Morphological changes in lymphatic vessel endothelial cells.
, 2013 Scanning electron microscopy (SEM) findings. (a) Lymphatic vessel endothelial cells protruding into the lymphatic lumen in the normal type. Bar = 10 µm. (b) Lymphangiectasia at its early stages.
Takeshi Todokoro (314536) +13 more
core +1 more source
In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging [PDF]
, 2016 Techniques to image lymphatic vessel function in either animal models or in the clinic are limited. In particular, imaging methods that can provide robust outcome measures for collecting lymphatic vessel function are sorely needed.
Luciani, Paola +16 more
core +2 more sources
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis
Frontiers in Bioengineering and Biotechnology, 2021 Metastasis is the primary cause of a large number of cancer-associated deaths. By portraying the precise environment of the metastasis process in vitro, the microfluidic system provides useful insights on the mechanisms underlying cancer cell migration ...
Hyeon-Yeol Cho +5 more
doaj +1 more source
Whole Slide Quantification of Stromal Lymphatic Vessel Distribution and Peritumoral Lymphatic Vessel Density in Early Invasive Cervical Cancer: A Method Description [PDF]
, 2011 peer reviewedPeritumoral Lymphatic Vessel Density (LVD) is considered to be a predictive marker for the presence of lymph node metastases in cervical cancer.
Foidart, Jean Michel +28 more
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Three-Dimensional In Vitro Lymphangiogenesis Model in Tumor Microenvironment
Frontiers in Bioengineering and Biotechnology, 2021 Lymphangiogenesis is a stage of new lymphatic vessel formation in development and pathology, such as inflammation and tumor metastasis. Physiologically relevant models of lymphatic vessels have been in demand because studies on lymphatic vessels are ...
Youngkyu Cho +9 more
doaj +1 more source
Minimally-invasive method for the point-of-care quantification of lymphatic vessel function [PDF]
, 2019 Current clinical methods for the evaluation of lymphatic vessel function, crucial for early diagnosis and evaluation of treatment-response of several pathological conditions, in particular of post-surgical lymphedema, are based on complex and mainly ...
Vasileva, Tsvetina +25 more
core +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density [PDF]
, 2014 Macrophages regulate lymphatic vasculature development; however, the molecular mechanisms regulating their recruitment to developing, and adult, lymphatic vascular sites are not known.
Lee, Kit M +21 more
core +2 more sources