Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium [PDF]
Frontiers in Immunology, 2021 Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri +4 more
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Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. [PDF]
Elife, 2020 Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood.
Engelbrecht E +15 more
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Cellular Origins of the Lymphatic Endothelium: Implications for Cancer Lymphangiogenesis [PDF]
Frontiers in Physiology, 2020 The lymphatic system plays important roles in physiological and pathological conditions. During cancer progression in particular, lymphangiogenesis can exert both positive and negative effects.
Laura Gutierrez-Miranda, Karina Yaniv
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Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium. [PDF]
J Biol Chem, 2016 The lymphatic vessel endothelial receptor LYVE-1 is implicated in the uptake of hyaluronan (HA) and trafficking of leukocytes to draining lymph nodes. Yet LYVE-1 has only weak affinity for hyaluronan and depends on receptor clustering and higher order ...
Banerji S +8 more
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Dendritic cell interactions with lymphatic endothelium. [PDF]
Lymphat Res Biol, 2013 Afferent lymphatic vessels fulfill essential immune functions by transporting leukocytes and lymph-borne antigen to draining lymph nodes (dLNs). An important cell type migrating through lymphatic vessels are dendritic cells (DCs).
Russo E, Nitschké M, Halin C.
europepmc +4 more sources
Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex‐dependent manner [PDF]
Physiological ReportsThe lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells.
Avigail Ehrlich +5 more
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mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn’s Disease [PDF]
Cells, 2019 Crohn’s disease (CD) is a chronic inflammatory condition that can affect different portions of the gastrointestinal tract. Lymphatic drainage was demonstrated to be dysfunctional in CD pathogenesis, ultimately causing the failure of the resolution ...
Federica Ungaro +13 more
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Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium. [PDF]
Eur J Immunol, 2015 Secondary lymphoid stroma performs far more functions than simple structural support for lymphoid tissues, providing a host of soluble and membrane‐bound cues to trafficking leukocytes during inflammation and homeostasis.
Kedl RM, Tamburini BA.
europepmc +4 more sources
Emerging roles of lymphatic endothelium in regulating adaptive immunity. [PDF]
J Clin Invest, 2014 Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines,
Card CM, Yu SS, Swartz MA.
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Am J Physiol Cell Physiol, 2015 The lymphatics have emerged as critical players in the progression and resolution of inflammation. The goal of this study was to identify specific microRNAs (miRNAs) that regulate lymphatic inflammatory processes.
Chakraborty S +3 more
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