Results 1 to 10 of about 272,241 (180)

Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium [PDF]

Frontiers in Immunology, 2021
Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri, Kari Vaahtomeri, Christine Moussion, Robert Hauschild, Michael Sixt   +4 more
doaj   +4 more sources

Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? [PDF]

Oncogenesis, 2021
Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Karinen S, Juurikka K, Hujanen R, Wahbi W, Hadler-Olsen E, Svineng G, Eklund KK, Salo T, Åström P, Salem A.   +9 more
europepmc   +4 more sources

Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment [PDF]

Frontiers in Immunology, 2023
The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja, Cristina Viúdez-Pareja, Ewa Kreft, Ewa Kreft, Melissa García-Caballero, Melissa García-Caballero   +5 more
doaj   +3 more sources

The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review. [PDF]

Cancer Sci, 2022
Lymphangiogenesis is a key process in cancer development and metastasis. Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) is a widely used marker for lymphatic endothelial cells (LEC), which also mediates immune and cancer cell migration ...
Karinen S, Hujanen R, Salo T, Salem A.
europepmc   +3 more sources

microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation. [PDF]

Front Immunol, 2017
microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress.
Yee D, Coles MC, Lagos D.
europepmc   +4 more sources

Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium. [PDF]

Microcirculation, 2018
Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects
Lee Y, Chakraborty S, Meininger CJ, Muthuchamy M.   +3 more
europepmc   +4 more sources

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium. [PDF]

Nature
Lymphatic capillaries continuously take up interstitial fluid and adapt to resulting changes in vessel calibre1, 2–3. The mechanisms by which the permeable monolayer of loosely connected lymphatic endothelial cells (LECs)4 maintains mechanical stability ...
Schoofs H, Daubel N, Schnabellehner S, Grönloh MLB, Palacios Martínez S, Halme A, Marks AM, Jeansson M, Barcos S, Brakebusch C, Benedito R, Engelhardt B, Vestweber D, Gaengel K, Linsenmeier F, Schürmann S, Saharinen P, van Buul JD, Friedrich O, Smith RS, Majda M, Mäkinen T.   +21 more
europepmc   +4 more sources

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. [PDF]

Elife, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM.   +17 more
europepmc   +4 more sources

Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis [PDF]

Frontiers in Physiology, 2020
The lymphatic system plays important roles in physiological and pathological conditions. During cancer progression in particular, lymphangiogenesis can exert both positive and negative effects.
Laura Gutierrez-Miranda, Karina Yaniv
doaj   +3 more sources

Direct specification of lymphatic endothelium from mesenchymal progenitors. [PDF]

Nat Cardiovasc Res
During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Lupu IE, Grainger DE, Kirschnick N, Weischer S, Zhao E, Martinez-Corral I, Schoofs H, Vanhollebeke M, Jones G, Godwin J, Forrow A, Lahmann I, Riley PR, Zobel T, Alitalo K, Mäkinen T, Kiefer F, Stone OA.   +17 more
europepmc   +4 more sources