Results 71 to 80 of about 696,685 (294)

Roles of KAI1 and nm23 in lymphangiogenesis and lymph metastasis of laryngeal squamous cell carcinoma

World Journal of Surgical Oncology, 2017
Background Lymphatic metastasis contributes to the poor prognosis of laryngeal squamous cell carcinoma (LSCC). This study aimed to investigate the roles of two metastasis suppressor genes, KAI1 and nm23, in lymphangiogenesis and lymph metastasis of LSCC.
Zongzhu Zheng, Ruihua Tian, Ping Wang
doaj   +1 more source

Gene signature characteristic of elevated stromal infiltration and activation is associated with increased risk of hematogenous and lymphatic metastasis in serous ovarian cancer [PDF]

BMC Cancer, 2019
The clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an imperative role in the formation of both intraperitoneal and distant metastases.
Huiran Yue, Jieyu Wang, Ruifang Chen, Xiaoman Hou, Jun Li, Xin Lü   +5 more
openalex   +2 more sources

The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis

Clinical and Experimental Metastasis, 2021
The lymphatic system is a complicated system consisting of the lymphatic vessels and lymph nodes draining the extracellular fluid containing cellular debris, excess water and toxins to the circulatory system. The lymph nodes serve as a filter, thus, when
S. Leong, A. Pissas, Muriel Scarato, Francoise Gallon, Marie-Hélène Pissas, M. Amore, Max C. Wu, M. Faries, A. Lund   +8 more
semanticscholar   +1 more source

Clinical Significance of Lymphatic Infiltration Detected by Immunohistochemical Double Staining in Patients with Endometrial Cancer

Clinical Medicine Insights: Oncology, 2023
Background: The presence of lymph-vascular space invasion is a powerful predictor of lymph node metastasis. However, most studies do not distinguish lymph vessel invasion (LVI) and blood vessel invasion (BVI). The aim of this study was to distinguish the
Juan Xu, Xinmei Wang, Qiuyue Du, Pengpeng Qu, Caiyan Liu   +4 more
doaj   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

The role of perineural invasion in predicting survival in patients with primary operable colorectal cancer: a systematic review [PDF]

, 2017
Perineural invasion is a clear route for cancer cell spread however, the role of nerves in cancer progression is relatively unknown. Recent work would suggest that nerves can actively infiltrate the tumour microenvironment and stimulate cancer cell ...
Going, James, Horgan, Paul, McMillan, Donald C., Van Wyk, Hester   +3 more
core   +1 more source

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

HE4 tumor marker as a predictive factor for lymphatic metastasis in endometrial cancer

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2020
Endometrial cancer is the most common genital cancer in high‐resource countries. Treatment is essentially surgical, but the role of lymphadenectomy in the treatment of low‐stage and low‐grade tumors has not been defined.
A. Espiau Romera, Tatiana Cuesta Guardiola, Marta Benito Vielba, Carlos De Bonrostro Torralba, P. C. Coronado Martín, Laura Baquedano Mainar   +5 more
semanticscholar   +1 more source

Lymph Node Gross Tumor Volume Detection in Oncology Imaging via Relationship Learning Using Graph Neural Network [PDF]

arXiv, 2020
Determining the spread of GTV$_{LN}$ is essential in defining the respective resection or irradiating regions for the downstream workflows of surgical resection and radiotherapy for many cancers. Different from the more common enlarged lymph node (LN), GTV$_{LN}$ also includes smaller ones if associated with high positron emission tomography signals ...
arxiv  

Hyaluronan-CD44 interaction promotes microRNA signaling and RhoGTPase activation leading to tumor progression. [PDF]

, 2012
A hallmark of all solid tumor malignancies is the ability to invade the surrounding tissue and/or metastasize to distant sites. Tumors cells have altered signaling pathways which that to cytoskeleton activation and migration.
Bourguignon, Lilly YW
core   +1 more source