Results 111 to 120 of about 23,732 (269)

A robust in vitro model for trans-lymphatic endothelial migration

Scientific Reports, 2017
Trans-endothelial migration (TEM) is essential for leukocyte circulation. While much is known about trans-blood endothelial migration, far less is known about trans-lymphatic endothelial migration.
Yanbao Xiong, C. Colin Brinkman, Konrad S Famulski, Emmanuel F. Mongodin, Colin J. Lord, Keli L. Hippen, Bruce R. Blazar, Jonathan S. Bromberg   +7 more
doaj   +1 more source

The prognostic influence of lymphatic endothelium-specific hyaluronan receptor 1 in cancer: A systematic review. [PDF]

Cancer Sci, 2022
Karinen S, Hujanen R, Salo T, Salem A.
europepmc   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult Brugia malayi. [PDF]

PLoS Negl Trop Dis, 2022
Marriott AE, Furlong Silva J, Pionnier N, Sjoberg H, Archer J, Steven A, Kempf D, Taylor MJ, Turner JD.   +8 more
europepmc   +1 more source

The β-Chemokine Receptor D6 Is Expressed by Lymphatic Endothelium and a Subset of Vascular Tumors [PDF]

, 2001
Robert J. B. Nibbs, Ernst Kriehuber, Paul Ponath, David Parent, Shixin Qin, John D. Campbell, A. Stewart Henderson, Dontscho Kerjaschki, Dieter Maurer, Gerard J. Graham, Antal Rot   +10 more
openalex   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Dataset related to article "Lymphatic endothelium contributes to colorectal cancer growth via the soluble matrisome component GDF11."

, 2020
Federica Ungaro, Piergiuseppe Colombo, Luca Massimino, Ugolini GS, Carmen Correale, Marco Rasponi, Valentina Garlatti, Federica Rubbino, Carlotta Tacconi, Paola Spaggiari, Antonino Spinelli, Michele Carvello, Matteo Sacchi, Salvatore Spanò, Stefania Vetrano, Alberto Malesci, Laurent Peyrin‐Biroulet, Silvio Danese, Silvia D’Alessio   +18 more
openalex   +2 more sources

Nano‐Enabled Systemic Delivery of STING Agonist by Engineered Silicasome for Potent Antitumor Immunotherapy

Advanced Science, EarlyView.
Engineered mesoporous silica nanoparticles (Silicasomes) enable systemic delivery of the STING agonist ADU‐S100, overcoming the instability and toxicity that limit cyclic dinucleotides to local administration. By enhancing tumor accumulation, activating systemic antitumor immunity, and remodeling the tumor immune microenvironment, these nanoparticles ...
Wenjing Zhou, Yuting Li, Xudong Sun, Honghong Yang, Xiayu Shi, Lijia Yao, Jinhong Jiang, Erli Wang, Haoyang Wang, Yi Wei, Xiangsheng Liu   +10 more
wiley   +1 more source

Dataset related to article "mTOR-Dependent Stimulation of IL20RA Orchestrates Immune Cell Trafficking through Lymphatic Endothelium in Patients with Crohn's Disease."

, 2020
Federica Ungaro, Valentina Garlatti, Luca Massimino, Antonino Spinelli, Michele Carvello, Matteo Sacchi, Salvatore Spanò, Gaia Colasante, Nicholas Valassina, Stefania Vetrano, Alberto Malesci, Laurent Peyrin‐Biroulet, Silvio Danese, Silvia D’Alessio   +13 more
openalex   +3 more sources