Results 291 to 300 of about 4,241,016 (384)

Progress of lymphocyte activation gene 3 and programmed cell death protein 1 antibodies for cancer treatment: A review. [PDF]

Biomol Biomed
Li YQ, Chen XM, Si GF, Yuan XM.
europepmc   +1 more source

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Advanced Therapeutics, EarlyView.
Emerging microphysiological systems reproduce the spatial, biochemical, and cellular complexity of the tumor microenvironment, surpassing 2D cultures and murine models. By integrating patient‐derived tumors, perfusable vasculature, and immune trafficking, these organ‐on‐chip platforms reveal mechanisms of immune evasion, predict therapeutic responses ...
Fabiana Moresi, Francesco Noto, Jyothsna Vasudevan, Xavier Bisteau, Giulia Adriani, Andrea Pavesi   +5 more
wiley   +1 more source

Unlocking therapeutic potential: Targeting lymphocyte activation Gene-3 (LAG-3) with fibrinogen-like protein 1 (FGL1) in systemic lupus erythematosus. [PDF]

J Transl Autoimmun
Wang B, Zhang B, Wu M, Xu T.
europepmc   +1 more source

Activation of a tyrosine protein kinase is an early event in the stimulation of T lymphocytes by interleukin-2.

, 1988
E M Saltzman, R R Thom, J E Casnellie
openalex   +1 more source

Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency

Nature, 2002
H. Chun, Lixin Zheng, Manzoor Ahmad, Jin Wang, Jin Wang, C. Speirs, R. Siegel, J. Dale, J. Puck, Joie N. Davis, C. Hall, S. Skoda-Smith, T. Atkinson, S. Straus, M. Lenardo   +14 more
semanticscholar   +1 more source

Cytokine Engineering Approaches for Regenerative Medicine

Advanced Therapeutics, EarlyView.
Engineered cytokines represent a powerful strategy to promote tissue repair and regeneration by precisely modulating immune responses. This review highlights recent advances in cytokine engineering, including strategies to enhance half‐life, improve tissue and cell targeting, and control receptor signaling.
Shiyi Li, Wenhao You, Mikaël M. Martino
wiley   +1 more source

Comprehensive analysis of signaling lymphocyte activation molecule family as a prognostic biomarker and correlation with immune infiltration in clear cell renal cell carcinoma. [PDF]

Oncol Lett
Song N, Wang Z, Shi P, Cui K, Fan Y, Zeng L, Di W, Li J, Su W, Wang H.   +9 more
europepmc   +1 more source

Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy

Advanced Therapeutics, EarlyView.
This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar, Weiwei Guo, Xin Shen, Yimeng Fang, Yilin Liu, Peng‐Yuan Wang, Roey Elnathan, Yaping Chen   +7 more
wiley   +1 more source

Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma. [PDF]

J Clin Oncol
Hamid O, Lewis KD, Weise A, McKean M, Papadopoulos KP, Crown J, Kim TM, Lee DH, Thomas SS, Mehnert J, Kaczmar J, Lakhani NJ, Kim KB, Middleton MR, Rabinowits G, Spira AI, Yushak M, Mehmi I, Fang F, Chen S, Mani J, Jankovic V, Wang F, Fiaschi N, Brennan L, Paccaly A, Masinde S, Salvati M, Fury MG, Kroog G, Lowy I, Gullo G.   +31 more
europepmc   +1 more source