Results 351 to 360 of about 4,241,016 (384)

Lymphocyte Activation in Health and Disease

Critical Reviews in Immunology, 1997
Lymphocytes employ a complex assembly of signaling elements that have been organized on a spatiotemporal map to define their role in stimulating both proliferation and apoptosis. The antigen/major histocompatibility complex (MHC) initiates the sequence by organizing the assembly of an active T-cell receptor (TCR) complex responsible for transmitting ...
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The immunological synapse: a molecular machine controlling T cell activation.

Science, 1999
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an
A. Grakoui, S. Bromley, C. Sumen, M. Davis, A. Shaw, P. Allen, Michael Loran Dustin   +6 more
semanticscholar   +1 more source

CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development.

Annual Review of Immunology, 1994
CD45 is one of the most abundant leukocyte cell surface glycoproteins and is expressed exclusively upon cells of the hematopoietic system. Different isoforms of CD45 are generated by alternative splicing and are expressed in cell type-specific patterns ...
I. Trowbridge, M. Thomas
semanticscholar   +1 more source

Monitoring RhoGTPase Activity in Lymphocytes

2010
L-selectin is a cell adhesion molecule (CAM) that is essential for the tethering and subsequent rolling of naïve lymphocytes along the luminal wall of postcapillary venules entering lymph nodes. As with many CAMs, L-selectin has the capacity to transduce intracellular signals in response to ligand binding. This implicates CAMs involved in tethering and
Zarrouk, M, Killock, D, Ivetic, A
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Tempering lymphocyte activation

Science, 2020
Immunodeficiency Diagnosis and treatment of inborn errors in immunity remain a challenge. Salzer et al. studied two siblings who were hospitalized for recurrent pediatric infections. Exome sequencing and functional analyses helped to identify homozygous loss-of-function mutations in genes encoding the protein HEM1 in both individuals.
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T Lymphocyte Activation in Graves' Disease

Endocrine Research, 1994
We examined the proliferative response of T lymphocytes from thirty-eight patients with Graves' disease (17 untreated thyrotoxic and 30 euthyroid on antithyroid medication) to phytohemagglutinin, anti-CD3 MoAb and phorbol esters, as well as the capacities of these lymphocytes to produce interleukin 2 and the density of interleukin 2 receptors and major
A. Durántez, Mónica Marazuela, Juan A. Vargas, Melchor Alvarez-Mon   +3 more
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PARAMETERS OF LYMPHOCYTE ACTIVATION

1977
Publisher Summary This chapter discusses a few dissociations found among the parameters of activation and present models, which may be useful in understanding the meaning of lymphocyte activation. It also highlights several metabolic processes that have been reported to change following the stimulation of lymphocytes.
Gary R. Klimpel, David O. Lucas
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STUDIES OF LYMPHOCYTE ACTIVATION

1979
Publisher Summary This chapter presents some studies of lymphocyte activation. The results of these studies suggested that exogenous arachidonic acid can stimulate the incorporation of tritiated thymidine into DNA; that inhibitors of arachidonic acid metabolism, particularly those affecting thromboxane synthesis, inhibit the DNA synthetic response to
Charles W. Parker, James P. Kelly
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T-LYMPHOCYTE ACTIVATION AND ALLERGY

The Lancet, 1988
CANONICA, GIORGIO, BAGNASCO, MARCELLO
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Off‐Signals in Lymphocyte Activation

Scandinavian Journal of Immunology, 1976
High‐dose unresponsiveness to concanavalin A affected T and B lymphocytes equally, although only T cells were activated by Con A. Thus, activation and inactivation signals art totally unrelated, the latter also lacking target cell specificity. The off‐signal caused cell death and is probably biologically unimportant.
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