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Molecular mechanisms and imaging of lymphatic metastasis
Experimental Cell Research, 2013In many types of cancer, tumors metastasize through the lymphatic system to draining lymph nodes. These sentinel lymph nodes have gained increased attention as a prognostic indicator for the severity of the disease, leading to the sentinel lymph node mapping and biopsy procedure to be accepted as standard-of-care for breast cancer and melanoma. However,
Proulx ST, Detmar M
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Experimental models of lymphatic metastasis [PDF]
, 1982 The common human cancers spread by lymphatic metastasis [1], but most experimental work on metastasis has been done with models of hematogenous metastasis since this occurs much more readily in animal systems. The classic work on lymphatic metastasis was that of Zeidman and Buss [2], but until 1970 the field was relatively unexplored.
I. Carr, J. Carr
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Gene sequencing and expression of Raf-1 in lymphatic metastasis of hypopharyngeal carcinoma
Cancer Biomarkers, 2020OBJECTIVE: We performed differential gene screening for lymphatic metastasis of hypopharyngeal carcinoma by gene sequencing. We also aimed to investigate the expression and clinicopathological significance of the screened gene in hypopharyngeal carcinoma
Yanshi Li, T. Lu, G. Hu
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Lymphatic Metastasis of Neoplasms
1983Human cancers commonly metastasize by the lymphatics to draining lymph nodes. The existence of lymphatic vessels has been known since the observations of Aselli in 1622 and the fact that cancer can spread to lymph nodes was “well-known”to Pearson in 1793 (reviewed by Mayerson, 1969; Onuigbo, 1972).
Jean Carr, Ian Carr
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Adhesion mechanisms in lymphatic metastasis
Cancer and Metastasis Review, 1991The role of cellular adhesion in regional lymph node metastasis of solid tumors has been investigated. The data reviewed is based on studies in four different tumor models of human, rat and murine origin. An in vitro assay measuring tumor cell attachment to cryostat sections of normal peripheral lymph nodes, obtained from the species of tumor origin ...
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Targeted Treatment for Lymphedema and Lymphatic Metastasis
Annals of the New York Academy of Sciences, 2008The presence of lymphatic vessels has been known for centuries, but the key players regulating the lymphatic vessel growth and function have only been discovered during the recent decade. The lymphatic vasculature is essential for maintenance of normal fluid balance and for the immune response.
Tomi Tervala +2 more
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Gastrointestinal cancer metastasis and lymphatic advancement
Surgery Today, 2010The role of angiogenesis in the growth of solid tumors is well established, but the role of lymphatic vessels and the relationship between lymphangiogenesis and tumor spread are less clear. Recently, the molecular pathway that signals lymphangiogenesis and specific markers for lymphatic endothelium have been discovered; however, the lymphatic pathway ...
Takayuki Tanaka +5 more
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Lymphatic endothelium: a new frontier of metastasis research [PDF]
Nature Cell Biology, 2002 The vascular endothelium is a dynamic tissue with many active functions. Until recently, endothelial cell (EC) biology studies have used cultured ECs from various organs; these cell lines are considered representative of the blood vascular endothelium.
Kari Alitalo +2 more
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The evolving role of lymphatics in cancer metastasis
Current Opinion in Immunology, 2018While the link between the lymphatic system and the metastatic spread of cancer is centuries old, understanding of the underlying mechanisms is still evolving. Lymphatic vessels provide a route for tumour cells to reach regional lymph nodes (LNs), which is prognostic of distant organ metastasis and poor survival. However, genomic analyses of metastatic
Marc G. Achen +3 more
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Lymphatic function, lymphangiogenesis, and cancer metastasis
Microscopy Research and Technique, 2001AbstractThe lymphatic system serves as the primary route for the metastasis of many cancers and the extent of lymph node involvement is the most important indicator of tumor aggressiveness. Despite the apparent importance of the lymphatic vessels for tumor dissemination, it has remained unclear whether activation of lymphatic endothelial cells may ...
Mihaela Skobe, Melody A. Swartz
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