Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex‐dependent manner [PDF]
Physiological ReportsThe lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells.
Avigail Ehrlich +5 more
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Connexin-45 is expressed in mouse lymphatic endothelium and required for lymphatic valve function [PDF]
JCI InsightThe expression and functional relevance of the gap junction molecule connexin-45 (Cx45; GJC1) in lymphatic endothelium were not previously known. We found that Cx45 was expressed widely in the endothelium of murine lymphatics, in both valve and nonvalve ...
Michael J. Davis +6 more
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Shape and Function of Interstitial Chemokine CCL21 Gradients Are Independent of Heparan Sulfates Produced by Lymphatic Endothelium [PDF]
Frontiers in Immunology, 2021 Gradients of chemokines and growth factors guide migrating cells and morphogenetic processes. Migration of antigen-presenting dendritic cells from the interstitium into the lymphatic system is dependent on chemokine CCL21, which is secreted by ...
Kari Vaahtomeri +4 more
doaj +3 more sources
The Lymphatic Endothelium in the Context of Radioimmuno-Oncology. [PDF]
Cancers (Basel), 2022 The study of lymphatic tumor vasculature has been gaining interest in the context of cancer immunotherapy. These vessels constitute conduits for immune cells’ transit toward the lymph nodes, and they endow tumors with routes to metastasize to the lymph nodes and, from them, toward distant sites.
Suárez L +2 more
europepmc +6 more sources
Culturing purifies murine lymph node lymphatic endothelium. [PDF]
Lymphat Res Biol, 2014 Lymph node (LN) lymphatic sinuses transport lymph, cells, and antigens from the periphery through the LN. The lymphatic endothelium lining these sinuses appears to be an important contributor to the lymph node immune response. It has been challenging to obtain sufficient LN lymphatic endothelial cells for investigation of their functions, as they are ...
Jordan-Williams KL, Ruddell A.
europepmc +5 more sources
Immunomodulatory properties of the lymphatic endothelium in the tumor microenvironment [PDF]
Frontiers in Immunology, 2023 The tumor microenvironment (TME) is an intricate complex and dynamic structure composed of various cell types, including tumor, stromal and immune cells.
Cristina Viúdez-Pareja +5 more
doaj +4 more sources
Direct specification of lymphatic endothelium from mesenchymal progenitors. [PDF]
Nat Cardiovasc ResAbstract During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs.
Lupu IE +17 more
europepmc +9 more sources
Emerging roles of lymphatic endothelium in regulating adaptive immunity. [PDF]
J Clin Invest, 2014 Emerging research on the roles of stromal cells in modulating adaptive immune responses has included a new focus on lymphatic endothelial cells (LECs). LECs are presumably the first cells that come into direct contact with peripheral antigens, cytokines, danger signals, and immune cells travelling from peripheral tissues to lymph nodes.
Card CM, Yu SS, Swartz MA.
europepmc +5 more sources
The Journal of Cell Biology, 2003 The lymphatic microvasculature is uniquely adapted for the continuous removal of interstitial fluid and proteins, and is an important point of entry for leukocytes and tumor cells. The traditional view that lymphatic capillaries are passive participants in these tasks is currently being challenged.
Michael S. Pepper, Mihaela Skobe
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The inflammatory response of lymphatic endothelium [PDF]
Angiogenesis, 2013 ISSN:1573 ...
David Aebischer +2 more
openalex +7 more sources