Results 41 to 50 of about 935,381 (311)

The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia [PDF]

, 1988
We describe the effect of splenic irradiation (SI) (0,5–1 Gy weekly) on lymphocyte subpopulations for 7 patients with progressive B chronic B-lymphocytic leukemia (B-CLL).
Aabo, Anderson, Boumsell, Byhardt, Catovsky, Durum, Enno, Foa, Foa, Herrman, Horning, Johnson, Markey, Martin, McCann, Mills, Mittelman, Paule, Platsoucas, Roncadin, Rovston, Spivak, Terstappen, Terstappen, Vann   +24 more
core   +3 more sources

T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity

iScience
Summary: Autoantibodies generated in germinal centers (GCs) contribute to the pathogenesis of autoimmune diseases. GCs are controlled by specialized FoxP3+ T-follicular regulatory cells (Tfr), but their role in established autoimmunity is unclear.
Cecilia Fahlquist-Hagert, Thomas Rea Wittenborn, Mattias Krogh Pedersen, Lisbeth Jensen, Søren Egedal Degn   +4 more
doaj   +1 more source

Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function

Frontiers in Immunology, 2017
Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease in vivo but the mechanism by which this ...
Alexandre Bignon, Alan P. Watt, Michelle A. Linterman   +2 more
doaj   +1 more source

AutoSpill is a principled framework that simplifies the analysis of multichromatic flow cytometry data

Nature Communications, 2021
Flow cytometry allows the simultaneous quantification of many markers in and on a cell, but the analysis of such data is complicated. Here, the authors propose AutoSpill, a framework that facilitates the analysis of such data by automating parts of the ...
Carlos P. Roca, Oliver T. Burton, Václav Gergelits, Teresa Prezzemolo, Carly E. Whyte, Richard Halpert, Łukasz Kreft, James Collier, Alexander Botzki, Josef Spidlen, Stéphanie Humblet-Baron, Adrian Liston   +11 more
doaj   +1 more source

MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction

Frontiers in Immunology, 2022
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is referred ...
François Van Laethem, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer   +6 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Polypyrimidine tract-binding proteins are essential for B cell development

eLife, 2020
Polypyrimidine tract-binding protein 1 (PTBP1) is a RNA-binding protein (RBP) expressed throughout B cell development. Deletion of Ptbp1 in mouse pro-B cells results in upregulation of PTBP2 and normal B cell development.
Elisa Monzón-Casanova, Louise S Matheson, Kristina Tabbada, Kathi Zarnack, Christopher WJ Smith, Martin Turner   +5 more
doaj   +1 more source

Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice

Nature Communications, 2022
Here the authors show that a high-fat diet in pregnant mice can release silencing of the imprinted Dlk1 locus in multiple generations of offspring.
Mathew Van de Pette, Andrew Dimond, António M. Galvão, Steven J. Millership, Wilson To, Chiara Prodani, Gráinne McNamara, Ludovica Bruno, Alessandro Sardini, Zoe Webster, James McGinty, Paul M. W. French, Anthony G. Uren, Juan Castillo-Fernandez, William Watkinson, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Gavin Kelsey, Amanda G. Fisher   +19 more
doaj   +1 more source

Neutrophil-to-lymphocyte ratio as a bladder cancer biomarker: assessing prognostic and predictive value in SWOG 8710 [PDF]

, 2017
No abstract ...
Advanced Bladder Cancer (ABC) Meta-analysis Collaboration, Asano, Ferro, Gondo, Grenader, Guthrie, Krane, Linton, Lorente, Mitchell, Ojerholm, Templeton, Viers   +12 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source