Results 121 to 130 of about 48,358 (306)
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Orbital lymphatics: do they exist? [PDF]
Introduction Although the lymphatic system was first described almost 400 years ago, it is only in very recent years that researchers have been able to identify lymphatic channels with reasonable accuracy.
Gausas RE, Dickinson AJ
core
Discussion on “Lymphatism” [PDF]
Proceedings of the Royal Society of Medicine, 1910 +11 more sources
Advanced Science, EarlyView.HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li +8 more
wiley +1 more source
CONTRACTILE RESPONSE IN ISOLATED HUMAN GROIN LYMPHATICS [PDF]
, 2017 Lymphatics from the human superficial groin removed at operation in 21 patients (one with lymphedema) were examined in vitro. Histochemically no nerves were identified with either specific catecholamine fluorescence or immunoreactivity to tyrosine ...
Alm, P +4 more
core
Intravital imaging of pulmonary lymphatics in inflammation and metastatic cancer. [PDF]
Intravital microscopy has enabled the study of immune dynamics in the pulmonary microvasculature, but many key events remain unseen because they occur in deeper lung regions.
Zhang, Dongliang +12 more
core +1 more source
Advanced Science, EarlyView.Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger +8 more
wiley +1 more source
LYMPH FLOW MECHANISM OF THE SUBPERITONEAL DIAPHRAGMATIC LYMPHATICS [PDF]
, 2017 Inorganic corpuscles like Indian ink and latex particlesas well as erythrocytes penetrate via stomataon the peritoneal surface of the diaphragm into thesubperitoneal lymphatics when injected intraperi-toneally. Electronmicroscopic examinations showedthat
Bettendorf, U
core
Cancer and lymphatic marker FOXC2 drives wound healing and fibrotic tissue formation
Frontiers in PhysiologyIntroductionThe FOXC2 transcription factor has been tied to a wide range of disease states, serving as a promising prognostic biomarker associated with aggressive basal-like human breast cancers (increased cancer invasion and metastasis).
Maia B. Granoski +14 more
doaj +1 more source
Advanced Science, EarlyView.This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan +12 more
wiley +1 more source