Results 41 to 50 of about 85,392 (192)

NO‐Driven Janus Nanomotor Enhances T‐Cell Infiltration by Reconstructing Tumor‐Associated Blood and Lymphatic Vessels

open access: yesAdvanced Science, EarlyView.
NO‐driven hollow gold Janus nanomotors (HAM) are engineered to improve tumor blood vessel normalization throughout the entire tumor region to enhance T‐cell intratumoral infiltration, and generate and capture whole‐tumor antigens as an in situ cancer vaccine to enhance T‐cell activation, therefore enhancing the antitumor immune response.
Qingping Ma   +15 more
wiley   +1 more source

Randomized preclinical study of machine perfusion in vascularized composite allografts

open access: yesBJS (British Journal of Surgery), EarlyView., 2020
This study was designed to identify the optimum machine perfusion parameters for preservation of limbs before transplantation, and determine whether this was better than cold storage. Normothermic machine perfusion at a pressure of 70 mmHg (NMP‐70) provided superior preservation to cold storage after transplantation.
K. R. Amin   +7 more
wiley   +1 more source

Designer Solid Self‐Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity

open access: yesAdvanced Science, EarlyView.
A solid self‐emulsifying (SSE) platform is loaded with peptide antigens and CpG to form the SSE vaccine. An ApoE‐enriched corona promotes dendritic cell internalization, enabling antigen presentation and T cell activation. Squalene from the SSE also sensitizes T cells by promoting lipid raft formation.
Xueying Shen   +8 more
wiley   +1 more source

Mild Photothermal Bimetallic Mesoporous Nanozyme Triggers Immunogenic Cell Death and Immune Contexture Remodeling for Precision Hepatocellular Carcinoma Treatment

open access: yesAdvanced Science, EarlyView.
In this study, a Pt/Co BNzyme with peroxidase/GPx‐like activity is developed, increasing oxidative stress by generating ROS and depleting GSH to induce ICD. The mild PTT effect enhanced its enzymatic activity. The Pt/Co BNzyme remodeled the TME, promoting DC maturation.
Yanbing Huang   +9 more
wiley   +1 more source

Integrative Multi‐Omics Analysis Uncovers Immunological Phenotypes Predictive of Combinatorial Immunotherapy Response in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Current understanding of gastric cancer immunity remains inadequate, leading to suboptimal immunotherapy outcomes. This study introduces a novel tumor immune microenvironment classification system (Inflamed, Desert, and Excluded), advancing traditional histopathological or molecular subtyping toward a functional immunological framework.
Jianchao Wang   +14 more
wiley   +1 more source

Identifying Key Questions and Challenges in Microchimerism Biology

open access: yesAdvanced Science, EarlyView.
This study identifies key unanswered questions about microchimerism, the presence of cells from one individual living in another. Experts highlight how these cells may affect health, pregnancy, and disease. This study outlines research priorities and challenges in detecting and studying these rare microchimeric cells, aiming to guide future discoveries
Kristine J. Chua   +31 more
wiley   +1 more source

An important role of lymphatic vessel activation in limiting acute inflammation [PDF]

open access: bronze, 2011
Reto Huggenberger   +8 more
openalex   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

open access: yesAdvanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan   +5 more
wiley   +1 more source

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