Results 71 to 80 of about 48,358 (306)

Increased CSF drainage by non-invasive manipulation of cervical lymphatics [PDF]

Cerebrospinal fluid (CSF) in the subarachnoid space around the brain drains to lymph nodes in the neck, but the connections and regulation have been challenging to identify1-24. Here we used fluorescent tracers in Prox1-GFP lymphatic reporter mice to map
Won, Jinyoung, Choi, Jieun, Lee, Youngjeon, Yoon, Jin-Hui, Davis, Michael J, Kang, Hae Jin, Lim, Kyung Seob, Jeon, Chang-Yeop, Koh, Gou Young, Jin, Hokyung, Park, Hyung-Soon, Kim, Hae Jin, Jin, Cheolhwa, Jung, Junho, Baek, Seung Eun, Seo, Jincheol, Hwang, Yu Seok, Yang, Myung Jin, Hong, Seon Pyo, McDonald, Donald M   +19 more
core   +1 more source

Yap1 promotes sprouting and proliferation of lymphatic progenitors downstream of Vegfc in the zebrafish trunk

eLife, 2019
Lymphatic vascular development involves specification of lymphatic endothelial progenitors that subsequently undergo sprouting, proliferation and tissue growth to form a complex second vasculature.
Lin Grimm, Hiroyuki Nakajima, Smrita Chaudhury, Neil I Bower, Kazuhide S Okuda, Andrew G Cox, Natasha L Harvey, Katarzyna Koltowska, Naoki Mochizuki, Benjamin M Hogan   +9 more
doaj   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source

ANATOMICAL STUDY OF THE PULMONARY LYMPHATICS [PDF]

, 2017
As the result of anatomical as well as histological investigations on the lymphatics of the human lung, the authors have arrived at the following conclusions:1.
Ito, M, Nagaishi, C, Okada, Y
core  

Chronic obstructive pulmonary disease reprograms the lung into an immune organ through trained immunity, cell death networks, and immune checkpoint dysregulation

Frontiers in Medicine
IntroductionChronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory disorder characterized by persistent immune dysregulation and progressive structural deterioration of the lung.
Fatma Saaoud, Keman Xu, Yifan Lu, Ying Shao, Baosheng Han, Xianwei Wang, Xiaohua Jiang, Xiaohua Jiang, Xiaolei Liu, Jianhai Du, Hong Wang, Beata Kosmider, Xiaofeng Yang, Xiaofeng Yang   +13 more
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Dual origin of avian lymphatics [PDF]

, 2006
The earliest signs of the lymphatic vascular system are the lymph sacs, which develop adjacent to specific embryonic veins. It has been suggested that sprouts from the lymph sacs form the complete lymphatic vascular system.
Gottingen, Germany, Huang, R., Aref, Y, Schweigerer, L, Papoutsi, Maria, Schweigerer, Lothar L., Valasek, Petr, Aref, Yama, Christ, B., Christ, Bodo, Nat Eye Inst, Bethesda, Tomarev, Stanislav I., Huang, R, Wilting, J., Wilting, Jörg, Aref, Y., Wilting, J, Schweigerer, Lothar, Tomarev, S I, Valasek, P, Freiburg, Christ, B, Tomarev, S. I., Huang, Ruijin, Papoutsi, M, Valasek, P.   +25 more
core   +1 more source

Lymphatics and bone

Human Pathology, 2008
There is controversy regarding whether lymphatic vessels are present or absent in bone. Although lymphangiomas have been described in bone, lymphatic vessels have not been identified morphologically with certainty in any other benign or malignant bone tumors or in normal human bone. In this study, we determined by immunohistochemistry, using 2 specific
Edwards, James R, Williams, Kelly, Kindblom, Lars G, Meis-Kindblom, Jeanne M, Hogendoorn, Pancras C W, Hughes, David, Forsyth, Ramses G, Jackson, David, Athanasou, Nicholas A   +8 more
openaire   +4 more sources

Small Extracellular Vesicles‐Derived Circ6718 Unlocks Stromal Remodeling and Serves as a Biomarker in Gastric Cancer

Advanced Science, EarlyView.
sEVs‐circ6718 serves as a promising serum biomarker for gastric cancer early diagnosis and prognosis, promoting malignant transformation in gastric cancer cells and GC‑MSC differentiation into CAFs. sEVs‑circ6718 holds potential as a biomarker for the early diagnosis and prognostic assessment of gastric cancer.
Fan Zhang, Xueyan Zang, Dongli Wang, Rong Li, Hui Qian, Wenrong Xu, Jiajia Jiang, Yongmin Yan   +7 more
wiley   +1 more source

Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma. [PDF]

, 2003
OBJECTIVE: To examine the relationship between lymphatic vessel density and clinical and pathological variables in patients with well-differentiated papillary thyroid carcinoma.
Asa, SL, Beasley, NJ, Freeman, JL, Jackson, DG, Hall, FT   +4 more
core   +1 more source