microRNAs in the Lymphatic Endothelium: Master Regulators of Lineage Plasticity and Inflammation. [PDF]
Front Immunol, 2017 microRNAs (miRNAs) are highly conserved, small non-coding RNAs that regulate gene expression at the posttranscriptional level. They have crucial roles in organismal development, homeostasis, and cellular responses to pathological stress.
Yee D, Coles MC, Lagos D.
europepmc +2 more sources
CD44 Binds to Macrophage Mannose Receptor on Lymphatic Endothelium and Supports Lymphocyte Migration via Afferent Lymphatics [PDF]
Circulation Research, 2013 Rationale: Macrophage mannose receptor (MRC) is one of the few molecules known to be involved in lymphocyte trafficking via the lymphatic vessels. In endothelial cells of efferent lymphatics, it binds L-selectin on lymphocytes.
Marko Salmi +4 more
openalex +2 more sources
Culturing purifies murine lymph node lymphatic endothelium. [PDF]
Lymphat Res Biol, 2014 BACKGROUND Lymph node (LN) lymphatic sinuses transport lymph, cells, and antigens from the periphery through the LN. The lymphatic endothelium lining these sinuses appears to be an important contributor to the lymph node immune response.
Jordan-Williams KL, Ruddell A.
europepmc +2 more sources
Gap junction coupling is required for tumor cell migration through lymphatic endothelium. [PDF]
Arterioscler Thromb Vasc Biol, 2015 Objective— The lymphatic vasculature is a well-established conduit for metastasis, but the mechanisms by which tumor cells interact with lymphatic endothelial cells (LECs) to facilitate escape remain poorly understood.
Karpinich NO, Caron KM.
europepmc +2 more sources
Hematopoietic stem cells contribute to lymphatic endothelium. [PDF]
PLoS ONE, 2008 Although the lymphatic system arises as an extension of venous vessels in the embryo, little is known about the role of circulating progenitors in the maintenance or development of lymphatic endothelium.
Shuguang Jiang +6 more
doaj +3 more sources
Histamine as an Endothelium-Derived Relaxing Factor in Aged Mesenteric Lymphatic Vessels [PDF]
Lymphatic Research and Biology, 2017 BACKGROUND Knowledge of the mechanisms by which aging affects contracting lymphatic vessels remains incomplete; therefore, the functional role of histamine in the reaction of aged lymphatic vessels to increases in flow remains unknown.
Irina Tsoy Nizamutdinova +4 more
openalex +2 more sources
Nestin as a Marker Beyond Angiogenesis—Expression Pattern in Haemangiomas and Lymphangiomas [PDF]
BiomedicinesBackground: The intermediate filament nestin was first described in stem and progenitor cells of neural and mesenchymal origin. Additionally, it is expressed in endothelial cells during wound healing and tumorigenesis.
Andreas Mamilos +11 more
doaj +2 more sources
A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium. [PDF]
Lymphat Res Biol, 2012 BACKGROUND Lymphovascular invasion (LVI) is an important step in the metastatic cascade; tumor cell migration and adhesion to blood and lymphatic vessels is followed by invasion through the vessel wall and subsequent systemic spread.
Safuan S, Storr SJ, Patel PM, Martin SG.
europepmc +2 more sources
The Lymphatic Endothelium in the Context of Radioimmuno-Oncology. [PDF]
Cancers (Basel), 2022 Suárez L +2 more
europepmc +3 more sources
MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity. [PDF]
PLoS Neglected Tropical DiseasesLymphatic filariasis (LF) is a neglected tropical disease affecting over 51 million people in 72 endemic countries. Causative agents of LF are mosquito-borne parasitic nematodes Wuchereria bancrofti, Brugia malayi, and Brugia timori.
Hailey Johnson +4 more
doaj +2 more sources