Results 41 to 50 of about 1,723,798 (355)

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

EMBO Molecular Medicine, 2018
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour   +9 more
doaj   +1 more source

Can follicular helper T cells be targeted to improve vaccine efficacy? [version 1; referees: 3 approved]

F1000Research, 2016
The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting ...
Michelle A. Linterman, Danika L. Hill
doaj   +1 more source

Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI).

Translational Lung Cancer Research, 2019
Background Currently, there is no single validated biomarker which can prognosticate survival in patients with stage IV non-small cell lung cancer (NSCLC). This study examines the prognostic significance of four biomarkers: neutrophil to lymphocyte ratio
Hiren Mandaliya, Mark Jones, C. Oldmeadow, I. Nordman   +3 more
semanticscholar   +1 more source

Neutrophil-to-lymphocyte ratio as a bladder cancer biomarker: assessing prognostic and predictive value in SWOG 8710 [PDF]

, 2017
No abstract ...
Advanced Bladder Cancer (ABC) Meta-analysis Collaboration, Asano, Ferro, Gondo, Grenader, Guthrie, Krane, Linton, Lorente, Mitchell, Ojerholm, Templeton, Viers   +12 more
core   +1 more source

RNA editing generates cellular subsets with diverse sequence within populations

Nature Communications, 2016
RNA editing rate detected from bulk RNA-seq data can vary widely. Here, by constructing a hierarchical Bayesian model, the authors report substantial variance in editing signatures detected by RNA-seq data from both single cells and a cognate bulk sample.
Dewi Harjanto, Theodore Papamarkou, Chris J. Oates, Violeta Rayon-Estrada, F. Nina Papavasiliou, Anastasia Papavasiliou   +5 more
doaj   +1 more source

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Cell Reports, 2017
T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells ...
Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen   +6 more
doaj   +1 more source

MYC’s Fine Line Between B Cell Development and Malignancy

Cells, 2020
The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of
Oriol de Barrios, Ainara Meler, Maribel Parra   +2 more
doaj   +1 more source

Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states

Nature Communications, 2021
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood.
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn   +7 more
doaj   +1 more source

Systemic immune‐inflammation index, neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio can predict clinical outcomes in patients with metastatic non‐small‐cell lung cancer treated with nivolumab

Journal of clinical laboratory analysis (Print), 2019
Explore markers to predict the clinical outcomes of checkpoint inhibitors have high unmet needs. The following study investigates whether hematologic parameter such as systemic immune‐inflammation index (SII), neutrophil‐to‐lymphocyte ratio (NLR ...
Jingjing Liu, Shuang Li, Shuang Zhang, Y. Liu, Lixia Ma, Jing Zhu, Y. Xin, Ying Wang, Changliang Yang, Ying Cheng   +9 more
semanticscholar   +1 more source

T-follicular regulatory cells expand to control germinal center plasma cell output but fail to curb autoreactivity

iScience
Summary: Autoantibodies generated in germinal centers (GCs) contribute to the pathogenesis of autoimmune diseases. GCs are controlled by specialized FoxP3+ T-follicular regulatory cells (Tfr), but their role in established autoimmunity is unclear.
Cecilia Fahlquist-Hagert, Thomas Rea Wittenborn, Mattias Krogh Pedersen, Lisbeth Jensen, Søren Egedal Degn   +4 more
doaj   +1 more source