Results 11 to 20 of about 400,241 (273)

microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation. [PDF]

Front Immunol, 2017
microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress.
Yee D, Coles MC, Lagos D.
europepmc   +4 more sources

Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta. [PDF]

Elife, 2020
Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood.
Engelbrecht E, Levesque MV, He L, Vanlandewijck M, Nitzsche A, Niazi H, Kuo A, Singh SA, Aikawa M, Holton K, Proia RL, Kono M, Pu WT, Camerer E, Betsholtz C, Hla T.   +15 more
europepmc   +2 more sources

Hematopoietic stem cells contribute to lymphatic endothelium.

PLoS ONE, 2008
BackgroundAlthough the lymphatic system arises as an extension of venous vessels in the embryo, little is known about the role of circulating progenitors in the maintenance or development of lymphatic endothelium.
Shuguang Jiang, Alexis S Bailey, Devorah C Goldman, John R Swain, Melissa H Wong, Philip R Streeter, William H Fleming   +6 more
doaj   +2 more sources

Apelin modulates pathological remodeling of lymphatic endothelium after myocardial infarction. [PDF]

JCI Insight, 2017
Lymphatic endothelium serves as a barrier to control fluid balance and immune cell trafficking to maintain tissue homeostasis. Long-term alteration of lymphatic vasculature promotes edema and fibrosis, which is an aggravating factor in the onset of ...
Tatin F, Renaud-Gabardos E, Godet AC, Hantelys F, Pujol F, Morfoisse F, Calise D, Viars F, Valet P, Masri B, Prats AC, Garmy-Susini B.   +11 more
europepmc   +2 more sources

mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease. [PDF]

Cells, 2019
Crohn’s disease (CD) is a chronic inflammatory condition that can affect different portions of the gastrointestinal tract. Lymphatic drainage was demonstrated to be dysfunctional in CD pathogenesis, ultimately causing the failure of the resolution of ...
Ungaro F, Garlatti V, Massimino L, Spinelli A, Carvello M, Sacchi M, Spanò S, Colasante G, Valassina N, Vetrano S, Malesci A, Peyrin-Biroulet L, Danese S, D'Alessio S.   +13 more
europepmc   +2 more sources

Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium. [PDF]

Microcirculation, 2018
Lymphatic vessel dysfunction and increased lymph leakage have been directly associated with several metabolic diseases. However, the underlying cellular mechanisms causing lymphatic dysfunction have not been determined. Aberrant insulin signaling affects
Lee Y, Chakraborty S, Meininger CJ, Muthuchamy M.   +3 more
europepmc   +2 more sources

Role of Lymphatic Endothelium in Vascular Escape of Engineered Human Breast Microtumors. [PDF]

Cell Mol Bioeng, 2022
Seibel AJ, Kelly OM, Dance YW, Nelson CM, Tien J.   +4 more
europepmc   +2 more sources

Lymphatic endothelium stimulates melanoma metastasis and invasion via MMP14-dependent Notch3 and β1-integrin activation. [PDF]

Elife, 2018
Lymphatic invasion and lymph node metastasis correlate with poor clinical outcome in melanoma. However, the mechanisms of lymphatic dissemination in distant metastasis remain incompletely understood.
Pekkonen P, Alve S, Balistreri G, Gramolelli S, Tatti-Bugaeva O, Paatero I, Niiranen O, Tuohinto K, Perälä N, Taiwo A, Zinovkina N, Repo P, Icay K, Ivaska J, Saharinen P, Hautaniemi S, Lehti K, Ojala PM.   +17 more
europepmc   +2 more sources

Pannexin1 deletion in lymphatic endothelium affects lymphatic function in a sex‐dependent manner [PDF]

Physiological Reports
The lymphatic network of capillaries and collecting vessels ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells.
Avigail Ehrlich, Graziano Pelli, Robert Pick, Linda Clochard, Filippo Molica, Brenda R. Kwak   +5 more
doaj   +2 more sources

Antigen archiving by lymph node stroma: A novel function for the lymphatic endothelium. [PDF]

Eur J Immunol, 2015
Secondary lymphoid stroma performs far more functions than simple structural support for lymphoid tissues, providing a host of soluble and membrane‐bound cues to trafficking leukocytes during inflammation and homeostasis.
Kedl RM, Tamburini BA.
europepmc   +2 more sources