Results 231 to 240 of about 450,414 (301)

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Lymphatic vessel network injury reduces local tumor control despite preservation of the tumor-draining lymph node. [PDF]

Sci Rep
Liebman LN, Shen Y, Buchwald ZS, Nepiyushchikh Z, Qi Z, García AJ, Dixon JB.   +6 more
europepmc   +1 more source

AI‐Driven Rational Design of Nanotherapeutics for Pancreatic Ductal Adenocarcinoma

Medicinal Research Reviews, EarlyView.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains a formidable malignancy characterized by late diagnosis, high recurrence rates, and pronounced chemoresistance. While nanoparticle‐based drug delivery systems (NDDS) offer theoretical advantages over conventional therapies, their clinical translation in PDAC has been severely limited.
Seohyun Choo, Kaeun Chae, Jueun Lee, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting

Medicinal Research Reviews, EarlyView.
ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama, Michael Overduin, Khaled H. Barakat   +2 more
wiley   +1 more source

Tumor-associated lymphatic vessel density is a postoperative prognostic biomarker of hepatobiliary cancers: a systematic review and meta-analysis. [PDF]

Front Immunol
Li J, Liang YB, Wang QB, Li YK, Chen XM, Luo WL, Lakang Y, Yang ZS, Wang Y, Li ZW, Ke Y.   +10 more
europepmc   +1 more source

Isolated Cephalic Perfusion via Aortic Occlusion for Cervicofacial Simulation: Validation of a High‐Fidelity Cadaveric Model

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective High‐fidelity simulation may improve surgical training in head and neck surgery, yet validated perfused cadaveric models remain scarce. We evaluated the face, content, and construct validity of a perfused cadaveric model using isolated cephalic perfusion for cervicofacial surgical simulation. Study Design Prospective validation study
Victor Benvegnu, Alexandre Guibert, Raphaël Lopez, Guillaume De Bonnecaze, Patrick Chaynes, Frédéric Lauwers, Elodie Chantalat, Luana Carfagna, Alice Prevost, Zoé Cavallier, Vanessa Danevoy, Quentin Festinger, Cyril Breque, Ariane Weyl, Amaury DE Barros   +14 more
wiley   +1 more source

Fibroblasts facilitate lymphatic vessel formation in transplanted heart. [PDF]

Theranostics
Gong H, Wang T, Sun X, Zhang Y, Qiu Y, Sun W, Zhang Y, Teng P, Hu Y, Hu X, Ma L, Xu Q, Zhao H.   +12 more
europepmc   +1 more source

Beyond a single ratio: an adaptable deep learning approach to analyze the prognostic value of TSP distribution in ovarian cancer

The Journal of Pathology, EarlyView.
Abstract The tumor–stroma percentage (TSP) has been proposed as a prognostic factor in ovarian cancer. When assessed manually by pathologists, the TSP can be subject to significant inter‐rater variability. Automated methods for TSP determination have recently been developed.
Daniel Firmbach, Petr Kuritcyn, Michaela Benz, Pamela L Strissel, Reiner Strick, Matthias W Beckmann, Laura Glossner, Julius Emons, Volker Bruns, Arndt Hartmann, Markus Eckstein, Christian Matek   +11 more
wiley   +1 more source

ERG Regulates Lymphatic Vessel Specification Genes and Its Deficiency Impairs Wound Healing-Associated Lymphangiogenesis. [PDF]

Arthritis Rheumatol
Yamashita T, Kaplan U, Chakraborty A, Marden G, Gritli S, Roh D, Bujor A, Trojanowski M, Ligresti G, Browning JL, Trojanowska M.   +10 more
europepmc   +1 more source

Clinical prognostic risk model optimization based on vascular density in neuroblastoma

Pediatric Investigation, EarlyView.
This study integrates lymphatic vessel density with the International Neuroblastoma Risk Group (INRG) risk classification to develop a more accurate clinical prognostic model for neuroblastoma, demonstrating superior discrimination, calibration, and clinical net benefit compared with the INRG risk classification alone.
Qiaoyin Liu, Jialin Cui, Dong Ren, Lei Yang, Xinyu Wang, Jiatong Xu, Yifan Liu, Cong Zhang, Haoyu Xu, Lejian He, Huanmin Wang, Haiyan Cheng, Guoshuang Feng, Xin Ni, Shengcai Wang, Yaqiong Jin   +15 more
wiley   +1 more source