Results 81 to 90 of about 696,685 (294)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis?

Oncogenesis, 2021
Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date.
Sini Karinen, Krista Juurikka, Roosa Hujanen, Wafa Wahbi, Elin Hadler-Olsen, Gunbjørg Svineng, Kari K. Eklund, Tuula Salo, Pirjo Åström, Abdelhakim Salem   +9 more
doaj   +1 more source

Novel application assigned to toluquinol: inhibition of lymphangiogenesis by interfering with VEGF-C/VEGFR-3 signalling pathway [PDF]

, 2016
BACKGROUND AND PURPOSE Lymphangiogenesis is an important biological process associated with the pathogenesis of several diseases, including metastatic dissemination, graft rejection, lymphoedema and other inflammatory disorders.
Blacher, S., García-Caballero, Melissa, Medina, Miguel Ángel, Nöel, Agnes, Pauper, J., Quesada, Ana R.   +5 more
core  

Application of Sentinel Lymph Node Biopsy in Cutaneous Basosquamous Carcinoma [PDF]

, 2011
Basosquamous carcinoma of the skin is a relatively rare cutaneous neoplasm that has significant metastatic potential and a metastatic rate greater than that of basal cell and squamous cell carcinoma.
Alam, Aleksandar Jankovic, Anadolu-Brasie, Bowman, Costantino, Dimitrije Jankovic, Doubrovsky, Irena Jankovic, Ivan Ilic, Ivana Binic, Lee, Martin, Milan Visnjic, Predrag Kovacevic, Ross, von Domarus   +15 more
core   +2 more sources

A novel lymphatic pattern promotes metastasis of cervical cancer in a hypoxic tumour-associated macrophage-dependent manner

Angiogenesis, 2021
Lymphatic remodelling in the hypoxic tumour microenvironment (TME) is critically involved in the metastasis of cervical squamous cell carcinoma (CSCC); however, its underlying mechanisms remain unclear. Here, we uncovered a novel lymphatic pattern in the
Xiaojing Chen, Wenfei Wei, Zici Wang, Ni-sha Wang, Chu-Hong Guo, Chenfei Zhou, Luojiao Liang, Shaoping Wu, L. Liang, W. Wang   +9 more
semanticscholar   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Aerosolization of nanotherapeutics as a newly emerging treatment regimen for peritoneal carcinomatosis

, 2019
Recent advances in locoregional chemotherapy have opened the door to new approaches for the clinical management of peritoneal carcinomatosis (PC) by facilitating the delivery of anti-neoplastic agents directly to the tumor site, while mitigating adverse ...
Ceelen, Wim, De Smedt, Stefaan, Remaut, Katrien, Shariati, Molood, Willaert, Wouter   +4 more
core   +1 more source

Colon cancer cell-derived 12(S)-HETE induces the retraction of cancer-associated fibroblast via MLC2, RHO/ROCK and Ca2+ signalling [PDF]

, 2016
Retraction of mesenchymal stromal cells supports the invasion of colorectal cancer cells (CRC) into the adjacent compartment. CRC-secreted 12(S)-HETE enhances the retraction of cancer-associated fibroblasts (CAFs) and therefore, 12(S)-HETE may enforce ...
Bago-Horvath, Zsuzsanna, Brendel, Konstantin Alexander, Brenner, Stefan, De Wever, Olivier, Dolznig, Helmut, Eichsteininger, Julia, Giessrigl, Benedikt, Holzner, Silvio, Huttary, Nicole, Jäger, Walter, Koperek, Oskar, Krenn, Liselotte, Krieger, Sigurd, Krupitza, Georg, Mader, Robert M, Marian, Brigitte, Milovanovic, Daniela, Nguyen, Chi Huu, Schachner, Helga, Schmidt, Wolfgang M, Senfter, Daniel, Stadler, Mira, Stadler, Serena   +22 more
core   +1 more source

Lymphatic Metastasis of NSCLC Involves Chemotaxis Effects of Lymphatic Endothelial Cells through the CCR7–CCL21 Axis Modulated by TNF-α

Genes, 2020
Metastasis and recurrence are the main causes of lung adenocarcinoma patients’ death. Lymphatic metastasis is the main way of non-small cell lung cancer (NSCLC) metastasis.
Shuai Zhang, Hongzheng Wang, Zhi-yun Xu, Yongkang Bai, Lin Xu   +4 more
semanticscholar   +1 more source

Unraveling the metastasis‐preventing effect of miR‐200c in vitro and in vivo

Molecular Oncology, Volume 19, Issue 4, Page 1029-1053, April 2025.
Advanced tumors and ineffective cancer treatments can lead to metastases in distant organs. The sole expression of microRNA 200c (miR‐200c) in breast cancer cells is shown to significantly reduce metastasis formation in xenograft mouse models. Various in vitro analyses revealed impeded migratory behavior, upon miR‐200c expression, as one prerequisite ...
Bianca Köhler, Emily Brieger, Tom Brandstätter, Elisa Hörterer, Ulrich Wilk, Jana Pöhmerer, Anna Jötten, Philipp Paulitschke, Chase P. Broedersz, Stefan Zahler, Joachim O. Rädler, Ernst Wagner, Andreas Roidl   +12 more
wiley   +1 more source