Results 341 to 350 of about 4,241,016 (384)

Effects of cadmium on lymphocyte activation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
The effects of cadmium (Cd) on phytohemoagglutinin or phorbol myristate acetate-induced lymphocyte activation were investigated and a dose-dependent inhibition of cell proliferation was found. Kinetic studies revealed that the Cd-sensitive step is an early event of T cell stimulation. Failure of IL2 secretion and reduction of IL2 receptor expression in
Grazia Cifone M, Alesse E, Procopio A, PAOLINI, Rossella, MORRONE, Stefania, Di Eugenio R, Santoni G, SANTONI, Angela   +7 more
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Lipid rafts in lymphocyte activation

Microbes and Infection, 2004
The existence of sphingolipid- and cholesterol-rich membrane microdomains called "lipid rafts", as well as their role in lymphocyte biology, has been widely debated during the last few years. Plasma membrane microdomains seem to be primarily involved in initiation and propagation of the signal transduction cascade associated with lymphocyte activation.
PIZZO, PAOLA, VIOLA A.
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B lymphocyte activation

Immunology Today, 1981
A review focussing on the lessons learned from polyclonal activation of B cells.
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Lymphocyte Subsets and Activation in Prediabetes

Diabetes, 1986
Peripheral blood lymphocytes were obtained from 65 individuals: 34 nondiabetic patients with islet cell autoantibodies (ICA) (prediabetic phase), 9 patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM), 6 ICA-negative siblings or offsprings of IDDM patients, and 16 ICA-negative controls.
R Pyka, N. K. Maclaren, C. L. Hitchcock, William J. Riley, A Alamo   +4 more
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Contingent genetic regulatory events in T lymphocyte activation.

Science, 1989
Interaction of antigen in the proper histocompatibility context with the T lymphocyte antigen receptor leads to an orderly series of events resulting in morphologic change, proliferation, and the acquisition of immunologic function. In most T lymphocytes
G. Crabtree
semanticscholar   +1 more source

Cytotoxic activity of lymphocytes

Cellular Immunology, 1979
Abstract Cell-free extracts of human lymphocytes activated by PHA contain a cytotoxin that kills mouse L cells. Such cells elaborate two different kinds of toxins into the culture supernatant fluids, called α- and β-lymphotoxin (-LT), which differ in size, stability, and antigenicity.
Sheng-Chung Lee, Zoltan J. Lucas
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Calcium and T lymphocyte activation

Cell, 1989
A prolonged (at least 2-4 hr) elevation of [Ca2+]i accompanies early T cell activation by TCR/CD3-specific ligands. Ca2+ is generally thought to be an essential second messenger for early activation, but the precise molecular events contingent upon the Ca2+ signal remain to be determined.
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Activation signals of T lymphocytes in microgravity

Journal of Biotechnology, 1996
Human peripheral blood lymphocytes and monocytes were activated with concanavalin A with or without exogenous recombinant interleukin 1 (IL-1) alone or IL-1 + interleukin 2 (IL-2) under microgravity conditions to test the hypothesis that lack of production of IL-1 by monocytes is the cause of the near total loss of activation observed earlier on ...
PIPPIA P, SCIOLA, Gian Luigi, COGOLI GREUTER M, MELONI M. A, SPANO, Alessandra, COGOLI A.   +5 more
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Mechanisms of T lymphocyte activation

Immunology Letters, 1991
The proliferation of T lymphocytes in response to an antigenic stimulus requires the successive ligation of a range of T lymphocyte receptors by MHC-presented antigen, molecules expressed on the surfaces of accessory cells and lymphokines. A range of intracellular signalling systems are involved, with the possibility of alternative activation pathways ...
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Ion channels and lymphocyte activation

Immunology Letters, 2004
The ion channels expressed by T lymphocytes play key roles in the control of the membrane potential and calcium signaling, thereby affecting signal transduction pathways that lead to the activation of these cells following antigenic stimulation. Disruption of these pathways can attenuate or prevent the response of T-cells to antigenic challenge ...
Panyi, György, Varga, Zoltán, Gáspár, Rezső   +2 more
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