Results 61 to 70 of about 164,625 (307)

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

open access: yesHaematologica, 2017
Relapsed acute lymphoblastic leukemia is the most common cause of cancer-related mortality in young people and new therapeutic strategies are needed to improve outcome.
Zach A. Dixon   +6 more
doaj   +1 more source

Lymphoblastic Lymphoma of the Palate [PDF]

open access: yesBaylor University Medical Center Proceedings, 2017
Lymphoblastic lymphomas are neoplasms of immature or precursor lymphoid cells with no or limited bone marrow involvement, whose clinical presentation varies according to the immunophenotype. While mediastinal involvement is predominant in T-lymphoblastic lymphomas, B-lymphoblastic lymphomas frequently involve nodal sites.
Rakul, Nambiar   +3 more
openaire   +2 more sources

Fusarium sp. infection in a patient with Acute Lymphoblastic Leukaemia [PDF]

open access: yes, 2013
In the past two decades, Fusarium species have been increasingly recognized as serious pathogens in immunocompromised patients. The outcome of fusariosis in the context of severe persistent neutropaenia has been almost universally fatal. The treatment
Na, S.L., Tan, R., Gan, G.G., Ng, K.P.
core  

Acute lymphoblastic leukemia in Down syndrome [PDF]

open access: yes, 2018
Review on acute lymphoblastic leukemia in Down syndrome, with data on clinics, pathology, and involved ...
Chisholm, Karen M
core   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang   +8 more
wiley   +1 more source

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system

open access: yesHaematologica, 2017
Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed ...
Ameera Alsadeq   +10 more
doaj   +1 more source

Acute Lymphoblastic Leukemia Presenting with Right Atrial Thrombosis and Massive Pulmonary Embolism: A Case Report

open access: yesMiddle East Journal of Cancer, 2020
Thrombosis is a rare complication of acute lymphoblastic leukemia usually occurring following chemotherapy. The most common reported site is intracranial thrombosis.
Amirataollah Hiradfar   +2 more
doaj   +1 more source

del(9p) in Acute Lymphoblastic Leukemia [PDF]

open access: yes, 2017
Review on del(9p) in acute lymphoblastic leukemia, with data on clinics, and the genes ...
Mohamed, Anwar N
core   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

open access: yesAdvanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu   +5 more
wiley   +1 more source

The prognosis of CALM-AF10-positive adult T-cell acute lymphoblastic leukemias depends on the stage of maturation arrest

open access: yesHaematologica, 2013
CALM-AF10 (also known as PICALM-MLLT10) is the commonest fusion protein in T-cell acute lymphoblastic leukemia, but its prognostic impact remains unclear.
Raouf Ben Abdelali   +19 more
doaj   +1 more source

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