Results 51 to 60 of about 1,092,661 (368)

S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling

bioRxiv, 2020
During the growth of lymphatic vessels (lymphangiogenesis), lymphatic endothelial cells (LECs) at the growing front sprout by forming filopodia. Those tip cells are not exposed to circulating lymph, as they are not lumenized. In contrast, LECs that trail
Xin Geng, K. Yanagida, R. Akwii, Dongwon Choi, Li-Jun Chen, Y. Ho, B. Cha, Md Riaj Mahamud, Karen Berman de Ruiz, H. Ichise, Hong Chen, Joshua D. Wythe, Constantinos M Mikelis, T. Hla, R. Srinivasan   +14 more
semanticscholar   +1 more source

Leukocyte Trafficking in Lymphatic Vessels. [PDF]

Cold Spring Harb Perspect Med, 2022
To ensure proper immune function, most leukocytes constantly move within tissues or between them using the blood and lymphatic vessels as transport routes. While afferent lymphatic vessels transfer leukocytes from peripheral tissues to draining lymph nodes (dLNs), efferent lymphatics return lymphocytes from LNs back into the blood vascular circulation.
Bauer A, Tatliadim H, Halin C.
europepmc   +3 more sources

Vascular endothelial growth factor receptor-2 promotes the development of the lymphatic vasculature. [PDF]

PLoS ONE, 2013
Vascular endothelial growth factor receptor 2 (VEGFR2) is highly expressed by lymphatic endothelial cells and has been shown to stimulate lymphangiogenesis in adult mice. However, the role VEGFR2 serves in the development of the lymphatic vascular system
Michael T Dellinger, Stryder M Meadows, Katherine Wynne, Ondine Cleaver, Rolf A Brekken   +4 more
doaj   +1 more source

Outflow of cerebrospinal fluid is predominantly through lymphatic vessels and is reduced in aged mice

Nature Communications, 2017
Cerebrospinal fluid (CSF) has been commonly accepted to drain through arachnoid projections from the subarachnoid space to the dural venous sinuses. However, a lymphatic component to CSF outflow has long been known.
Qiaoli Ma, B. Ineichen, M. Detmar, Steven T. Proulx   +3 more
semanticscholar   +1 more source

Differential regulation of lymphatic junctional morphology and the potential effects on cardiovascular diseases

Frontiers in Physiology, 2023
The lymphatic vasculature provides an essential route to drain fluid, macromolecules, and immune cells from the interstitium as lymph, returning it to the bloodstream where the thoracic duct meets the subclavian vein.
Amanda M. Peluzzo, Meriem Bkhache, Long Nguyen Hoang Do, Michael V. Autieri, Xiaolei Liu   +4 more
doaj   +1 more source

Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors [PDF]

, 2005
The study of lymphatic vessels and lymphatic tumors has been hampered with difficulty due to the overlapping morphological features between blood and lymphatic endothelial cells, as well as to the lack of specific lymphatic endothelial markers.
Adhemar Longatto Filho, Alitalo, Belecky-Adams, Boshoff, Breiteneder-Geleff, Carmeliet, Carreira, Fletcher, Folpe, Jackson, Jorge S. Reis-Filho, José M. Lopes, Kahn, Lohela, Makinen, Oliver, Oliver, Oliver, Padera, Papoutsi, Papper, Partanen, Paula Silva, Petrova, Rafii, Reis-Filho, Rodriguez-Niedenfuhr, Rui M. Reis, Sauter, Stanislav Tomarev, Tomarev, Weiss, Wigle, Wigle, Wilting, Witmer, Xu   +36 more
core   +1 more source

Human Tumor‐Lymphatic Microfluidic Model Reveals Differential Conditioning of Lymphatic Vessels by Breast Cancer Cells

Advanced Healthcare Materials, 2020
Breast tumor progression is a complex process involving intricate crosstalk between the primary tumor and its microenvironment. In the context of breast tumor‐lymphatic interactions, it is unclear how breast cancer cells alter the gene expression of ...
J. Ayuso, Max M Gong, M. Skala, P. Harari, D. Beebe   +4 more
semanticscholar   +1 more source

Lymphatic Vasculature in Energy Homeostasis and Obesity

Frontiers in Physiology, 2020
Obesity is a leading cause of cardiovascular diseases and cancer. Body mass is regulated by the balance between energy uptake and energy expenditure. The etiology of obesity is determined by multiple factors including genetics, nutrient absorption, and ...
Yen-Chun Ho, R. Sathish Srinivasan, R. Sathish Srinivasan   +2 more
doaj   +1 more source

Lymphatic vasculature in the central nervous system

Frontiers in Cell and Developmental Biology, 2023
The central nervous system (CNS) is considered as an immune privilege organ, based on experiments in the mid 20th century showing that the brain fails to mount an efficient immune response against an allogeneic graft.
Sara González-Hernández, Yoh-suke Mukouyama   +1 more
doaj   +1 more source

Lymphatic Vessels in Chronic Rhinosinusitis. [PDF]

J Inflamm Res
The purpose of this study was to analyze the nasal lymphatic system in order to uncover novel factors that might be involved in pathogenesis of chronic rhinosinusitis (CRS) with (CRSwNP) and without nasal polyps (CRSsNP).Lymphatic vessels (LVs) and macrophages were localized and counted in the inferior and middle turbinate, the uncinate process and the
Pesold VV, Wendler O, Gröhn F, Mueller SK.   +3 more
europepmc   +5 more sources