Results 111 to 120 of about 164,625 (307)
Tumor Biology, 2017 Zhao et al. investigated the association between germline genetic polymorphisms in DPYD , the gene encoding dihydropyrimidine dehydrogenase, and (1) the risk of developing pediatric acute lymphoblastic leukemia and (2) outcome of acute lymphoblastic ...
Maarten J Deenen +4 more
doaj +1 more source
SHP2 in Cancer: From Tumor Biology to Therapeutic Targeting
Medicinal Research Reviews, EarlyView.ABSTRACT SHP2 is a tyrosine phosphatase that mediates intracellular signaling downstream of transmembrane receptors regulated by a pair of src homology 2 (SH2) domains. Its overexpression and mutation are pivotal in driving tumor progression by influencing various cancer's fundamental characteristics, such as metastasis, DNA repair, angiogenesis ...
Maryam Jama +2 more
wiley +1 more source
Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice
Haematologica, 2014 Novel therapies are needed for pediatric acute lymphoblastic leukemia resistant to conventional therapy. While emerging data suggest leukemias as possible targets of oncolytic attenuated measles virus, it is unknown whether measles virus can eradicate ...
Nike C. Lühl +10 more
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Neuroprotection, EarlyView.Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji +4 more
wiley +1 more source
Frontiers in OncologyIntroductionVariations in mutation rates among acute myeloid leukemia (AML) patients with myeloid sarcoma (MS) underscore the need for a thorough examination. This meta-analysis was conducted to fill the information gap concerning mutation frequencies in
Suvijak Untaaveesup +9 more
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, 2015 Junmei Zhao,* Chao Wang,* Yongping Song, Yuzhang Liu, Baijun FangHenan Key Lab of Experimental Haematology, Henan Institute of Haematology, Henan Tumor Hospital, Zhengzhou University, Zhengzhou, People’s Republic of China *These authors ...
Liu Y, Wang C, Fang B, Zhao J, Song Y
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Pediatric Investigation, EarlyView.Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia +12 more
wiley +1 more source
An improved acute lymphoblastic leukemia image segmentation scheme based on HSV color space
, 2016 In this paper, an improved HSV color space based Acute Lymphoblastic Leukemia (ALL) image segmentation scheme is proposed to improve accuracy of segmentation on digital microscope color images, especially for those taken in non;uniform background ...
Yao, Di +4 more
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Cross‐Platform Comparison of Chemoproteomics Workflows: Orbitrap‐TMT Versus timsTOF‐diaPASEF
PROTEOMICS, EarlyView.ABSTRACT Chemoproteomics aims to achieve precise and comprehensive quantification of protein–small molecule interactions, yet methodological comparisons across quantitative proteomics workflows remain scarce. Here, we systematically benchmark tandem mass tag data‐dependent acquisition (TMT‐DDA) on Orbitrap Exploris/Eclipse instruments against label ...
Ursula M. Glocker +7 more
wiley +1 more source
Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia
Journal of Medical Imaging and Radiation Oncology, EarlyView.ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes +2 more
wiley +1 more source