Results 41 to 50 of about 13,484 (205)

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Critical role of keratinocytes and protease‐activated receptor 2 in secondary lymphedema development

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Activated keratinocytes play an important role in the early stage of the pathophysiology of secondary lymphedema through PAR2 signaling. Lymphatic injury‐induced protease activation stimulates keratinocyte PAR2 signaling, driving hyperkeratosis and Th2 inflammation, which can be therapeutically attenuated by teriflunomide. Abstract Background Secondary
Hyeung Ju Park, Sarit Pal, Xizhao Chen, Jinyeon Shin, Gabriela D. García Nores, Jung Eun Baik, Annica Stull‐Lane, Abraham J. Book, Cristina C. Clement, Elizabeth M. Encarnacion, Mark G. Klang, Elyn Riedel, Tafadzwa L. Chaunzwa, Geoffrey E. Hespe, Laura Santambrogio, Michelle Coriddi, Joseph H. Dayan, Babak J. Mehrara, Raghu P. Kataru   +18 more
wiley   +1 more source

Proinflammatory Cytokine Gene Expression by Murine Macrophages in Response to Brugia malayi Wolbachia Surface Protein

Mediators of Inflammation, 2007
Wolbachia, an endosymbiotic bacterium found in most species of filarial parasites, is thought to play a significant role in inducing innate inflammatory responses in lymphatic filariasis
Chantima Porksakorn, Surang Nuchprayoon, Kiwon Park, Alan L. Scott   +3 more
doaj   +1 more source

Soil-transmitted helminthiasis in four districts in Bangladesh: household cluster surveys of prevalence and intervention status

BMC Public Health, 2020
Background In 2016, after 8 years of twice-annual nationwide preventive chemotherapy (PC) administration to school-age children (SAC), the Bangladesh Ministry of Health & Family Welfare (MOHFW) sought improved impact and intervention monitoring data to ...
Stacy L. Davlin, Alexander H. Jones, Sanya Tahmina, Abdullah Al Kawsar, Anand Joshi, Sazid I. Zaman, Muhammad M. Rahman, Bozena M. Morawski, Michael S. Deming, Rubina Imtiaz, Mohammad J. Karim   +10 more
doaj   +1 more source

Ivermectin Toxicity in Humans and Animals: Clinical Spectrum, Mechanisms, and Management

Journal of Applied Toxicology, Volume 46, Issue 6, Page 1856-1870, June 2026.
ABSTRACT Ivermectin is a widely used macrocyclic lactone with established efficacy against a broad range of parasitic infections in humans and animals and a long‐standing reputation for clinical safety. However, increasing evidence indicates that ivermectin can produce clinically relevant toxicity under specific conditions, particularly involving the ...
Serkan Yilmaz, Bayram Göktaş, İlker Ateş, Mustafa Çelik   +3 more
wiley   +1 more source

Assay strategies for the discovery and validation of therapeutics targeting Brugia pahangi Hsp90 [PDF]

, 2010
The chemotherapy of lymphatic filariasis relies upon drugs such as diethylcarbamazine and ivermectin that largely target the microfilarial stages of the parasite, necessitating continued treatment over the long reproductive life span of the adult worm ...
Gillan, V., O'Neill, K., Devaney, E., Chiosis Gabriela, Kerry O'Neill, Taldone, T., Devaney Eileen, Taldone Tony, Patel, P., O'Neill Kerry, Rodina, A., Kirsty Maitland, Chiosis, G., Maitland Kirsty, Anna Rodina, Rodina Anna, Victoria Gillan, Tony Taldone, Pallav Patel, Gillan Victoria, Sun, W., Eileen Devaney, Patel Pallav, Weilin Sun, Gabriela Chiosis, Maitland, K., Sun Weilin   +26 more
core   +1 more source

Application of the Filariasis CELISA Antifilarial IgG𝟒 Antibody Assay in Surveillance in Lymphatic Filariasis Elimination Programmes in the South Pacific

Journal of Tropical Medicine, 2011
Elimination of lymphatic filariasis (LF) in the Pacific Island Countries and Territories (PICT) has been defined as
Hayley Joseph, Fuatai Maiava, Take Naseri, Fasihah Taleo, Malakai ‘Ake, Corinne Capuano, Wayne Melrose   +6 more
doaj   +1 more source

“Reactions in Leprosy: Updated Insights Into Pathophysiology, Clinical Spectrum, and Therapeutic Approaches—A Narrative Review”

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Reaction in leprosy is an immune‐mediated acute inflammatory episodes that occur in the natural course of Hansen's disease. Reaction can occur before, during, or after starting multidrug therapy and is a major cause of nerve damage, morbidity, and disability in affected individuals.
Bhaskar Gupta, Manesha Singh, Mohamad Goldust, Kinnor Das, Surajit Gorai, Prajwal Pudasaini, Seema Sitaula, Achyut Pokhrel, Esna Thapa, Sunil Jaiswal   +9 more
wiley   +1 more source

The impact of mass drug administration and long-lasting insecticidal net distribution on Wuchereria bancrofti infection in humans and mosquitoes: an observational study in northern Uganda. [PDF]

, 2011
BACKGROUND: Lymphatic filariasis (LF) in Uganda is caused by Wuchereria bancrofti and transmitted by anopheline mosquitoes. The mainstay of elimination has been annual mass drug administration (MDA) with ivermectin and albendazole, targeted to endemic ...
Ambrose Onapa, Opio, Tom, Tansy Edwards, Brooker, Simon, Kolaczinski, Jan H, Tom Opio, Ashton, Ruth A, Simon Brooker, Daniel J Kyabayinze, Jan H Kolaczinski, Kyabayinze, Daniel J, Ruth A Ashton, Onapa, Ambrose, Edwards, Tansy, Gabriel Matwale, Auma, Anna, Matwale, Gabriel, Anna Auma   +17 more
core   +1 more source

Resource Availability Overrides Predator Presence in Mosquito Oviposition Habitat Selection

Entomologia Experimentalis et Applicata, Volume 174, Issue 5, Page 424-435, May 2026.
Gravid Culex quinquefasciatus balance predation risk against resource availability when selecting oviposition sites. In outdoor mesocosms, we factorially manipulated sugarcane jaggery (resource) and notonectid predators (adult vs. nymph; caged vs. free‐swimming) across 2 years.
Arpita Dalal, Ross N. Cuthbert, Suman Dey, Nabajyoti Biswas, Susmita Gupta, Jaimie T. A. Dick   +5 more
wiley   +1 more source