Results 41 to 50 of about 1,203,096 (351)

New insights about the lymphatic vasculature in cardiovascular diseases [version 1; peer review: 2 approved]

F1000Research, 2019
The heart contains a complex network of blood and lymphatic vessels. The coronary blood vessels provide the cardiac tissue with oxygen and nutrients and have been the major focus of research for the past few decades.
Xiaolei Liu, Guillermo Oliver
doaj   +1 more source

Endothelial-specific depletion of TGF-β signaling affects lymphatic function

Inflammation and Regeneration, 2021
Background Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis.
Kunpei Fukasawa, Kako Hanada, Kei Ichikawa, Masanori Hirashima, Takahiro Takagi, Susumu Itoh, Testuro Watabe, Fumiko Itoh   +7 more
doaj   +1 more source

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling

bioRxiv, 2020
During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to circulating lymph, as they are not lumenized. In contrast, LECs that trail
Xin Geng, K. Yanagida, R. Akwii, Dongwon Choi, Li-Jun Chen, Y. Ho, B. Cha, Md Riaj Mahamud, Karen Berman de Ruiz, H. Ichise, Hong Chen, Joshua D. Wythe, Constantinos M Mikelis, T. Hla, R. Srinivasan   +14 more
semanticscholar   +1 more source

Lymphangiogenesis in breast carcinoma is present but insufficient for metastatic spread [PDF]

, 2014
Introduction: The lymphatic vasculature is an important route for the metastatic spread of human cancer. However, the extent to which this depends on lymphangiogenesis or on invasion of existing lymph vessels remains controversial. The goal of this study
Babić, Mirsad, Dorić, Mirsad, Hukić, Ajna, Kuskunović-Vlahovljak, Suada, Lazović-Salčin, Edina, Radović, Svjetlana   +5 more
core   +3 more sources

Lymphatic Vessels and Their Surroundings: How Local Physical Factors Affect Lymph Flow

Biology, 2020
Simple Summary Lymphatic vessels are responsible for the drainage of liquids, solutes, and cells from interstitial spaces and serosal cavities. Their task is fundamental in order to avoid fluid accumulation leading to tissue swelling and edema.
E. Solari, C. Marcozzi, D. Negrini, A. Moriondo   +3 more
semanticscholar   +1 more source

Lymphatic Vessels in Tumor Dissemination versus Immunotherapy

Cancer Research, 2020
During the growth of various cancers, primary tumors can escape antitumor immune responses of their host and eventually disseminate into distant organs. Peritumoral lymphatic vessels connect the primary tumor to lymph nodes, facilitating tumor entry into
Kari Vaahtomeri, K. Alitalo
semanticscholar   +1 more source

Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors [PDF]

, 2005
The study of lymphatic vessels and lymphatic tumors has been hampered with difficulty due to the overlapping morphological features between blood and lymphatic endothelial cells, as well as to the lack of specific lymphatic endothelial markers.
Adhemar Longatto Filho, Alitalo, Belecky-Adams, Boshoff, Breiteneder-Geleff, Carmeliet, Carreira, Fletcher, Folpe, Jackson, Jorge S. Reis-Filho, José M. Lopes, Kahn, Lohela, Makinen, Oliver, Oliver, Oliver, Padera, Papoutsi, Papper, Partanen, Paula Silva, Petrova, Rafii, Reis-Filho, Rodriguez-Niedenfuhr, Rui M. Reis, Sauter, Stanislav Tomarev, Tomarev, Weiss, Wigle, Wigle, Wilting, Witmer, Xu   +36 more
core   +1 more source

Differential regulation of lymphatic junctional morphology and the potential effects on cardiovascular diseases

Frontiers in Physiology, 2023
The lymphatic vasculature provides an essential route to drain fluid, macromolecules, and immune cells from the interstitium as lymph, returning it to the bloodstream where the thoracic duct meets the subclavian vein.
Amanda M. Peluzzo, Meriem Bkhache, Long Nguyen Hoang Do, Michael V. Autieri, Xiaolei Liu   +4 more
doaj   +1 more source

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

Nature Communications, 2017
Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid projections from the subarachnoid space to the dural venous sinuses. However, a lymphatic component to CSF outflow has long been known.
Qiaoli Ma, B. Ineichen, M. Detmar, Steven T. Proulx   +3 more
semanticscholar   +1 more source

Human Tumor‐Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Cells

Advanced Healthcare Materials, 2020
Breast tumor progression is a complex process involving intricate crosstalk between the primary tumor and its microenvironment. In the context of breast tumor‐lymphatic interactions, it is unclear how breast cancer cells alter the gene expression of ...
J. Ayuso, Max M Gong, M. Skala, P. Harari, D. Beebe   +4 more
semanticscholar   +1 more source