Results 71 to 80 of about 69,579 (308)
OncoImmunology, 2019 Tumor-associated blood vessels and lymphatics are abnormal and dysfunctional. These are hallmarks of the tumor microenvironment, which has an immunosuppressive nature, such as through hypoxia. Treatment with anti-death receptor5 (DR5) monoclonal antibody
Yoko Tsukita +12 more
doaj +1 more source
eLife, 2017 Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI.
Martina Absinta +10 more
doaj +1 more source
Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett +8 more
wiley +1 more source
eLife, 2022 The discovery of meningeal lymphatic vessels that drain the CNS has prompted new insights into how immune responses develop in the brain. In this study, we examined how T cell responses against CNS-derived antigen develop in the context of infection.
Michael A Kovacs +8 more
doaj +1 more source
Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites [PDF]
, 2017 Inflammation can be protective or pathogenic depending on context and timeframe. Acute inflammation, including the accumulation of CD4 T cells, accompanies protective immune responses to pathogens, but the presence of activated CD4 T cells at sites of ...
Ammit +46 more
core +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
Dermal Lymphatic Capillaries Do Not Obey Murray's Law
Frontiers in Cardiovascular Medicine, 2022 Lymphatic vessels serve as a major conduit for the transport of interstitial fluid, immune cells, lipids and drugs. Therefore, increased knowledge about their development and function is relevant to clinical issues ranging from chronic inflammation and ...
Anne M. Talkington +6 more
doaj +1 more source
The Annals of Thoracic Surgery, 1973 Abstract The cardiac lymphatic system is well developed. Investigations related to the lymphatics of the heart are recorded as early as the seventeenth century, and with improved techniques, many studies have produced new knowledge of the system during this century. Controversy remains, however, regarding the presence of lymphatics in certain areas of
R R, Bradham, E F, Parker
openaire +2 more sources
Current Opinion in Immunology, 2018 The liver is the largest lymph producing organ. A significant increase in the number of hepatic lymphatic vessels, or lymphangiogenesis, has been reported in various liver diseases, including, but not limited to, cirrhosis, viral hepatitis and hepatocellular carcinoma.
Masatake Tanaka, Yasuko Iwakiri
openaire +2 more sources