Results 251 to 260 of about 399,802 (272)

Ion channels and lymphocyte activation

Immunology Letters, 2004
The ion channels expressed by T lymphocytes play key roles in the control of the membrane potential and calcium signaling, thereby affecting signal transduction pathways that lead to the activation of these cells following antigenic stimulation. Disruption of these pathways can attenuate or prevent the response of T-cells to antigenic challenge ...
Panyi, György, Varga, Zoltán, Gáspár, Rezső   +2 more
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Lymphocyte Activation in Health and Disease

Critical Reviews in Immunology, 1997
Lymphocytes employ a complex assembly of signaling elements that have been organized on a spatiotemporal map to define their role in stimulating both proliferation and apoptosis. The antigen/major histocompatibility complex (MHC) initiates the sequence by organizing the assembly of an active T-cell receptor (TCR) complex responsible for transmitting ...
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Tempering lymphocyte activation

Science, 2020
Immunodeficiency Diagnosis and treatment of inborn errors in immunity remain a challenge. Salzer et al. studied two siblings who were hospitalized for recurrent pediatric infections. Exome sequencing and functional analyses helped to identify homozygous loss-of-function mutations in genes encoding the protein HEM1 in both individuals.
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T lymphocyte activation signals.

Ciba Foundation symposium, 1992
Activation of T lymphocytes results in immediate biochemical changes including increases in intracellular calcium levels, activation of protein kinase C (PKC) and changes in tyrosine phosphorylation. In T cells recent studies have indicated that activation of the guanine nucleotide-binding proteins p21ras is mediated by PKC, which suggests that the ...
Julian Downward, Jonathan D. Graves, Doreen A. Cantrell, Susan C. Lucas, Manuel Izquierdo   +4 more
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Monitoring RhoGTPase Activity in Lymphocytes

2010
L-selectin is a cell adhesion molecule (CAM) that is essential for the tethering and subsequent rolling of naïve lymphocytes along the luminal wall of postcapillary venules entering lymph nodes. As with many CAMs, L-selectin has the capacity to transduce intracellular signals in response to ligand binding. This implicates CAMs involved in tethering and
Zarrouk, M, Killock, D, Ivetic, A
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T Lymphocyte Activation in Graves' Disease

Endocrine Research, 1994
We examined the proliferative response of T lymphocytes from thirty-eight patients with Graves' disease (17 untreated thyrotoxic and 30 euthyroid on antithyroid medication) to phytohemagglutinin, anti-CD3 MoAb and phorbol esters, as well as the capacities of these lymphocytes to produce interleukin 2 and the density of interleukin 2 receptors and major
A. Durántez, Mónica Marazuela, Juan A. Vargas, Melchor Alvarez-Mon   +3 more
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PARAMETERS OF LYMPHOCYTE ACTIVATION

1977
Publisher Summary This chapter discusses a few dissociations found among the parameters of activation and present models, which may be useful in understanding the meaning of lymphocyte activation. It also highlights several metabolic processes that have been reported to change following the stimulation of lymphocytes.
Gary R. Klimpel, David O. Lucas
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STUDIES OF LYMPHOCYTE ACTIVATION

1979
Publisher Summary This chapter presents some studies of lymphocyte activation. The results of these studies suggested that exogenous arachidonic acid can stimulate the incorporation of tritiated thymidine into DNA; that inhibitors of arachidonic acid metabolism, particularly those affecting thromboxane synthesis, inhibit the DNA synthetic response to
Charles W. Parker, James P. Kelly
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T-LYMPHOCYTE ACTIVATION AND ALLERGY

The Lancet, 1988
CANONICA, GIORGIO, BAGNASCO, MARCELLO
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Off‐Signals in Lymphocyte Activation

Scandinavian Journal of Immunology, 1976
High‐dose unresponsiveness to concanavalin A affected T and B lymphocytes equally, although only T cells were activated by Con A. Thus, activation and inactivation signals art totally unrelated, the latter also lacking target cell specificity. The off‐signal caused cell death and is probably biologically unimportant.
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