Results 61 to 70 of about 431,164 (300)

Spatial Control of Light‐Responsive Proteins and Optogenetics Within Hydrogels via Volumetric Bioprinting

open access: yesAdvanced Materials, EarlyView.
Spatiotemporal control over cell behavior within bioprinted constructs remains a key challenge in biofabrication. Volumetric bioprinting using multi‐wavelength light sources permits to activate light‐sensitive intracellular proteins as well as optogenetic gene and protein expression circuits in bioprinted cells, in addition to enabling fast printing of
Davide Ribezzi   +14 more
wiley   +1 more source

Nuclear Pore Mechanotransduction in Oncology: A Structural Axis of Vulnerability for Targeted Intervention

open access: yesAdvanced Materials, EarlyView.
Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello   +5 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

open access: yesAdvanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang   +5 more
wiley   +1 more source

Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities.

open access: yesPLoS ONE, 2021
Lymphatic vessels are indispensable for tissue fluid homeostasis, transport of solutes and dietary lipids and immune cell trafficking. In contrast to blood vessels, which are easily visible by their erythrocyte cargo, lymphatic vessels are not readily ...
Esther Redder   +5 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

open access: yesAdvanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez   +16 more
wiley   +1 more source

Modelling the fluid drainage through primary lymphatic valves

open access: yes, 2013
This study investigates the fluid flow through tissues where lymphatic drainage occurs. Lymphatic drainage relies on two unidirectional valve systems, primary and secondary.
Heppell, Charles
core   +1 more source

Impaired meningeal lymphatic drainage in Listeria monocytogenes infection

open access: yesFrontiers in Immunology
Previous studies have demonstrated an association between lymphatic vessels and diseases caused by bacterial infections. Listeria monocytogenes (LM) bacterial infection can affect multiple organs, including the intestine, brain, liver and spleen, which ...
Jian Feng   +16 more
doaj   +1 more source

Transcriptional profiling of breast cancer-associated lymphatic vessels reveals VCAM-1 as regulator of lymphatic invasion and permeability. [PDF]

open access: yes, 2019
Tumor-associated lymphangiogenesis and lymphatic invasion of tumor cells correlate with poor outcome in many tumor types, including breast cancer. Various explanations for this correlation have been suggested in the past, including the promotion of ...
Lothar C. Dieterich   +23 more
core   +2 more sources

Pediatric Mediastinal Gray Zone Lymphoma With Germline TET2 Heterozygous Variant

open access: yes
Pediatric Blood &Cancer, EarlyView.
Matthew R. Schuelke   +9 more
wiley   +1 more source

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