Results 11 to 20 of about 657,458 (324)

B cell MHC haplotype affects follicular inclusion, germinal center participation and plasma cell differentiation in a mouse model of lupus

Frontiers in Immunology, 2023
IntroductionMHC class II molecules are essential for appropriate immune responses against pathogens but are also implicated in pathological responses in autoimmune diseases and transplant rejection.
Camilla Wibrand, Thomas R. Wittenborn, Lasse Frank Voss, Lasse Frank Voss, Gudrun Winther, Lisbeth Jensen, Alexey Ferapontov, Alexey Ferapontov, Alexey Ferapontov, Sofie V. Fonager, Cecilia Fahlquist-Hagert, Søren E. Degn, Søren E. Degn   +12 more
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Generation of High Quality Memory B Cells

Frontiers in Immunology, 2022
Protection against pathogen re-infection is mediated, in large part, by two humoral cellular compartments, namely, long-lived plasma cells and memory B cells.
Takeshi Inoue, Ryo Shinnakasu, Tomohiro Kurosaki, Tomohiro Kurosaki, Tomohiro Kurosaki   +4 more
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Antigen presentation by B cells enables epitope spreading across an MHC barrier

Nature Communications, 2023
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE)
Cecilia Fahlquist-Hagert, Thomas R. Wittenborn, Ewa Terczyńska-Dyla, Kristian Savstrup Kastberg, Emily Yang, Alysa Nicole Rallistan, Quinton Raymond Markett, Gudrun Winther, Sofie Fonager, Lasse F. Voss, Mathias K. Pedersen, Nina van Campen, Alexey Ferapontov, Lisbeth Jensen, Jinrong Huang, John D. Nieland, Cees E. van der Poel, Johan Palmfeldt, Michael C. Carroll, Paul J. Utz, Yonglun Luo, Lin Lin, Søren E. Degn   +22 more
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Dynamic 3D Locus Organization and Its Drivers Underpin Immunoglobulin Recombination

Frontiers in Immunology, 2021
A functional adaptive immune system must generate enormously diverse antigen receptor (AgR) repertoires from a limited number of AgR genes, using a common mechanism, V(D)J recombination.
Carolyn H. Rogers, Olga Mielczarek, Anne E. Corcoran   +2 more
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Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

Cell Reports, 2017
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development.
Sonia Agüera-González, Oliver T. Burton, Elena Vázquez-Chávez, Céline Cuche, Floriane Herit, Jérôme Bouchet, Rémi Lasserre, Iratxe del Río-Iñiguez, Vincenzo Di Bartolo, Andrés Alcover   +9 more
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Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Nature Communications, 2019
Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal ...
Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman   +6 more
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Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman   +14 more
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Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation

Nature Communications, 2017
Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a ...
Jason Pinger, Shanin Chowdhury, F. Nina Papavasiliou   +2 more
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CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

Frontiers in Immunology, 2017
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Ester Marina-Zárate, Arantxa Pérez-García, Almudena R. Ramiro   +2 more
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Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

Nature Communications, 2021
The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and ...
Haiyan Zhao, Natalie Young, Jens Kalchschmidt, Jenna Lieberman, Laila El Khattabi, Rafael Casellas, Francisco J. Asturias   +6 more
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