Results 51 to 60 of about 40,744 (225)

Lymph nodes go with the flow [PDF]

, 2018
In this issue, Bovay et al. (https://doi.org/10.1084/jem.20180217) invoke a compelling model of interplay between the venous and lymphatic vasculature in regulating the developmental genesis and early expansion of LNs.
Czepielewski, Rafael S, Randolph, Gwendalyn J   +1 more
core   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

The lymphatic endothelium in the context of radioimmuno-oncology

, 2023
Simple Summary The introduction of immunotherapy within the usual strategies for cancer treatment has meant an enormous advance in the survival of patients with very restrictive prognoses. However, a high percentage of patients still cannot benefit from it.
Rouzaut, A. (Ana), Rodriguez-Ruiz, M.E. (María Esperanza), González, L. (Lucía)   +2 more
openaire   +1 more source

Preexisting Lymphatic Endothelium but not Endothelial Progenitor Cells Are Essential for Tumor Lymphangiogenesis and Lymphatic Metastasis [PDF]

Cancer Research, 2004
Abstract Endothelial progenitor cells have been shown to contribute to angiogenesis in various tumor models. Here, we have studied the relative contributions of bone marrow (BM)-derived endothelial progenitors and pre-existing lymphatic vessels to tumor lymphangiogenesis. We did not find significant incorporation of genetically marked BM-
Marika J. Karkkainen, Taija Makinen, Iiro Rajantie, Maritta Ilmonen, Kari Alitalo, Petri Salven, Paula Haiko, Yulong He   +7 more
openaire   +3 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Comparison of the diagnostic accuracy of lymphatic endothelium markers: Bayesian approach [PDF]

Modern Pathology, 2005
Tumor lymphatic density is evaluated by means of specific lymphatic endothelium markers, and is a potential predictor of clinically meaningful outcomes. There are many claims on the postulated superiority of some of these markers to identify lymphatics, always in the absence of quantitative data.
Panayiotis A. Kyzas, Evangelos Evangelou, Thomas A Trikalinos, Thomas A Trikalinos   +3 more
openaire   +4 more sources

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. [PDF]

, 2020
Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular immune response comprising innate and adaptive phases. When the ocular immune system is excessively stimulated and/or immunoregulatory mechanisms are disrupted, the ...
Lin, Meng C, Neri, Piergiorgio, Perez, Victor L, Periman, Laura M, Saban, Daniel R   +4 more
core   +1 more source

The Road Less Traveled: Regulation of Leukocyte Migration Across Vascular and Lymphatic Endothelium by Galectins [PDF]

, 2010
Leukocyte entry from the blood into inflamed tissues, exit into the lymphatics, and migration to regional lymph nodes are all crucial processes for mounting an effective adaptive immune response.
AB Dietz, AD Luster, AG Harmsen, BA Maletto, BN Stillman, C Colnot, CD Gil, CD Gil, CF Brewer, CR Mackay, D Alvarez, DC Anderson, DK Hsu, DK Hsu, FT Liu, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GJ Randolph, GR Vasta, H Sano, H Yamamoto, IJ Chen, J Almkvist, J He, J Nieminen, J Saegusa, JA Fulcher, JA Fulcher, JD Hernandez, JT Nguyen, K Furukawa, K Ley, KE Pace, LA Earl, LA Earl, LA Johnson, LA Johnson, LG Baum, Linda G. Baum, LN Cueni, LN Cueni, LV Norling, M Amano, M Demetriou, M Hirashima, M La, M Nachtigal, M Nagae, MA Daniels, MA Daniels, MA Pozo del, MK Wild, ML Hermiston, ML Thomas, MT Elola, N Ahmad, N Demotte, N Matsushita, N Rubinstein, NL Perillo, OB Garner, Q Huang, RI Zuberi, S Bi, S Bi, S Rifat, S Sato, Sandra Thiemann, SD Liu, SK Cha, SR Stowell, SR Stowell, V Abadie, VL Thijssen, VS Erickson, WN Haining, X Song, Y Tsuboi   +79 more
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source