Results 1 to 10 of about 273 (109)

Hematopoietic stem cells contribute to lymphatic endothelium.

open access: yesPLoS ONE, 2008
BackgroundAlthough the lymphatic system arises as an extension of venous vessels in the embryo, little is known about the role of circulating progenitors in the maintenance or development of lymphatic endothelium.
Shuguang Jiang   +6 more
doaj   +3 more sources

Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment

open access: yesFrontiers in Immunology, 2023
The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja   +5 more
doaj   +3 more sources

Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium

open access: yesFrontiers in Immunology, 2021
Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Robert Hauschild   +2 more
exaly   +3 more sources

Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex‐dependent manner

open access: yesPhysiological Reports
The lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells.
Avigail Ehrlich   +5 more
doaj   +4 more sources

Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function

open access: yesJCI Insight
The expression and functional relevance of the gap junction molecule connexin-45 (Cx45; GJC1) in lymphatic endothelium were not previously known. We found that Cx45 was expressed widely in the endothelium of murine lymphatics, in both valve and nonvalve ...
Michael J. Davis   +6 more
doaj   +3 more sources

Transcription Factor Control of Lymphatic Quiescence and Maturation of Lymphatic Neovessels in Development and Physiology

open access: yesFrontiers in Physiology, 2021
The lymphatic system is a vascular system comprising modified lymphatic endothelial cells, lymph nodes and other lymphoid organs. The system has diverse, but critical functions in both physiology and pathology, and forms an interface between the blood ...
Zarah B. Tabrizi   +4 more
doaj   +1 more source

Lymphatic endothelium [PDF]

open access: yesThe Journal of Cell Biology, 2003
The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged.
Pepper, Michael S., Skobe, Mihaela
openaire   +2 more sources

Lymphatic Clearance of Immune Cells in Cardiovascular Disease

open access: yesCells, 2021
Recent advances in our understanding of the lymphatic system, its function, development, and role in pathophysiology have changed our views on its importance. Historically thought to be solely involved in the transport of tissue fluid, lipids, and immune
Christophe Ravaud   +4 more
doaj   +1 more source

The Lymphatic Endothelium in the Context of Radioimmuno-Oncology

open access: yesCancers, 2022
The study of lymphatic tumor vasculature has been gaining interest in the context of cancer immunotherapy. These vessels constitute conduits for immune cells’ transit toward the lymph nodes, and they endow tumors with routes to metastasize to the lymph nodes and, from them, toward distant sites.
Lucía Suárez   +2 more
openaire   +3 more sources

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