Results 41 to 50 of about 1,001,687 (372)
bioRxiv, 2020 During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to circulating lymph, as they are not lumenized. In contrast, LECs that trail
Xin Geng +14 more
semanticscholar +1 more source
Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Frontiers in Cell and Developmental Biology, 2023 Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs.
Lorenzo M. Fernandes +7 more
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Lymphatic Vessels in Tumor Dissemination versus Immunotherapy
Cancer Research, 2020 During the growth of various cancers, primary tumors can escape antitumor immune responses of their host and eventually disseminate into distant organs. Peritumoral lymphatic vessels connect the primary tumor to lymph nodes, facilitating tumor entry into
Kari Vaahtomeri, K. Alitalo
semanticscholar +1 more source
Endothelial-specific depletion of TGF-β signaling affects lymphatic function
Inflammation and Regeneration, 2021 Background Transforming growth factor (TGF)-β is a multifunctional cytokine involved in cell differentiation, cell proliferation, and tissue homeostasis.
Kunpei Fukasawa +7 more
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Lymphatic Vessels and Their Surroundings: How Local Physical Factors Affect Lymph Flow
Biology, 2020 Simple Summary Lymphatic vessels are responsible for the drainage of liquids, solutes, and cells from interstitial spaces and serosal cavities. Their task is fundamental in order to avoid fluid accumulation leading to tissue swelling and edema.
E. Solari +3 more
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Mechanical forces in lymphatic vessel development: Focus on transcriptional regulation
Frontiers in Physiology, 2022 The lymphatic system is crucial for the maintenance of interstitial fluid and protein homeostasis. It has important roles in collecting excess plasma and interstitial fluid leaked from blood vessels, lipid absorption and transportation in the digestive ...
Naoto Ujiie, Tsutomu Kume
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Advanced Healthcare Materials, 2020 Breast tumor progression is a complex process involving intricate crosstalk between the primary tumor and its microenvironment. In the context of breast tumor‐lymphatic interactions, it is unclear how breast cancer cells alter the gene expression of ...
J. Ayuso +4 more
semanticscholar +1 more source
Lymphangiogenesis and carcinoma in the uterine cervix: Joint and hierarchical models for random cluster sizes and continuous outcomes [PDF]
Annals of Applied Statistics 2015, Vol. 9, No. 4, 1932-1949, 2016 Although the lymphatic system is clearly linked to the metastasis of most human carcinomas, the mechanisms by which lymphangiogenesis occurs in response to the presence of carcinoma remain unclear. Hierarchical models are presented to investigate the properties of lymphatic vessel production in 2997 fields taken from 20 individuals with invasive ...
arxiv +1 more source
Chronic high-fat diet impairs collecting lymphatic vessel function in mice.
PLoS ONE, 2014 Lymphatic vessels play an essential role in intestinal lipid uptake, and impairment of lymphatic vessel function leads to enhanced adipose tissue accumulation in patients with lymphedema and in genetic mouse models of lymphatic dysfunction.
Katrin S Blum +7 more
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F1000Research, 2019 The heart contains a complex network of blood and lymphatic vessels. The coronary blood vessels provide the cardiac tissue with oxygen and nutrients and have been the major focus of research for the past few decades.
Xiaolei Liu, Guillermo Oliver
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