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Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

open access: yesAdvanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang   +18 more
wiley   +1 more source
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Gene of the month: lymphocyte-activation gene 3 (LAG-3)

Journal of Clinical Pathology, 2021
Lymphocyte-activation gene 3 (LAG-3) is a coreceptor found on activated T-lymphocytes activated B-lymphocytes and natural killer (NK) cells. It is closely related to CD4 where it shares multiple common and divergent features. It contains specific binding
M. Lythgoe   +4 more
semanticscholar   +1 more source

Lymphocyte Activation

Scandinavian Journal of Immunology, 1973
Abstracts of papers presented at the Nordic Symposium, 1st and 2nd of December, 1972, in Helsinki, Finland.The meeting was sponsored by:Minerva Institute for Medical Research, Folkhälsen Institute for Genetics, Swedish Cancer Society, Study Group for Mitogenic Substances, and arranged by: Theodor H. Weber & Valdemar T. Skoog.The topics covered were:
openaire   +2 more sources

B lymphocyte activation

Immunology Today, 1981
A review focussing on the lessons learned from polyclonal activation of B cells.
openaire   +2 more sources

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