Results 11 to 20 of about 958,254 (366)

Images in cardiovascular medicine : multiphoton microscopy for three-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery [PDF]

, 2007
Two recent elegant studies have shown that in apolipoprotein-E– deficient mice, the lamina adventitia is a major site of arterial wall inflammation associated with lymphocyte infiltration into atherosclerotic arteries and with formation of adventitial ...
Baker, Andrew H., Brewer, James M., Garside, Paul, Ialenti, Armando, Kennedy, Simon, Maffia, Pasquale, McInnes, Iain B., Zinselmeyer, Bernd H.   +7 more
core   +1 more source

Sensitivity of activated human lymphocytes to cyclosporine and its metabolites [PDF]

, 1988
Alloreactive T cells generated as clones from mixed lymphocyte cultures, or propagated from heart or liver transplant biopsies, were tested for secondary proliferation measured in the primed lymphocyte test in the presence of Cyclosporine A and ...
Burckart, G, Duquesnoy, RJ, Makowka, L, Murase, N, Starzl, TE, Van Thiel, DH, Venkataramanan, R, Wang, CP, Zeevi, A   +8 more
core   +1 more source

Heterochronic faecal transplantation boosts gut germinal centres in aged mice

Nature Communications, 2019
Microbiota impacts all major aspects of physiology, but little is known about its effects on age-related changes in immune responses. Here the authors show that gut microbiota transfer between adult and old mice increases local but not systemic germinal ...
Marisa Stebegg, Alyssa Silva-Cayetano, Silvia Innocentin, Timothy P. Jenkins, Cinzia Cantacessi, Colin Gilbert, Michelle A. Linterman   +6 more
doaj   +1 more source

Structure of mammalian Mediator complex reveals Tail module architecture and interaction with a conserved core

Nature Communications, 2021
The Mediator complex regulates RNA polymerase II transcription in all eukaryotes. The mammalian Mediator cryo-EM structure reveals the architecture of previously unresolved Tail module and suggests its regulatory role in the complex conformation and ...
Haiyan Zhao, Natalie Young, Jens Kalchschmidt, Jenna Lieberman, Laila El Khattabi, Rafael Casellas, Francisco J. Asturias   +6 more
doaj   +1 more source

The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]

, 1984
During the acute cytolytic T lymphocyte (CTL) response of mice to infection with the murine cytomegalovirus two independent populations of activated interleukin-receptive CTL precursors can be demonstrated.
Ada, Beyer, Chantler, Costanzo, Ebeling, Honess, Hudson, Jackson, Kendall, Kim, Koszinowski, Koszinowski, Laemmli, Mulligan, Osborn, Pfizenmaier, Reddehase, Robinson, Sethi, Sethi, Spear, Svedmyr, Ueda, Zinkernagel, Zinkernagel, Zinkernagel   +25 more
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Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination

eLife, 2020
Germinal centres (GCs) are T follicular helper cell (Tfh)-dependent structures that form in response to vaccination, producing long-lived antibody secreting plasma cells and memory B cells that protect against subsequent infection. With advancing age the
Marisa Stebegg, Alexandre Bignon, Danika Lea Hill, Alyssa Silva-Cayetano, Christel Krueger, Ine Vanderleyden, Silvia Innocentin, Louis Boon, Jiong Wang, Martin S Zand, James Dooley, Jonathan Clark, Adrian Liston, Edward Carr, Michelle A Linterman   +14 more
doaj   +1 more source

TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents [PDF]

, 2017
BACKGROUND: Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignant lymphocytosis remains ...
Amodeo, Rachele, Bove, Maurizio, Cox, Maria Christina, D'Amelio, Raffaele, DI ROSA, Roberta, Lagana', Bruno, Markovic, Milica, PICCHIANTI DIAMANTI, Andrea, Pilozzi, Emanuela, Rosado, Maria Manuela, Salemi, Simonetta, Sorgi, Maria Laura   +11 more
core   +1 more source

CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

Frontiers in Immunology, 2017
In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA.
Ester Marina-Zárate, Arantxa Pérez-García, Almudena R. Ramiro   +2 more
doaj   +1 more source

Stromal cells differentially regulate neutrophil and lymphocyte recruitment through the endothelium [PDF]

, 2010
Stromal fibroblasts modify the initial recruitment of leucocytes by endothelial cells (EC), but their effects on subsequent transendothelial migration remain unclear.
Arisaka, Balashov, Bijuklic, Bradfield, Brezinschek, Buckley, Burger, Burman, Butler, Buttrum, Carlos, Chakravorty, Chappell, Cinamon, Cinamon, Colditz, Cooke, Covas, Crisan, Curbishley, Denton, Dore-Duffy, Edwards, Fedyk, Filer, Firestein, Goddard, Hardingham, Holt, Khandoga, Koch, Kunz-Schughart, Lally, Ley, Li, Liu, Luscinskas, Luu, Luu, Martin, McGettrick, McGettrick, McGettrick, Middleton, Mohan, Mul, Nanki, Oberringer, Oppenheimer-Marks, Pablos, Piali, Pietschmann, Proost, Pruenster, Rainger, Rainger, Rajkumar, Ranjbaran, Ransohoff, Salmon, Shamri, Shiwen, Shulman, Sims, Smith, Sorrell, Szczepanek, Taylor, Traktuev, Tull, Ueno, Van Lint, Wang   +72 more
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Variant surface glycoprotein density defines an immune evasion threshold for African trypanosomes undergoing antigenic variation

Nature Communications, 2017
Trypanosoma brucei evades the host immune system through replacement of a variant surface glycoprotein (VSG) coat. Here, the authors show that VSG replacement takes several days to complete, and the parasite is vulnerable to the host immune system for a ...
Jason Pinger, Shanin Chowdhury, F. Nina Papavasiliou   +2 more
doaj   +1 more source