Results 311 to 320 of about 510,498 (357)
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Immunology Today, 1981
A review focussing on the lessons learned from polyclonal activation of B cells.
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A review focussing on the lessons learned from polyclonal activation of B cells.
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Lymphocyte Subsets and Activation in Prediabetes
Diabetes, 1986Peripheral blood lymphocytes were obtained from 65 individuals: 34 nondiabetic patients with islet cell autoantibodies (ICA) (prediabetic phase), 9 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM), 6 ICA-negative siblings or offsprings of IDDM patients, and 16 ICA-negative controls.
R Pyka +4 more
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Cytotoxic activity of lymphocytes
Cellular Immunology, 1979Abstract Cell-free extracts of human lymphocytes activated by PHA contain a cytotoxin that kills mouse L cells. Such cells elaborate two different kinds of toxins into the culture supernatant fluids, called α- and β-lymphotoxin (-LT), which differ in size, stability, and antigenicity.
Sheng-Chung Lee, Zoltan J. Lucas
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Calcium and T lymphocyte activation
Cell, 1989A prolonged (at least 2-4 hr) elevation of [Ca2+]i accompanies early T cell activation by TCR/CD3-specific ligands. Ca2+ is generally thought to be an essential second messenger for early activation, but the precise molecular events contingent upon the Ca2+ signal remain to be determined.
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Activation signals of T lymphocytes in microgravity
Journal of Biotechnology, 1996Human peripheral blood lymphocytes and monocytes were activated with concanavalin A with or without exogenous recombinant interleukin 1 (IL-1) alone or IL-1 + interleukin 2 (IL-2) under microgravity conditions to test the hypothesis that lack of production of IL-1 by monocytes is the cause of the near total loss of activation observed earlier on ...
PIPPIA P +5 more
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Mechanisms of T lymphocyte activation
Immunology Letters, 1991The proliferation of T lymphocytes in response to an antigenic stimulus requires the successive ligation of a range of T lymphocyte receptors by MHC-presented antigen, molecules expressed on the surfaces of accessory cells and lymphokines. A range of intracellular signalling systems are involved, with the possibility of alternative activation pathways ...
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Ion channels and lymphocyte activation
Immunology Letters, 2004The ion channels expressed by T lymphocytes play key roles in the control of the membrane potential and calcium signaling, thereby affecting signal transduction pathways that lead to the activation of these cells following antigenic stimulation. Disruption of these pathways can attenuate or prevent the response of T-cells to antigenic challenge ...
Panyi, György +2 more
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Lymphocyte Activation in Health and Disease
Critical Reviews in Immunology, 1997Lymphocytes employ a complex assembly of signaling elements that have been organized on a spatiotemporal map to define their role in stimulating both proliferation and apoptosis. The antigen/major histocompatibility complex (MHC) initiates the sequence by organizing the assembly of an active T-cell receptor (TCR) complex responsible for transmitting ...
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Monitoring RhoGTPase Activity in Lymphocytes
2010L-selectin is a cell adhesion molecule (CAM) that is essential for the tethering and subsequent rolling of naïve lymphocytes along the luminal wall of postcapillary venules entering lymph nodes. As with many CAMs, L-selectin has the capacity to transduce intracellular signals in response to ligand binding. This implicates CAMs involved in tethering and
Zarrouk, M, Killock, D, Ivetic, A
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Tempering lymphocyte activation
Science, 2020Immunodeficiency Diagnosis and treatment of inborn errors in immunity remain a challenge. Salzer et al. studied two siblings who were hospitalized for recurrent pediatric infections. Exome sequencing and functional analyses helped to identify homozygous loss-of-function mutations in genes encoding the protein HEM1 in both individuals.
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