Results 101 to 110 of about 48,358 (306)

Combining Radiation‐Treated Tumor Vaccines With Mn‐MOF Nanoadjuvants to Amplify Radiation Induced Anti‐Tumor Immune Responses

Advanced Science, EarlyView.
Radiotherapy‐treated tumor membranes are integrated with Mn‐MOF nanoadjuvants to generate Mn@RM, a lymph node‐draining nanovaccine that delivers radiotherapy‐remodeled antigenic components. Mn@RM enhances dendritic cell activation, amplifies T cell‐mediated antitumor immunity, and synergizes with radiotherapy and PD‐1 blockade for combination cancer ...
Yiyu Wang, Qiqi Qi, Dezhong Li, Jingshi Tang, Weifeng Wang, Zushun Xu, Qi Xu, Fangfang Du, Qianyuan He   +8 more
wiley   +1 more source

Mesenteric Lymphatic Alterations Observed During DSS Induced Intestinal Inflammation Are Driven in a TLR4-PAMP/DAMP Discriminative Manner

Frontiers in Immunology, 2019
Background: Inflammatory bowel disease (IBD) is characterized by both acute and chronic phase inflammation of the gastro-intestinal (GI) tract that affect a large and growing number of people worldwide with little to no effective treatments.
Matthew Stephens, Shan Liao, Pierre-Yves von der Weid   +2 more
doaj   +1 more source

An Edible Biohybrid Platform Accomplishes In Situ Fenton‐Mediated Enteral Nanoplastics Aging and Excretion

Advanced Science, EarlyView.
An edible biohybrid platform triggers nanoplastics (NPs) aging and agglomeration by in situ generating hydroxyl radicals within the intestine. The enlarged NPs are unable to penetrate the intestine and are subsequently excreted. Simultaneously, probiotic biofilms reinforce the intestinal barrier.
Su Zhou, Anran Yan, Haowei Guo, Ping Chen, Qiang Chu   +4 more
wiley   +1 more source

Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema

Frontiers in Physiology
Secondary lymphedema is a common complication following surgical treatment of solid tumors. Although more prevalent in women due to higher breast cancer rates, men also develop lymphedema, often with more severe manifestations.
Adana-Christine Campbell, Kevin G. Kuonqui, Gopika Ashokan, Jonathan Rubin, Jinyeon Shin, Bracha L. Pollack, Arielle Roberts, Ananta Sarker, Hyeung Ju Park, Raghu P. Kataru, Andrea V. Barrio, Babak J. Mehrara   +11 more
doaj   +1 more source

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

COMPARISON OF FLUID TRANSPORT SYSTEMS IN LYMPHATICS AND VEINS [PDF]

, 2017
In the anesthetized sheep, pressure pulses generated in the feet are transmitted downstream in the veins but not in the lymphatics at normal intralymphatic pressure. When the sheep is tilted on a tilt table, gravitational changes occur in venous pressure
Roddie, IC, Pippard, C
core  

Evaluation of the Structural and Functional Dynamics of Extracellular Matrix of the Skin and Histochemical Characterization of the Dermal Interstitium

National Board of Examinations Journal of Medical Sciences
Introduction: Skin is the largest organ in the body consists of three layers, epidermis, dermis and hypodermis. Skin along with its accessories like nails, hair follicles, sweat glands and sebaceous glands forms the integumentary system.
Sridhar Krishnamoorthy, Rajan Thangarasu, Jawahar Ramasamy, Kalaivannan J, Ilankathir Sridharan   +4 more
doaj   +1 more source

Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma

OncoImmunology, 2018
Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response.
Natacha Bordry, Maria A. S. Broggi, Kaat de Jonge, Karin Schaeuble, Philippe O. Gannon, Periklis G. Foukas, Esther Danenberg, Emanuela Romano, Petra Baumgaertner, Manuel Fankhauser, Noémie Wald, Laurène Cagnon, Samia Abed-Maillard, Hélène Maby-El Hajjami, Timothy Murray, Kalliopi Ioannidou, Igor Letovanec, Pu Yan, Olivier Michielin, Maurice Matter, Melody A. Swartz, Daniel E. Speiser   +21 more
doaj   +1 more source

Impact of Lymphangiogenesis on Cardiac Remodeling After Ischemia and Reperfusion Injury

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Lymphatic vessels interconnect with blood vessels to form an elaborate system that aids in the control of tissue pressure and edema formation. Although the lymphatic system has been known to exist in a heart, little is known about the role the
Yuuki Shimizu, Rohini Polavarapu, Kattri‐Liis Eskla, Yvanna Pantner, Chad K. Nicholson, Masakazu Ishii, Daniel Brunnhoelzl, Rohit Mauria, Ahsan Husain, Nawazish Naqvi, Toyoaki Murohara, John W. Calvert   +11 more
doaj   +1 more source

Ultrasound‐Activatable Piezoelectric Hydrogel Reprograms Mitochondrial Epigenetics for Osteoarthritis Therapy via the mTOR/GATD3A Axis

Advanced Science, EarlyView.
An ultrasound‐activatable piezoelectric hydrogel reprograms chondrocyte mitochondrial epigenetics via the mTOR/GATD3A axis, clearing damaged mitochondria and alleviating osteoarthritis progression in both mouse models and human cartilage explants. ABSTRACT The avascular nature of cartilage hinders drug delivery for osteoarthritis (OA) therapy.
Hui Zheng, Pengfei Yan, Peng Liu, Chang Yan, Mengqi Zhao, Zuyong Wang, Chao Ma, Rongkai Zhang, Xi Cui, Swee Hin Teoh   +9 more
wiley   +1 more source