Results 41 to 50 of about 160,145 (308)

Selective targeting of NOTCH-1 for therapeutic purposes in xenograft models of T-acute lymphoblastic leukemia [PDF]

, 2013
T-cell acute lymphoblastic leukemia (T-ALL) is an heterogeneous disease, characterized by several genetic alterations and polymorphic clinical features both in children and adults.
Agnusdei, Valentina
core  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia

Haematologica, 2014
T-cell acute lymphoblastic leukemia arises from the leukemic transformation of developing thymocytes and results from cooperative genetic lesions. Inactivation of the PHF6 gene is frequently observed in T-cell acute lymphoblastic leukemia, suggesting an ...
Evelien Mets, Gert Van Peer, Joni Van der Meulen, Michael Boice, Tom Taghon, Steven Goossens, Pieter Mestdagh, Yves Benoit, Barbara De Moerloose, Nadine Van Roy, Bruce Poppe, Jo Vandesompele, Hans-Guido Wendel, Pieter Van Vlierberghe, Frank Speleman, Pieter Rondou   +15 more
doaj   +1 more source

Preclinical Evidence for the Efficacy of CD79b Immunotherapy in B-cell Precursor Acute Lymphoblastic Leukemia [PDF]

, 2022
Patients with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) have a favorable prognosis. However, current treatment protocols are based on intensive cytotoxic chemotherapy and therapy options are limited when patients relapse. Hence, there is an
Gina Münch, Andrew G. Polson, Monika Brüggemann, Martin Schrappe, Denis M. Schewe, Cario, Gunnar, Vogiatzi, Fotini, Ulf D. Kahlert, Jumaa, Hassan, Christian Vokuhl, Mayar, Ahmad, Fotini Vogiatzi, Anna Dietterle, Vokuhl, Christian, Lennart Lenk, Schewe, Denis M., Schüler, Thomas, Münch, Gina, Schewe, Denis M, Winterberg, Dorothee, Spory, Lea, Lea Spory, Thomas Valerius, Polson, Andrew G., Richter, Julia, Ameera Alsadeq, Matthias Peipp, Dietterle, Anna, Kahlert, Ulf D., Brüggemann, Monika, Alsadeq, Ameera, Anna Laqua, Gunnar Cario, Valerius, Thomas, Schrappe, Martin, Ahmad Mayar, Hobeika, Elias, Elias Hobeika, Lenk, Lennart, Peipp, Matthias, Julia Richter, Dorothee Winterberg, Hassan Jumaa, Laqua, Anna, Thomas Schüler, Kahlert, Ulf D, Polson, Andrew G   +46 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia

, 2008
The intrachromosomal amplification of chromosome 21 (iAMP21) was identifiedas a novel and prognositically important acquired chromosomal abnormality inchildhood acute lymphoblastic leukaemia (ALL).
Robinson, Hazel M.
core   +1 more source

Therapy-related acute lymphoblastic leukemia has distinct clinical and cytogenetic features compared to de novo acute lymphoblastic leukemia, but outcomes are comparable in transplanted patients

Haematologica, 2018
Therapy-related acute lymphoblastic leukemia remains poorly defined due to a lack of large data sets recognizing the defining characteristics of this entity.
Ibrahim Aldoss, Tracey Stiller, Ni-Chun Tsai, Joo Y. Song, Thai Cao, N. Achini Bandara, Amandeep Salhotra, Samer Khaled, Ahmed Aribi, Monzr M. Al Malki, Matthew Mei, Haris Ali, Ricardo Spielberger, Margaret O’Donnell, David Snyder, Thomas Slavin, Ryotaro Nakamura, Anthony S. Stein, Stephen J. Forman, Guido Marcucci, Vinod Pullarkat   +20 more
doaj   +1 more source

Oral health management in children with acute lymphoblastic leukemia

口腔疾病防治, 2021
Acute lymphoblastic leukemia is the most common type of leukemia in children. In recent years, the treatment and prognosis of acute lymphoblastic leukemia in children have improved significantly. However, acute lymphoblastic leukemia itself and treatment
TANG Yawen, ZHANG Lin, YANG Xue, ZOU Jing, WANG Yan   +4 more
doaj   +1 more source

Randomized study of reduced-intensity chemotherapy combined with imatinib in adults with Ph-positive acute lymphoblastic leukemia

, 2015
In this study, we randomly compared high doses of the tyrosine kinase inhibitor imatinib combined with reduced-intensity chemotherapy (arm A) to standard imatinib/hyperCVAD (cyclophosphamide/vincristine/doxorubicin/dexamethasone) therapy (arm B) in 268 ...
Cayuela, Jean-Michel, Huguet, Françoise, Maury, Sébastien, Chalandon, Yves, Lepretre, S., Ifrah, N., Berthon, C., Chevret, S., Escoffre-Barbe, Martine, Dombret, Hervé, Lepretre, Stéphane, Rousselot, Philippe, Thomas, X., Escoffre-Barbe, M., Maury, S., Tavernier, E., Hayette, Sandrine, Tavernier, Emmanuelle, Berthon, Céline, Lhéritier, V., Raffoux, E., Lafage-Pochitaloff, M., Cayuela, J.M., Abbal, C., Chalandon, Y., Thomas, Xavier, Leguay, Thibaut, Chevret, Sylvie, Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL), Leguay, T., Rousselot, P., Lambert, Jean-François, Abbal, Claire, Hayette, S., Lafage-Pochitaloff, Marina, Lhéritier, Véronique, Huguet, F., Lambert, J.F., Raffoux, Emmanuel, Ifrah, Norbert, Dombret, H.   +40 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source