Results 101 to 110 of about 923,689 (313)
Engineering CAR‐T Therapeutics for Enhanced Solid Tumor Targeting
Advanced Materials, EarlyView.CART cell therapy has proven effective for blood cancers but struggles with solid tumors due to diverse antigens and complex environments. Recent efforts focus on improving CAR design and validation platforms. Advances in protein engineering, machine learning, and organoid systems aim to enhance CAR‐T therapy against solid tumors.
Danqing Zhu +4 more
wiley +1 more source
STAR Protocols, 2023 Summary: Here we detail a protocol for the isolation and processing of lymphatic enriched tissue of mouse models for the purpose of immunostaining and quantification of lymphatic valves, vessel length, and vessel diameter.
Richa Banerjee, Luz A. Knauer, Ying Yang
doaj
Network Scale Modeling of Lymph Transport and Its Effective Pumping Parameters. [PDF]
PLoS ONE, 2016 The lymphatic system is an open-ended network of vessels that run in parallel to the blood circulation system. These vessels are present in almost all of the tissues of the body to remove excess fluid.
Samira Jamalian +3 more
doaj +1 more source
An improved model of an actively contracting lymphatic vessel composed of several lymphangions: pumping characteristics [PDF]
arXiv, 2015 Using essentially our 2011 numerical model of a multi-lymphangion segment of a collecting lymphatic vessel, but augmented by inclusion of a refractory period and definition of a mid lymphangion pressure, we explore the effect of several parameters on the form of pump function curves.
arxiv
Hierarchical Deep Network with Uncertainty-aware Semi-supervised Learning for Vessel Segmentation [PDF]
arXiv, 2021 The analysis of organ vessels is essential for computer-aided diagnosis and surgical planning. But it is not a easy task since the fine-detailed connected regions of organ vessel bring a lot of ambiguity in vessel segmentation and sub-type recognition, especially for the low-contrast capillary regions.
arxiv
Lymph flow regulates collecting lymphatic vessel maturation in vivo.
Journal of Clinical Investigation, 2015 Fluid shear forces have established roles in blood vascular development and function, but whether such forces similarly influence the low-flow lymphatic system is unknown.
D. T. Sweet +8 more
semanticscholar +1 more source
Off‐The‐Shelf Multivalent Nanoconjugate Cancer Vaccine Rescues Host Immune Response against Melanoma
Advanced Materials, EarlyView.A star‐shaped cross‐linked polyglutamate (StCl) nanocarrier delivers melanoma‐associated peptide antigens via redox‐responsive linkers, inducing lymph node‐targeted antigen presentation. The nanoconjugate activates dendritic cells, promotes effector T‐cell responses, and enables tumor regression even in humanized patient‐derived preclinical models ...
Liane IF Moura +19 more
wiley +1 more source
Regulation of Lymphatic Function in Obesity
Frontiers in Physiology, 2020 The lymphatic system has many functions, including macromolecules transport, fat absorption, regulation and modulation of adaptive immune responses, clearance of inflammatory cytokines, and cholesterol metabolism.
Raghu P. Kataru +5 more
doaj +1 more source
Anatomy of the vertebral column lymphatic network in mice [PDF]
arXiv, 2019 Cranial lymphatic vessels (LVs) are involved in transport of fluids, macromolecules and CNS immune responses. Little information about spinal LVs is available, because these delicate structures are embedded within vertebral tissues and difficult to visualize using traditional histology. Here we reveal an extended vertebral column LV network using three-
arxiv
Blood, 2016 Aside from the established role for platelets in regulating hemostasis and thrombosis, recent research has revealed a discrete role for platelets in the separation of the blood and lymphatic vascular systems.
J. Welsh, M. Kahn, D. T. Sweet
semanticscholar +1 more source