatic vessels fulfill essential immune functions by transporting leukocytes and lymph-borne antigen to draining lymph nodes (dLNs). An important cell type migrating through lymphatic vessels are dendritic cells (DCs). DCs reside in peripheral tissues like the skin, where they take up antigen and transport it via the lymphatic vascular ...
Russo E, Nitschké M, Halin C.
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Direct specification of lymphatic endothelium from mesenchymal progenitors. [PDF]
Nat Cardiovasc ResAbstract During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Lupu IE +17 more
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Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex-dependent manner. [PDF]
Physiol RepAbstractThe lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells. Pannexin1 (Panx1) channels allow for the passage of ions and small metabolites between the cytosol and extracellular environment.
Ehrlich A +5 more
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microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation. [PDF]
Front Immunol, 2017 microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress. The lymphatic system is a large vascular network that actively regulates the immune response through antigen ...
Yee D, Coles MC, Lagos D.
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Culturing purifies murine lymph node lymphatic endothelium. [PDF]
Lymphat Res Biol, 2014 Lymph node (LN) lymphatic sinuses transport lymph, cells, and antigens from the periphery through the LN. The lymphatic endothelium lining these sinuses appears to be an important contributor to the lymph node immune response. It has been challenging to obtain sufficient LN lymphatic endothelial cells for investigation of their functions, as they are ...
Jordan-Williams KL, Ruddell A.
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Emerging roles of lymphatic endothelium in regulating adaptive immunity. [PDF]
J Clin Invest, 2014 Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes.
Card CM, Yu SS, Swartz MA.
europepmc +5 more sources