Results 51 to 60 of about 147,823 (327)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Lymphatic marker podoplanin/D2-40 in human advanced cirrhotic liver- Re-evaluations of microlymphatic abnormalities

BMC Gastroenterology, 2010
Background From the morphological appearance, it was impossible to distinguish terminal portal venules from small lymphatic vessels in the portal tract even using histochemical microscopic techniques.
Yoshimura Kazunori, Tanabe Minoru, Kawachi Shigeyuki, Kaneko Fumihiko, Oda Masaya, Yokomori Hiroaki, Kitagawa Yuko, Hibi Toshifumi   +7 more
doaj   +1 more source

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. [PDF]

, 2015
The small intestine is a dynamic and complex organ that is characterized by constant epithelium turnover and crosstalk among various cell types and the microbiota.
Barker, Benedito, Cansaran Saygili Demir, Christophe Cisarovsky, Freddy Radtke, Humphrey, Jeremiah Bernier-Latmani, Jurisic, Kamba, Malanchi, Marine Bruand, Muriel Jaquet, Nowotschin, Olivier Dormond, Prewett, Rui Benedito, Sanjiv A. Luther, Shutter, Simone Ragusa, Srinivas, Stefanie Siegert, Suzel Davanture, Tatiana V. Petrova, Womack   +23 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Lymphatic vessel density and VEGF-C expression are significantly different among benign and malignant thyroid lesions [PDF]

, 2010
Thyroid cancer is the most frequent endocrine neoplasia worldwide. The route for metastasis and loco-regional invasion preferentially occurs by lymphatic vessels.
A Longatto-Filho, A Longatto-Filho, Adhemar Longatto-Filho, Alda Wakamatsu, AM Byrne, BHH Lang, Eduardo Anselmo Garcia, GNL Torre, H Kurahara, HJ Kahn, I Auwera Van der, J Afonso, JS Reis-Fillho, K Alitalo, Kleber Simões, L Jussila, M Fassnacht, MJ Karkkainen, MJ Schlumberger, N Weidner, NJ Beasley, P Bono, RJ Roskoski, Roberto Souza Camargo, Rodrigo Albergaria Ressio, RS Camargo, SA Stacker, SE Duff, T Kondo, TA Giorgadze, TP Padera, V Schacht, Venâncio Avancini Ferreira Alves, Y Yamazaki, Z Gombos   +34 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The role of lymphatics in renal inflammation [PDF]

, 2017
Progressive renal diseases are characterized by tubulointerstitial inflammatory cell recruitment, tubular atrophy and fibrosis. Various aspects of the recruitment of leukocytes have been extensively studied, but the exit routes (i.e.
Bonani, Marco, Seeger, Harald, Segerer, Stephan   +2 more
core  

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. [PDF]

, 2015
The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Adams, R.H., Agalarov, Y., Bibb, J.A., Demir, C.S., Hager, B., Kiefer, F., Liebl, J., Miura, N., Moser, M., Petrova, T.V., Vollmar, A.M., Zahler, S., Zhang, S.   +12 more
core   +2 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Leukocyte Trafficking via Lymphatic Vessels in Atherosclerosis

Cells, 2021
In recent years, lymphatic vessels have received increasing attention and our understanding of their development and functional roles in health and diseases has greatly improved. It has become clear that lymphatic vessels are critically involved in acute
Kim Pin Yeo, Hwee Ying Lim, Veronique Angeli   +2 more
doaj   +1 more source