Results 71 to 80 of about 145,040 (309)

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Application of percutaneous lymphatic contrast-enhanced ultrasound in lymphovenous anastomosis microsurgery.

PLoS ONE
ObjectiveThis study evaluated percutaneous lymphatic contrast-enhanced ultrasound (CEUS) for preoperative localization in preparation for lymphovenous anastomosis (LVA) microsurgery.MethodsFourteen healthy volunteers and 14 patients with lower limb ...
Jing Wang, Ming Xing Hu, Min Lu, Xu Li
doaj   +1 more source

Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]

, 2010
Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Becker, Bernhard F., Bruegger, Dirk, Chappell, Daniel, Conzen, Peter, Jacob, Matthias, Kaczmarek, Ingo, Rehm, Markus, Stoeckelhuber, Mechthild, Welsch, Ulrich   +8 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Histological and biochemical changes in lymphatic vessels after skeletal muscle injury induced by lengthening contraction in male mice

Physiological Reports
Lymphatic vessels are actively involved in the recovery process of inflamed tissues. However, the changes in intramuscular lymphatic vessels during inflammation caused by skeletal muscle injury remain unclear.
Yuma Tamura, Takafumi Kawashima, Rui‐Cheng Ji, Nobuhide Agata, Yuta Itoh, Keisuke Kawakami   +5 more
doaj   +1 more source

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature.

PLoS ONE, 2013
Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. However, the role VEGFR2 serves in the development of the lymphatic vascular system
Michael T Dellinger, Stryder M Meadows, Katherine Wynne, Ondine Cleaver, Rolf A Brekken   +4 more
doaj   +1 more source

Dynamics of lymphatic regeneration and flow patterns after lymph node dissection [PDF]

, 2018
Knowledge about the mechanisms of regeneration of the lymphatic vasculature after surgical trauma is essential for the development of strategies for the prevention and therapy of lymphedema.
Blum, Katrin, Detmar, Michael, Leroux, Jean-Christophe, Luciani, Paola, Proulx, Steven   +4 more
core  

Antigen-presenting cells and antigen presentation in tertiary lymphoid organs [PDF]

, 2016
Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures.
Bedaj, Marija, Benson, Robert A., Hughes, Catherine E., Maffia, Pasquale   +3 more
core   +1 more source

Pathophysiology of aged lymphatic vessels

Aging, 2019
Lymphatic vessels maintain body homeostasis by recirculation of fluid and cells. Cell senescence induces lymphatic dysfunction. Impaired contractile function is caused by low muscle cell investiture and decrease of nitric oxide in aged lymphatic collectors, leading to poor drainage of lymph.
Shang, Tongyao, Liang, Jiangjiu, Kapron, Carolyn M., Liu, Ju   +3 more
openaire   +2 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source