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Molecular mechanisms and imaging of lymphatic metastasis [PDF]

open access: yesExperimental Cell Research, 2013
In many types of cancer, tumors metastasize through the lymphatic system to draining lymph nodes. These sentinel lymph nodes have gained increased attention as a prognostic indicator for the severity of the disease, leading to the sentinel lymph node mapping and biopsy procedure to be accepted as standard-of-care for breast cancer and melanoma. However,
Proulx ST, Detmar M
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Lymphatic metastasis with childhood rhabdomyosarcoma

Cancer, 1977
Clinico-pathologic reviews of series of children with rhabdomyosarcoma have yielded conflicting information regarding frequency of lymphatic spread of this disease. The 264 eligible entries in the Intergroup Rhabdomyosarcoma Study (from November 1972 to September 1975) have been categorized by a prospective staging system and pre-treatment ...
W, Lawrence, D M, Hays, T E, Moon
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Lymphatic metastasis and its treatment

Cancer Treatment Reviews, 1987
The treatment of lymphatic metastasis depends on an understanding of its basic biology. We are still uncertain as to how human cancer cells enter lymphatic vessels and as to what reactions if any in the draining lymph node inhibit metastasis. We are uncertain as to whether lymphatic metastasis is an indicator or a governor of rapid dissemination, and ...
I, Carr, N, Pettigrew, B, Weinerman
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Molecular Control of Lymphatic Metastasis

Annals of the New York Academy of Sciences, 2008
The metastatic spread of tumor cells is the most lethal aspect of cancer and often occurs via the lymphatic vasculature. Both experimental tumor models and human clinicopathologic data indicate that growth of lymphatic vessels (lymphangiogenesis) near solid tumors is often associated with lymph node metastasis.
Marc G, Achen, Steven A, Stacker
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Targeting Lymphatic Metastasis

Science, 2002
Oncologists have long debated the part played by the lymphatic system of cancer patients in tumor metastasis. In a Perspective, Gershenwald and Fidler discuss new findings ( Padera et al .) showing that the lymphatic vessels surrounding tumors contribute to lymphatic metastasis.
Jeffrey E. Gershenwald, Isaiah J. Fidler
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Lymphatic metastasis

CANCER AND METASTASIS REVIEW, 1983
Lymphatic metastasis is an important mechanism in the spread of human cancer. During its course, tumor cells first penetrate the basement of membrane of the epithelium, in which they arise, and then the underlying connective tissue, carried partly by hydrostatic pressure.
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Lymphatic Metastasis of NSCLC Involves Chemotaxis Effects of Lymphatic Endothelial Cells through the CCR7–CCL21 Axis Modulated by TNF-α

open access: yesGenes, 2020
Metastasis and recurrence are the main causes of lung adenocarcinoma patients’ death. Lymphatic metastasis is the main way of non-small cell lung cancer (NSCLC) metastasis.
Wang Hongzheng, Zhiyun Xu
exaly   +2 more sources

Targeted Treatment for Lymphedema and Lymphatic Metastasis

Annals of the New York Academy of Sciences, 2008
The presence of lymphatic vessels has been known for centuries, but the key players regulating the lymphatic vessel growth and function have only been discovered during the recent decade. The lymphatic vasculature is essential for maintenance of normal fluid balance and for the immune response.
Tomi, Tervala   +2 more
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Adhesion mechanisms in lymphatic metastasis

Cancer and Metastasis Review, 1991
The role of cellular adhesion in regional lymph node metastasis of solid tumors has been investigated. The data reviewed is based on studies in four different tumor models of human, rat and murine origin. An in vitro assay measuring tumor cell attachment to cryostat sections of normal peripheral lymph nodes, obtained from the species of tumor origin ...
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Lymphatic Metastasis of Neoplasms

1983
Human cancers commonly metastasize by the lymphatics to draining lymph nodes. The existence of lymphatic vessels has been known since the observations of Aselli in 1622 and the fact that cancer can spread to lymph nodes was “well-known”to Pearson in 1793 (reviewed by Mayerson, 1969; Onuigbo, 1972).
Ian Carr, Jean Carr
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