Results 81 to 90 of about 48,358 (306)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

VEGF-D(ilated) lymphatics as gateways for metastasis [PDF]

, 2012
VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of newintra/peritumoural capillary lymphatics. In this issue of Cancer Cell, Stacker and colleagueschallenge this notion and demonstrate that tumour-derived VEGF-D ...
Rak, Janusz
core   +1 more source

Covert cerebrospinal fluid dynamics dysfunction: evolution from conventional to innovative therapies

Frontiers in Neurology
Cerebrospinal fluid (CSF) dynamics disorders are intricately linked to diverse neurological pathologies, though they usually are mild and covert. Contemporary insights into glymphatic system function, particularly the CSF transport, drainage, and its ...
Yi Xu, Hua Yin, Lingge Li, Xiaodi Wang, Qinghua Hou   +4 more
doaj   +1 more source

Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

eLife, 2019
Heterogeneity of lymphatic vessels during embryogenesis is critical for organ-specific lymphatic function. Little is known about lymphatics in the developing kidney, despite their established roles in pathology of the mature organ.
Daniyal J Jafree, Dale Moulding, Maria Kolatsi-Joannou, Nuria Perretta Tejedor, Karen L Price, Natalie J Milmoe, Claire L Walsh, Rosa Maria Correra, Paul JD Winyard, Peter C Harris, Christiana Ruhrberg, Simon Walker-Samuel, Paul R Riley, Adrian S Woolf, Peter J Scambler, David A Long   +15 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Meningeal lymphatic drainage: novel insights into central nervous system disease

Signal Transduction and Targeted Therapy
In recent years, increasing evidence has suggested that meningeal lymphatic drainage plays a significant role in central nervous system (CNS) diseases. Studies have indicated that CNS diseases and conditions associated with meningeal lymphatic drainage ...
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng   +6 more
doaj   +1 more source

Regulation of VEGFR3 signaling in lymphatic endothelial cells

Frontiers in Cell and Developmental Biology
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) receptor 3 (VEGFR3) is the principal transmembrane receptor responsible for sensing and coordinating cellular responses to environmental lymphangiogenic stimuli in lymphatic ...
Kevin G. Kuonqui, Adana-Christine Campbell, Bracha L. Pollack, Jinyeon Shin, Ananta Sarker, Stav Brown, Hyeung Ju Park, Babak J. Mehrara, Raghu P. Kataru   +8 more
doaj   +1 more source

The Role of the Lymphatic System in Cholesterol Transport

Frontiers in Pharmacology, 2015
Reverse cholesterol transport (RCT) is the pathway for removal of peripheral tissue cholesterol and involves transport of cholesterol back to liver for excretion, starting from cellular cholesterol efflux facilitated by lipid-free apolipoprotein A1 ...
Li-Hao eHuang, Andrew eElvington, Gwendalyn J Randolph   +2 more
doaj   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Intratumoural lymphatics in benign and malignant soft tissue tumours. [PDF]

, 2008
Soft tissue sarcomas do not generally metastasise via lymphatics, and the presence or absence of lymphatic vessels within sarcomas and benign soft tissue tumours is not known.
Hollowood, K, Athanasou, NA, Williams, K, Jackson, D, Mahendra, G, Kliskey, K, Jackson, David, Athanasou, Nicholas   +7 more
core   +1 more source