Results 71 to 80 of about 1,203,096 (351)

Vegfr3-tdTomato, a reporter mouse for microscopic visualization of lymphatic vessel by multiple modalities.

PLoS ONE, 2021
Lymphatic vessels are indispensable for tissue fluid homeostasis, transport of solutes and dietary lipids and immune cell trafficking. In contrast to blood vessels, which are easily visible by their erythrocyte cargo, lymphatic vessels are not readily ...
Esther Redder, Nils Kirschnick, Stefanie Bobe, René Hägerling, Nils Rouven Hansmeier, Friedemann Kiefer   +5 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Cdk5 controls lymphatic vessel development and function by phosphorylation of Foxc2. [PDF]

, 2015
The lymphatic system maintains tissue fluid balance, and dysfunction of lymphatic vessels and valves causes human lymphedema syndromes. Yet, our knowledge of the molecular mechanisms underlying lymphatic vessel development is still limited. Here, we show
Adams, R.H., Agalarov, Y., Bibb, J.A., Demir, C.S., Hager, B., Kiefer, F., Liebl, J., Miura, N., Moser, M., Petrova, T.V., Vollmar, A.M., Zahler, S., Zhang, S.   +12 more
core   +2 more sources

The Interplay Between Lymphatic Vessels and Chemokines

Frontiers in Immunology, 2019
Chemokines are a family of small protein cytokines that act as chemoattractants to migrating cells, in particular those of the immune system. They are categorized functionally as either homeostatic, constitutively produced by tissues for basal levels of ...
R. Farnsworth, T. Karnezis, Simon J Maciburko, Scott N. Mueller, S. Stacker   +4 more
semanticscholar   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Development and plasticity of meningeal lymphatic vessels

Journal of Experimental Medicine, 2017
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance.
Salli Antila, Sinem Karaman, H. Nurmi, M. Airavaara, M. Voutilainen, T. Mathivet, D. Chilov, Zhilin Li, Tapani K. Koppinen, Jun-Hee Park, Shentong Fang, Aleksanteri Aspelund, M. Saarma, A. Eichmann, Jean-Léon Thomas, K. Alitalo   +15 more
semanticscholar   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Leukocyte Trafficking via Lymphatic Vessels in Atherosclerosis

Cells, 2021
In recent years, lymphatic vessels have received increasing attention and our understanding of their development and functional roles in health and diseases has greatly improved. It has become clear that lymphatic vessels are critically involved in acute
Kim Pin Yeo, Hwee Ying Lim, Veronique Angeli   +2 more
doaj   +1 more source

A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo [PDF]

, 2012
In vivo imaging has revolutionized understanding of the spatiotemporal complexity that subserves the generation of successful effector and regulatory immune responses.
Andrea J. White, Butcher, Cardillo, Carragher, Catherine M. Rush, Celli, de Boer, Eric J. Jenkinson, Farr, Fulmer, Gianluca Grassia, Girard, Graham Anderson, Gunn, Hillebrands, Huang, Iain B. McInnes, Itano, James M. Brewer, Karen J. Bryson, Kono, Lane, Leishman, Luther, McNagny, Millington, Pasquale Maffia, Paul Garside, Proudman, Robert A. Benson, Schneider, Smith, Stutzmann, Sumen, Tammela, Tomei, Vivienne B. Gibson, White, Worbs, Yoshida, Zinselmeyer   +40 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source