Results 41 to 50 of about 1,637,376 (389)

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

Nature, 2016
Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death. Non-alcoholic fatty liver disease (NAFLD) affects a large proportion of the US population and is considered to be a metabolic predisposition to liver cancer. However,
Chi Ma, A. Kesarwala, T. Eggert, J. Medina‐Echeverz, D. Kleiner, P. Jin, D. Stroncek, M. Terabe, V. Kapoor, Mei ElGindi, Miaojun Han, A. Thornton, Haibo Zhang, Michèle Egger, Ji Luo, D. Felsher, D. McVicar, A. Weber, M. Heikenwalder, T. Greten   +19 more
semanticscholar   +1 more source

Assessing the impact of an antigen-specific antibody response on atherosclerosis development in mice

STAR Protocols, 2023
Summary: The antibody immune response plays a critical role in atherosclerosis. Here, we present a protocol for assessing the impact of an antigen-specific germinal center antibody response on atherosclerosis development, using a pro-atherogenic mouse ...
Alberto Del Monte-Monge, Inmaculada Martos-Folgado, Ana Rodríguez-Ronchel, Almudena R. Ramiro   +3 more
doaj  

Cellular Stress in the Context of an Inflammatory Environment Supports TGF-β-Independent T Helper-17 Differentiation

Cell Reports, 2017
T helper-17 (Th17) cells are associated with inflammatory disorders and cancer. We report that environmental conditions resulting in cellular stress, such as low oxygen, glucose, and isotonic stress, particularly enhance the generation of Th17 cells ...
Verena Brucklacher-Waldert, Cristina Ferreira, Marisa Stebegg, Olivier Fesneau, Silvia Innocentin, Julien C. Marie, Marc Veldhoen   +6 more
doaj   +1 more source

MYC’s Fine Line Between B Cell Development and Malignancy

Cells, 2020
The transcription factor MYC is transiently expressed during B lymphocyte development, and its correct modulation is essential in defined developmental transitions. Although temporary downregulation of MYC is essential at specific points, basal levels of
Oriol de Barrios, Ainara Meler, Maribel Parra   +2 more
doaj   +1 more source

Widespread reorganisation of pluripotent factor binding and gene regulatory interactions between human pluripotent states

Nature Communications, 2021
The role of transcriptional enhancers and 3D chromatin organisation in coordinating the transition from naive to primed pluripotency remains poorly understood.
Peter Chovanec, Amanda J. Collier, Christel Krueger, Csilla Várnai, Claudia I. Semprich, Stefan Schoenfelder, Anne E. Corcoran, Peter J. Rugg-Gunn   +7 more
doaj   +1 more source

T-cell responses in oiled guillemots and swans in a rehabilitation setting [PDF]

, 2013
This article has been accepted for publication in the Archives of Environmental Contamination and Toxicology. The final version can be accessed from the link below.This article has been made available through the Brunel Open Access Publishing Fund ...
A Balseiro, C Alonso-Alvarez, DB Peakall, ET Lavoie, FA Leighton, FA Leighton, FA Leighton, Gera M. Troisi, GM Troisi, GM Troisi, GM Troisi, JE Smits, JE Smits, KA Grasman, KA Grasman, KA Sagerup, KT Briggs, M Grantham, REA Madill, S Wanless, SH Newman, TE Rocke, WN Holmes   +22 more
core   +1 more source

RNA editing generates cellular subsets with diverse sequence within populations

Nature Communications, 2016
RNA editing rate detected from bulk RNA-seq data can vary widely. Here, by constructing a hierarchical Bayesian model, the authors report substantial variance in editing signatures detected by RNA-seq data from both single cells and a cognate bulk sample.
Dewi Harjanto, Theodore Papamarkou, Chris J. Oates, Violeta Rayon-Estrada, F. Nina Papavasiliou, Anastasia Papavasiliou   +5 more
doaj   +1 more source

Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function

Frontiers in Immunology, 2017
Treatments to limit T cell activation are essential for managing autoimmune and inflammatory disorders. The B subunit of Escherichia coli heat-labile enterotoxin (EtxB) is known to ameliorate inflammatory disease in vivo but the mechanism by which this ...
Alexandre Bignon, Alan P. Watt, Michelle A. Linterman   +2 more
doaj   +1 more source

Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice

Nature Communications, 2022
Here the authors show that a high-fat diet in pregnant mice can release silencing of the imprinted Dlk1 locus in multiple generations of offspring.
Mathew Van de Pette, Andrew Dimond, António M. Galvão, Steven J. Millership, Wilson To, Chiara Prodani, Gráinne McNamara, Ludovica Bruno, Alessandro Sardini, Zoe Webster, James McGinty, Paul M. W. French, Anthony G. Uren, Juan Castillo-Fernandez, William Watkinson, Anne C. Ferguson-Smith, Matthias Merkenschlager, Rosalind M. John, Gavin Kelsey, Amanda G. Fisher   +19 more
doaj   +1 more source

MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction

Frontiers in Immunology, 2022
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antigens is referred ...
François Van Laethem, François Van Laethem, Abhisek Bhattacharya, Marco Craveiro, Jinghua Lu, Peter D. Sun, Alfred Singer   +6 more
doaj   +1 more source