Results 31 to 40 of about 968,485 (355)
Lymphangiogenesis and carcinoma in the uterine cervix: Joint and hierarchical models for random cluster sizes and continuous outcomes [PDF]
Annals of Applied Statistics 2015, Vol. 9, No. 4, 1932-1949, 2016 Although the lymphatic system is clearly linked to the metastasis of most human carcinomas, the mechanisms by which lymphangiogenesis occurs in response to the presence of carcinoma remain unclear. Hierarchical models are presented to investigate the properties of lymphatic vessel production in 2997 fields taken from 20 individuals with invasive ...
arxiv +1 more source
Lymphatic Vessel Network Structure and Physiology.
Comprehensive Physiology, 2018 The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body.
J. Breslin +5 more
semanticscholar +1 more source
Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
doaj +1 more source
Impaired meningeal lymphatic vessel development worsens stroke outcome
Journal of Cerebral Blood Flow and Metabolism, 2019 The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3 ...
Pavel Yanev +8 more
semanticscholar +1 more source
Microanatomical organization of hepatic venous lymphatic system in humans.
PLoS ONE, 2023 Lymphatic fluid drains from the liver via the periportal lymphatic, hepatic venous lymphatic, and superficial lymphatic systems. We performed a postmortem study to clarify the three-dimensional structure and flow dynamics of the human hepatic venous ...
Kotaro Umemura +11 more
doaj +2 more sources
Tumor-Associated Lymphatic Vessel Features and Immunomodulatory Functions
Frontiers in Immunology, 2019 The lymphatic system comprises a network of lymphoid tissues and vessels that drains the extracellular compartment of most tissues. During tumor development, lymphatic endothelial cells (LECs) substantially expand in response to VEGFR-3 engagement by ...
L. Garnier, A. Gkountidi, S. Hugues
semanticscholar +1 more source
Nature Communications, 2018 Tissue and vessel wall stiffening alters endothelial cell properties and contributes to vascular dysfunction. However, whether extracellular matrix (ECM) stiffness impacts vascular development is not known.
Maike Frye +13 more
semanticscholar +1 more source
Lymphatic Vessels and Their Surroundings: How Local Physical Factors Affect Lymph Flow
Biology, 2020 Lymphatic vessels drain and propel lymph by exploiting external forces that surrounding tissues exert upon vessel walls (extrinsic mechanism) and by using active, rhythmic contractions of lymphatic muscle cells embedded in the vessel wall of collecting ...
Eleonora Solari +3 more
doaj +1 more source
Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis
Frontiers in Bioengineering and Biotechnology, 2021 Metastasis is the primary cause of a large number of cancer-associated deaths. By portraying the precise environment of the metastasis process in vitro, the microfluidic system provides useful insights on the mechanisms underlying cancer cell migration ...
Hyeon-Yeol Cho +5 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2009 Background To investigate the role of vascular endothelial growth factors (VEGF)-C/D and their receptor Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma.
Zhang Renhua +3 more
doaj +1 more source